A5054347082- Air Quality and Health Impacts
- Energy and Environment Impacts
- Vehicle emissions and performance
- Climate Change and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Field-Flow Fractionation Techniques
- Advanced Combustion Engine Technologies
- Indoor Air Quality and Microbial Exposure
- Particle Dynamics in Fluid Flows
- Atmospheric chemistry and aerosols
- Air Quality Monitoring and Forecasting
University of Eastern Finland
2018-2024
University of Oulu
2015
The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in humans: TETs 1-3. These convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) DNA, high 5-hmC levels associated with active transcription. importance balance these modified cytosines is emphasized by fact that TET2 mutated several human cancers, including myeloid malignancies such as acute leukemia (AML). We characterize here kinetic inhibitory properties Tets show Km value 1...
Abstract Background Wood combustion emissions have been studied previously either by in vitro or vivo models using collected particles, yet most studies neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity aerosols can be gained with parallel direct exposure methods. Moreover, modern techniques such as air-liquid interface (ALI) exposures enable better assessment applied than, for example, previous state-of-the-art submerged cell techniques. Methods We...
Solid fuel usage in residential heating and cooking is one of the largest sources ambient indoor air particulate matter, which causes adverse effects on health millions peoples worldwide. Emissions from solid combustion, such as biomass or coal, are detrimental to health, but toxicological responses largely unknown. In present study, we compared regarding cytotoxicity, inflammation genotoxicity spruce (SPR) brown coal briquette (BCB) combustion aerosols human alveolar epithelial cells (A549)...
The study evaluates the impact of after-treatment systems, aromatic fuel content, and cold operating temperature on exhaust emission toxicity from vehicles complying with Euro 6d regulation.
The health risks of air pollutants and ambient particulate matter (PM) are widely known. PM composition toxicity have shown substantial spatiotemporal variability. Yet, the connections between toxicological effects vaguely understood. This is a crucial gap in knowledge that needs to be addressed order establish quality guidelines limit values consider chemical instead current assumption equal per inhaled dose. Here, we demonstrate further evidence for varying urban at mass concentrations,...
Abstract Background Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although new passenger car regulations have been very effective in reducing particulate matter (PM) emissions, aged fleet some EU countries remains substantial source of PM emissions. Moreover, toxicity emissions multiple types bio-based fuels remain uncertain different driving conditions such as...
In vitro, direct aerosol nanoparticle exposure of cells cultured at the air-liquid interface (ALI) has shown great potential over conventional submerged cell methods due to relevancy and more accurate dose determination. Here, we present a design an ALI device, thermocollector, which applies thermophoresis deposit particles onto cells. Computational numerical simulations were used estimate deposition flux how it depended on particle properties. The was approximately 250 particles/m2s for...