A5074146258- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Traumatic Brain Injury Research
- Advanced Glycation End Products research
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Biochemical Analysis and Sensing Techniques
- Functional Brain Connectivity Studies
- MicroRNA in disease regulation
University of Eastern Finland
2020-2022
Purdue University West Lafayette
2017-2018
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer's disease (AD). Here we report that the internalization of significantly increased isolated from AD mouse brains. We also demonstrate degradation by mice at age 6 months onwards. Furthermore, for first time similar phenomenon between human...
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to remain poorly described. The aim of this study was evaluate mucosa differences between cognitively healthy individuals and disease patients. We report increased amyloid-beta secretion detail cell-type-specific gene expression patterns, unveiling 240...
Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears be important, the specific mechanistic causes of such disorders remain elusive. Here, determine mechanical variables governing tissue eventually cascading into cognitive deficits, we performed a study on mechanics rat under blast conditions. this end, experiments were carried out analyse correlate post-injury distribution...
ABSTRACT Olfactory dysfunction manifests early in several neurodegenerative disorders. Olfaction is orchestrated by olfactory mucosal cells located the upper nasal cavity. However, it unclear how this tissue reflects key features Alzheimer’s disease. Here we report that disease obtained from live individuals secrete toxic amyloid-beta. We detail cell-type-specific gene expression patterns, unveiling 147 differentially expressed disease-associated genes compared to cognitively healthy...
Abstract Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer’s disease (AD). Here we report that the internalization degradation of are significantly increased isolated from aged AD mouse brains. We also demonstrate for first time similar phenomenon between human neurons astrocytes, murine...