A5085739668- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Biochemical Analysis and Sensing Techniques
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Advanced Drug Delivery Systems
- Receptor Mechanisms and Signaling
- Peroxisome Proliferator-Activated Receptors
- Air Quality Monitoring and Forecasting
- Advanced Glycation End Products research
- Neuroscience and Neuropharmacology Research
- Indoor Air Quality and Microbial Exposure
- Long-Term Effects of COVID-19
- Biotin and Related Studies
- Pharmaceutical studies and practices
- Sympathectomy and Hyperhidrosis Treatments
- Adipose Tissue and Metabolism
- Advancements in Transdermal Drug Delivery
- Climate Change Communication and Perception
- biodegradable polymer synthesis and properties
- Energy and Environment Impacts
- Sports injuries and prevention
- Lymphatic System and Diseases
- Neurological Disease Mechanisms and Treatments
University of Eastern Finland
2017-2024
San Francisco State University
2021
University of California, San Francisco
2021
University of Helsinki
2015
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer's disease (AD). Here we report that the internalization of significantly increased isolated from AD mouse brains. We also demonstrate degradation by mice at age 6 months onwards. Furthermore, for first time similar phenomenon between human...
Clozapine (CZP) is an atypical antipsychotic, the most effective for treatment of resistant schizophrenia. With aim overcome limitations current dosage forms (tablets or suspensions) and routes administration (oral intramuscular), this research project proposes nanocarrier systems intranasal (IN) CZP. In particular, have been developed direct nose-to-brain (N2B) route, which allows delivery drug to central nervous system (CNS), bypassing blood-brain barrier (BBB). This study focusses on...
Glucocorticoid receptor (GR) and androgen (AR) are steroid-inducible transcription factors (TFs). The GR the AR central regulators of various metabolic, homeostatic differentiation processes hence important therapeutic targets, especially in inflammation prostate cancer, respectively. Hormone binding to these steroid receptors (SRs) leads DNA activation or repression their target genes with aid interacting proteins, coregulators. However, protein interactomes drug targets have remained...
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to remain poorly described. The aim of this study was evaluate mucosa differences between cognitively healthy individuals and disease patients. We report increased amyloid-beta secretion detail cell-type-specific gene expression patterns, unveiling 240...
The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in last decade. Oxidative stress inflammation are key consequences exposure to PM although little known exact mechanism. association with deteriorating brain health speculated be driven entry via olfactory system. How affect this site remains elusive. In study, we investigated urban size-segregated a novel cellular...
Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bioenergetics demand increases and becomes reliant upon fatty acid oxidation as a source energy. Defective mitochondrial dysfunctions correlate with hippocampal neurodegeneration memory deficits in Alzheimer's disease (AD), but it is unclear whether metabolism can be targeted to prevent or treat disease. Here we show for first time an impairment human astrocytes derived from induced pluripotent stem...
An early symptom of Alzheimer's disease (AD) is an impaired sense smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), performed global RNA sequencing to determine gene expression changes. ONS expressed markers neuroglial differentiation, providing a unique cellular model explore changes AD-associated pathways. Our transcriptomics data revealed differentially genes...
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role AD remains poorly understood, particularly astrocytes, main glial cell type brain. In this study, we investigated alterations ITGB3 gene protein expression during aging different regions of 5xFAD...
Ultrafine particles (UFP) with a diameter of ≤0.1 μm, are contributors to ambient air pollution and derived mainly from traffic emissions, yet their health effects remain poorly characterized. The olfactory mucosa (OM) is located at the rooftop nasal cavity directly exposed both environment brain. Mounting evidence suggests that pollutant affect brain through tract, however, exact cellular mechanisms how OM responds pollutants known. Here we show responses primary human cells altered upon...
Abstract Background The neurological effects of the coronavirus disease 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk Alzheimer's (AD). Neuroinflammation and other AD-associated pathologies are also suggested to increase serious SARS-CoV-2 infection. Anosmia is a common symptom reported in COVID-19 early AD. olfactory mucosa (OM) important for perception smell proposed site viral entry brain. However, little known infection at OM individuals...
Constituents of air pollution, the ultrafine particles (UFP) with a diameter ≤0.1 μm, are considerably related to traffic emissions. Several studies link pollution Alzheimer's disease (AD), yet exact relationship between two remains poorly understood. Mitochondria known targets environmental toxicants, and their dysfunction is associated neurodegenerative diseases. The olfactory mucosa (OM), located at rooftop nasal cavity, directly exposed environment in contact brain. Mounting evidence...
Clozapine (CZP) is the only effective drug in schizophrenia resistant to typical antipsychotics. However, existing dosage forms (oral or orodispersible tablets, suspensions intramuscular injection) show challenging limitations. After oral administration, CZP has low bioavailability due a large first-pass effect, while i.m. route often painful, with patient compliance and requiring specialised personnel. Moreover, very aqueous solubility. This study proposes intranasal as an alternative of...
Respiratory viruses have a significant impact on health, as highlighted by the COVID-19 pandemic. Exposure to air pollution can contribute viral susceptibility and be associated with severe outcomes, suggested recent epidemiological studies. Furthermore, exposure particulate matter (PM), an important constituent of pollution, is linked adverse effects brain, including cognitive decline Alzheimer's disease (AD). The olfactory mucosa (OM), tissue located at rooftop nasal cavity, directly...
Olfactory function, orchestrated by the cells of olfactory mucosa at rooftop nasal cavity, is disturbed early in pathogenesis Alzheimer's disease (AD). Biometals including zinc and calcium are known to be important for sense smell altered brains AD patients. Little about elemental homeostasis patient mucosa. Here we aimed assess whether disease-related alterations biometal observed brain also reflected We applied RNA sequencing discover gene expression changes related metals mucosal...
Abstract An early symptom of Alzheimer’s disease (AD) is an impaired sense smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), performed global RNA sequencing to determine gene expression changes. ONS expressed markers neuroglial differentiation, providing a unique cellular model explore AD-associated pathways. Our transcriptomics data revealed differentially genes...
ABSTRACT Olfactory dysfunction manifests early in several neurodegenerative disorders. Olfaction is orchestrated by olfactory mucosal cells located the upper nasal cavity. However, it unclear how this tissue reflects key features Alzheimer’s disease. Here we report that disease obtained from live individuals secrete toxic amyloid-beta. We detail cell-type-specific gene expression patterns, unveiling 147 differentially expressed disease-associated genes compared to cognitively healthy...
Abstract Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer’s disease (AD). Here we report that the internalization degradation of are significantly increased isolated from aged AD mouse brains. We also demonstrate for first time similar phenomenon between human neurons astrocytes, murine...