A5054962878- Air Quality and Health Impacts
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality Monitoring and Forecasting
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Energy and Environment Impacts
- Indoor Air Quality and Microbial Exposure
- Health, Environment, Cognitive Aging
- Vehicle emissions and performance
- Carcinogens and Genotoxicity Assessment
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Cellular transport and secretion
- Tryptophan and brain disorders
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Barrier Structure and Function Studies
- Lysosomal Storage Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stress Responses and Cortisol
- Noise Effects and Management
University of Eastern Finland
2019-2024
Institute of Medical Biology
2018
Agency for Science, Technology and Research
2018
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer's disease (AD). Here we report that the internalization of significantly increased isolated from AD mouse brains. We also demonstrate degradation by mice at age 6 months onwards. Furthermore, for first time similar phenomenon between human...
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to remain poorly described. The aim of this study was evaluate mucosa differences between cognitively healthy individuals and disease patients. We report increased amyloid-beta secretion detail cell-type-specific gene expression patterns, unveiling 240...
The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in last decade. Oxidative stress inflammation are key consequences exposure to PM although little known exact mechanism. association with deteriorating brain health speculated be driven entry via olfactory system. How affect this site remains elusive. In study, we investigated urban size-segregated a novel cellular...
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role AD remains poorly understood, particularly astrocytes, main glial cell type brain. In this study, we investigated alterations ITGB3 gene protein expression during aging different regions of 5xFAD...
Ultrafine particles (UFP) with a diameter of ≤0.1 μm, are contributors to ambient air pollution and derived mainly from traffic emissions, yet their health effects remain poorly characterized. The olfactory mucosa (OM) is located at the rooftop nasal cavity directly exposed both environment brain. Mounting evidence suggests that pollutant affect brain through tract, however, exact cellular mechanisms how OM responds pollutants known. Here we show responses primary human cells altered upon...
Abstract Background The neurological effects of the coronavirus disease 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk Alzheimer's (AD). Neuroinflammation and other AD-associated pathologies are also suggested to increase serious SARS-CoV-2 infection. Anosmia is a common symptom reported in COVID-19 early AD. olfactory mucosa (OM) important for perception smell proposed site viral entry brain. However, little known infection at OM individuals...
Epidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration. Ultrafine particles (UFPs) are pollutants remain unregulated in ambient by environmental agencies. Due to their small size (<100 nm), UFPs have the most potential cross bodily barriers and thus impact brain. However, little information exists about how affect brain function. Alzheimer's disease (AD) is common form of dementia, which has been linked pollutant exposure, yet limited available on...
Abstract The Finnish-variant late infantile neuronal ceroid lipofuscinosis, also known as CLN5 disease, is caused by mutations in the gene. Cln5 strongly expressed developing brain and expression continues into adulthood. CLN5, a protein of unknown function, implicated neurodevelopment but detailed investigation lacking. Using Cln5−/− embryos various ages cells harvested from brains we investigated hitherto role brain. Loss results differentiation deficits delays interneuron development...
Abstract INTRODUCTION Studies have correlated living close to major roads with Alzheimer's disease (AD) risk. However, the mechanisms responsible for this link remain unclear. METHODS We exposed olfactory mucosa (OM) cells of healthy individuals and AD patients diesel emissions (DE). Cytotoxicity exposure was assessed, mRNA, miRNA expression, DNA methylation analyses were performed. The discovered altered pathways validated using data from human population‐based Rotterdam Study. RESULTS DE...
The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications beyond these organ have become more evident. Traffic-related pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, Alzheimer's disease. exact pollutant compositions exposure scenarios leading to health not known. Although several components may be at play, experimental studies point a key role ultrafine particles...
Neural stem cells (NCSs) are integral to establishing in vitro models and regenerative medicine. To this day, there is an unmet need enrich these from a heterogeneous cell population for clinical applications without irreversible manipulation. We identified method propagate human NCSs via computational analysis of their mechanical signature. In study, we report novel analytical forces three-dimensional cultures. Further, our results revealed that stemness may, part, be mediated by physical...
Adolescence is often a challenging time in which psychiatric issues have strong connection to mental health disorders later life. The early identification of the problems can reduce burden disease. To date, effective adolescents at risk developing remains understudied. Altogether, interaction between circulating cell-free mtDNA (ccf-mtDNA) and inflammatory cytokines insufficiently understood regarding experienced difficulties. Our study selected participants based on Strength Difficulty...
ABSTRACT Olfactory dysfunction manifests early in several neurodegenerative disorders. Olfaction is orchestrated by olfactory mucosal cells located the upper nasal cavity. However, it unclear how this tissue reflects key features Alzheimer’s disease. Here we report that disease obtained from live individuals secrete toxic amyloid-beta. We detail cell-type-specific gene expression patterns, unveiling 147 differentially expressed disease-associated genes compared to cognitively healthy...
Abstract Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria a process called transmitophagy. Mitophagy is widely reported to be impaired neurodegeneration but it unknown whether how transmitophagy altered Alzheimer’s disease (AD). Here we report that the internalization degradation of are significantly increased isolated from aged AD mouse brains. We also demonstrate for first time similar phenomenon between human neurons astrocytes, murine...
ABSTRACT Epidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration. Ultrafine particles (UFPs) are pollutants remain unregulated in ambient by environmental agencies. Due to their small size (<100nm), UFPs have the most potential cross bodily barriers and thus impact brain. However, little information exists about how affect brain function. Alzheimer’s disease (AD) is common form of dementia, which has been linked pollutant exposure, yet limited available...