A5050689385- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Gut microbiota and health
- Noise Effects and Management
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Occupational exposure and asthma
- Gestational Diabetes Research and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, psychology, and well-being
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Human-Animal Interaction Studies
- Pressure Ulcer Prevention and Management
- T-cell and B-cell Immunology
- Toxic Organic Pollutants Impact
- Mobile Health and mHealth Applications
- Atmospheric chemistry and aerosols
Finnish Institute for Health and Welfare
2016-2025
Tampere University
2023
Université de franche-comté
2019
Centre National de la Recherche Scientifique
2019
University of Helsinki
2019
Brigham and Women's Hospital
2019
Harvard University
2019
National Institutes of Health
2013
University of Eastern Finland
2009
Western lifestyle is associated with high prevalence of allergy, asthma and other chronic inflammatory disorders. To explain this association, we tested the 'biodiversity hypothesis', which posits that reduced contact children environmental biodiversity, including microbiota in natural habitats, has adverse consequences on assembly human commensal its contribution to immune tolerance.We analysed four study cohorts from Finland Estonia (n = 1044) comprising adolescents aged 0.5-20 years. The...
Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, specific description of subtypes atopic depending on the timing onset and progression childhood lacking.To identify different phenotypes using definition based symptoms before age 6 years to determine whether some are more at risk for developing other allergic diseases.The Protection Against Allergy Study Rural Environments (PASTURE) European birth cohort where...
Clinical and epidemiologic approaches have identified two distinct sets of classifications for asthma wheeze phenotypes.To compare phenotype definitions by latent class analysis (LCA) with clinical phenotypes based on patient histories, diagnostic work-up, treatment responses. To relate to genetic environmental determinants as well treatment-related parameters.LCA was performed in an international multicenter birth cohort yearly questions about current until age 6 years. Associations classes...
Abstract Background Genetic susceptibility and environmental influences are important contributors to the development of asthma atopic diseases. Epigenetic mechanisms may facilitate gene by environment interactions in these Methods We studied rural birth cohort PASTURE (Protection against allergy: study environments) investigate (a) whether epigenetic patterns candidate genes influenced farm exposure general, (b) change over first years life, (c) changes contribute asthma. DNA was extracted...
Rationale: Growing up on a farm protects from childhood asthma and early wheeze. Virus-triggered wheeze in infancy predicts individuals with genetic risk associated chromosome 17q21.Objectives: To test environmental determinants of infections the first year life, potential modifications these associations by 17q21, implications for different trajectories wheeze.Methods: We followed 983 children rural areas Europe birth until age 6 years. Symptoms wheeze, rhinitis, fever, exposures were...
We analysed floor dust samples from 65 children's bedrooms in Finland collected 2014/2015 for 62 different per- and polyfluoroalkyl substances (PFASs) with a simple highly efficient method. Validation results the analysis of standard reference material (SRM) 2585 were good agreement literature data, while 24 PFASs quantified first time. In bedrooms, five perfluoroalkyl carboxylic acids (PFCAs) perfluorooctane sulfonic acid (PFOS) detected more than half highest median concentration 5.26 ng/g...
The contamination levels and patterns of perfluoroalkyl acids (PFAAs) their precursors in indoor air children's bedrooms Finland, Northern Europe, were investigated. Our study is among the most comprehensive monitoring studies (n = 57) to our knowledge first one analyse for PFASs (17 PFAAs 9 precursors, including two acrylates, 6:2 FTAC FTMAC). frequently detected compound was 8:2 fluorotelomer alcohol (8:2 FTOH) with highest median concentration (3570 pg/m3). FTOH concentrations generally...
OBJECTIVES: Most previous studies on the association between moisture or mold problems in home and respiratory symptoms children were cross-sectional based self-reported exposure. The aim of this study was to evaluate impact objectively observed damage visible homes early-life morbidity atopic sensitization a birth cohort. METHODS: Building inspection performed by building engineers 396 children, followed up with questionnaires from age 18 months. Specific immunoglobulin E levels measured at...
BACKGROUND: Excess moisture and visible mold are associated with increased risk of asthma. Only a few studies have performed detailed home visits to characterize the extent location damage growth. METHODS: Structured inspections were in birth cohort study when children 5 months old (on average). Children (N = 398) followed up age 6 years. Specific immunoglobulin E concentrations determined at RESULTS: Moisture an early child’s main living areas (but not bathrooms or other interior spaces)...
Background Early-life exposure to environmental microbial agents may be associated with the development of allergies. The aim study was identify better ways characterize as a predictor respiratory symptoms and Methods A birth cohort 410 children followed up until 6 years age. Bacterial endotoxin, 3-hydroxy fatty acids, N-acetyl-muramic acid, fungal extracellular polysaccharides (EPS) from Penicillium Aspergillus spp., β-D-glucan, ergosterol, bacterial or quantitative polymerase chain...
Summary Background Early‐life exposure to environmental microbial agents may be associated with development of wheezing and allergic diseases. Objective To assess the association in rural homes risk asthma, wheezing, atopic dermatitis sensitization. Methods Birth cohorts children ( n = 1133), half from farmer families, were followed up birth 2 years age by questionnaires five European centres. Endotoxin extracellular polysaccharides EPS ) Penicillium Aspergillus spp. determined living room...
The limited understanding of microbial characteristics in moisture-damaged buildings impedes efforts to clarify which adverse health effects the occupants are associated with damage and develop effective building intervention strategies. objectives this current study were (i) characterize fungal bacterial microbiota house dust severely residences, (ii) identify taxa moisture renovations, (iii) test whether associations between identified replicable another cohort homes. We applied 16S rRNA...
Microbial exposures in early childhood direct the development of immune system and their diversity may influence risk allergy development. We aimed to determine whether indoor microbial at early-life is associated with allergic rhinitis inhalant atopy.The study population included children within two birth cohorts: Finnish rural-suburban LUKAS (N = 312), German urban LISA from Munich Leipzig centers 248). The microbiota (Chao1 richness Shannon entropy) was characterized floor dust samples...