A5040146281- Air Quality and Health Impacts
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Vehicle emissions and performance
- Air Quality Monitoring and Forecasting
- Atmospheric chemistry and aerosols
- Catalytic Processes in Materials Science
- Noise Effects and Management
- Thermochemical Biomass Conversion Processes
- Advanced biosensing and bioanalysis techniques
- Indoor Air Quality and Microbial Exposure
- Olfactory and Sensory Function Studies
- Municipal Solid Waste Management
- Forest Biomass Utilization and Management
- bioluminescence and chemiluminescence research
- Advanced Combustion Engine Technologies
- Nanoplatforms for cancer theranostics
University of Eastern Finland
2013-2021
Ambient inhalable particulate matter (PM) is a serious health concern worldwide, but especially so in China where high PM concentrations affect huge populations. Atmospheric processes and emission sources cause spatial temporal variations concentration chemical composition, their influence on the toxicological characteristics of are still inadequately understood. In this study, we report an extensive characterization size-segregated urban air collected August October 2013 from Nanjing,...
Abstract Background Wood combustion emissions have been studied previously either by in vitro or vivo models using collected particles, yet most studies neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity aerosols can be gained with parallel direct exposure methods. Moreover, modern techniques such as air-liquid interface (ALI) exposures enable better assessment applied than, for example, previous state-of-the-art submerged cell techniques. Methods We...
The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in last decade. Oxidative stress inflammation are key consequences exposure to PM although little known exact mechanism. association with deteriorating brain health speculated be driven entry via olfactory system. How affect this site remains elusive. In study, we investigated urban size-segregated a novel cellular...
In vitro studies with monocultures of human alveolar cells shed deeper knowledge on the cellular mechanisms by which particulate matter (PM) causes toxicity, but cannot account for mitigating or aggravating effects cell-cell interactions PM toxicity.
Solid fuel usage in residential heating and cooking is one of the largest sources ambient indoor air particulate matter, which causes adverse effects on health millions peoples worldwide. Emissions from solid combustion, such as biomass or coal, are detrimental to health, but toxicological responses largely unknown. In present study, we compared regarding cytotoxicity, inflammation genotoxicity spruce (SPR) brown coal briquette (BCB) combustion aerosols human alveolar epithelial cells (A549)...
Abstract Background Studies conducted in farm environments suggest that diverse microbial exposure promotes children's lung health. The underlying mechanisms are unclear, and the development of asthma‐preventive strategies has been delayed. More comprehensive investigation environment‐induced immunoregulation is required for better understanding asthma pathogenesis prevention. Exposure to air pollution, including particulate matter ( PM ), a risk factor asthma, thus providing an excellent...
The health risks of air pollutants and ambient particulate matter (PM) are widely known. PM composition toxicity have shown substantial spatiotemporal variability. Yet, the connections between toxicological effects vaguely understood. This is a crucial gap in knowledge that needs to be addressed order establish quality guidelines limit values consider chemical instead current assumption equal per inhaled dose. Here, we demonstrate further evidence for varying urban at mass concentrations,...
Abstract Background Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although new passenger car regulations have been very effective in reducing particulate matter (PM) emissions, aged fleet some EU countries remains substantial source of PM emissions. Moreover, toxicity emissions multiple types bio-based fuels remain uncertain different driving conditions such as...
In this paper, novel firefly luciferase-specific inhibitor compounds (FLICs) are evaluated as potential tools for cellular trafficking of transporter conjugates. As a proof-of-concept, we designed FLICs that were suitable solid phase peptide synthesis and could be covalently conjugated to peptides via an amide bond. The spacer between was optimized gain efficient inhibition recombinant luciferase (FLuc) without compromising the activity model peptides. hypothesis using studies ensured with...