A5100336924- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
- Dermatology and Skin Diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Noise Effects and Management
- Peripheral Neuropathies and Disorders
- Climate Change and Health Impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parasites and Host Interactions
- Child Nutrition and Water Access
- SARS-CoV-2 and COVID-19 Research
- Autoimmune Neurological Disorders and Treatments
- Herbal Medicine Research Studies
- Body Composition Measurement Techniques
Guangzhou Medical University
2015-2024
First Affiliated Hospital of Guangzhou Medical University
2015-2024
Wuzhou Red Cross Hospital
2024
Guangxi Medical University
2020-2024
Tianjin Medical University
2024
Tianjin Medical University Eye Hospital
2024
State Key Laboratory of Respiratory Disease
2015-2024
National Natural Science Foundation of China
2024
Inner Mongolia Medical University
2024
Xiangya Hospital Central South University
2024
Crucial roles of hematologic and immunologic responses in progression coronavirus disease 2019 (COVID-19) remain largely unclear.We sought to address the dynamic changes biomarkers their associations with severity outcomes COVID-19.A retrospective study including 548 patients COVID-19 clarified outcome (discharged or deceased) from a national cohort China was performed. Cross-sectional longitudinal variations were compared different analyzed.On admission, counts lymphocytes, T-cell subsets,...
To assess olipudase alfa enzyme replacement therapy for non-central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in children.
Non-cystic fibrosis bronchiectasis is a chronic respiratory disease characterized by bronchial dilation. However, the significance of elevated eosinophil counts in acute exacerbations remains unclear.
The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims promote the effect SIT rhinitis (AR) by co-administration with Clostridium butyricum (Cb). In this study, patients AR sensitized mite allergens were enrolled and treated or/and Cb. was evaluated total nasal symptom scores (NSS), medication scores, serum IgE levels T helper (Th)2 cytokine levels. improvement regulation in assessed...
BackgroundAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune nervous system disease that has become increasingly recognized. This retrospective study aimed to analyze the relations between clinical manifestations and blood brain barrier (BBB) integrity in anti-NMDAR patients.MethodsAnti-NMDAR patients were admitted First Affiliated Hospital of Guangxi Medical University from April 2014 2020. Patients grouped by normal BBB damaged groups according cerebrospinal...
Omalizumab is the preferred add-on therapy for patients with moderate-to-severe persistent allergic asthma and has demonstrated efficacy safety in various ethnicities. This study evaluated of omalizumab Chinese asthma.This randomized, double-blind, parallel-group, placebo-controlled, phase III assessed lung function, quality life, control, after 24-week (18-75 years age).A total 616 were randomized (1:1) to or placebo. The primary endpoint, least squares mean treatment difference (LSM-TD)...
Abstract Allergen-specific immunotherapy for house dust mite allergy is effective, but there are no validated biomarkers reflecting or predicting the clinical efficacy. We aimed to investigate relationship between outcomes and functional responses of allergen-specific IgG4 (sIgG4) specific IgE (sIgE) during Dermatophagoides pteronyssinus s.c. allergen (SCIT) in allergic rhinitis and/or asthma patients. Combined symptom medication scores (SMS), D. pteronyssinus–sIgG4 levels,...
Background: Little is known about asthma control and perception of among asthmatic patients on a national scale in China due to the difficulty conducting survey large, vastly distributed population country. We know that medical insurance system may not evenly cover all socioeconomic status varies greatly across cities. Objective: This study marks first conducted was aimed at obtaining baseline information patients’ perceptions providing point reference for future studies. Methods:...
The prevalence of allergic asthma and incidences helminth infections in humans are inversely correlated. Although experimental studies have established the causal relation between parasite infection asthma, mechanism parasite-associated immunomodulation is not fully elucidated. Using a murine model nematode Heligmosomoides polygyrus, we investigated roles regulatory B cells (Breg ) T (Treg mediation protection against by parasite. H. polygyrus significantly suppressed ovalbumin (OVA)-induced...
Background So far, in China, there has been no effective or easy procedure to define the control of asthma. This study assesses validity Asthma Control Test Chinese patients. Methods Three questionnaires (Asthma Test, Questionnaire and 30 second asthma test) were administered 305 patients from 10 teaching hospitals across China. Spirometry was also used. specialists rated according patients' symptoms, medications forced expiratory volume first second. The divided into noncontrolled group...
Abstract Background Asthma is one of the most common chronic diseases in childhood, and prevalence has been increasing over past few decades. One consistent epidemiological findings that children living a farming or rural environment are protected from development asthma allergies, but protective factors China not clear. Methods A community‐based, cross‐sectional study was performed total 17,587 aged 5–8 years, 3435 Hong Kong (urban) 14,152 Conghua (rural county southern China). allergic...
Abstract Background It is now recognized that asthma can present in different forms. Typically, with symptoms of wheeze, breathlessness and cough. Atypical forms such as cough variant (CVA) or chest tightness (CTVA) do not wheeze. We hypothesize these may have distinctive cellular molecular features. Methods 30 patients typical classical (CA), 27 CVA, CTVA, healthy control adults were enrolled this prospective study. measured serum IgE, lung function, sputum eosinophils, nitric oxide exhaled...