A5013891093- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Pediatric health and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Neonatal Respiratory Health Research
- Indoor Air Quality and Microbial Exposure
- IL-33, ST2, and ILC Pathways
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Diet and metabolism studies
- Gut microbiota and health
- Gestational Diabetes Research and Management
- Eosinophilic Esophagitis
- Metabolomics and Mass Spectrometry Studies
- Occupational exposure and asthma
- Pregnancy and preeclampsia studies
- Climate Change and Health Impacts
- Genetic Associations and Epidemiology
- Noise Effects and Management
- Helicobacter pylori-related gastroenterology studies
- Respiratory and Cough-Related Research
- Health, Environment, Cognitive Aging
Harvard Pilgrim Health Care
2016-2025
Harvard University
2016-2025
Brigham and Women's Hospital
2010-2023
Misgav Ladach
2022
Universidad de Salamanca
2022
Precision for Medicine (United States)
2022
British School at Rome
2013
AO Foundation
2013
Menlo School
2013
Uppsala University
2013
Alterations in the intestinal microbiome are prospectively associated with development of asthma; less is known regarding role alterations food allergy development.Intestinal samples were collected at age 3-6 months children participating follow-up phase an interventional trial high-dose vitamin D given during pregnancy. At 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food defined as caretaker report healthcare provider-diagnosed above prior 3 evidence IgE...
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect swabs from the anterior nares 547 children (mean-age 12.9 y), measure DNA methylation (DNAm) with Infinium MethylationEPIC BeadChip. We perform Epigenome-Wide Association analyses (EWAS) current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) lung function. find multiple differentially methylated CpGs (FDR < 0.05) Regions (DMRs; ≥ 5-CpGs...
SummaryBackgroundAlthough proteins derived from cats are an important contributor to indoor allergen exposure in relation asthma, it has been known for at least twenty years that some children who live a house with cat can become clinically tolerant these animals. In 2001, we reported exposed high levels of allergens made IgG4 antibodies the Fel d 1, and coined term "a modified Th2 response". However, this phenomenon is still poorly understood.MethodsWe studied serum among 616 individuals...
<h3>Importance</h3> In animal models, the early life gut microbiome influences later neurodevelopment. Corresponding data in human populations are lacking. <h3>Objective</h3> To study associations between infants and development at preschool age measured by Ages Stages Questionnaire, third edition (ASQ-3). <h3>Design, Setting, Participants</h3> This ancillary cohort of Vitamin D Antenatal Asthma Reduction Trial (VDAART) used from 715 participants who had assessed 3 years ASQ-3, which...
Environmental microbes have been associated with both protective and adverse health effects in children adults. Epidemiological studies often rely on broad biomarkers of microbial exposure (i.e. endotoxin, 1 → 3-beta-d-glucan), but fail to identify the taxonomic composition community. Our aim was characterize bacterial fungal microbiome different types environmental samples collected human effects. We determined communities present home, school outdoor air by amplifying sequencing regions...
Abstract Long-term exposure to ambient air pollution has been associated with epigenetic age acceleration (EAA) in adults, but its impact on children remains less understood. This study analyzed data from 457 (mean age: 7.9 years) the Project Viva cohort (2007-2010, eastern Massachusetts, USA). We calculated EAA leukocytes: Horvath’s Epigenetic Age Acceleration (HorvathEAA), Intrinsic (IEAA), and Skin Blood (Skin&BloodEAA). applied generalized additive models evaluate associations of...
Summary Background Experimental animal data on the gram‐negative bacterial (GNB) biomarker endotoxin suggest that persistence, dose, and timing of exposure are likely to influence its effects allergy wheeze. In epidemiologic studies, may be a sentinel marker for microbial milieu, including gram‐positive bacteria (GPB) as well GNB, asthma through components (pathogen‐associated molecular patterns) signal innate Toll‐like receptor pathways. Objective To determine current GNB GPB exposures...
Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in world. Metabolomic profiling of asthmatics taking presents new and promising resource identifying molecular determinants asthma control. The objective is to identify novel genetic biochemical predictors control using an integrative "omics" approach. We generated lipidomic data by liquid chromatography tandem mass spectrometry (LC-MS), - plasma samples...
Sequencing of the 16S rRNA gene allows comprehensive assessment bacterial community composition from human body sites. Previously published and publicly accessible data on 58 preterm infants in Neonatal Intensive Care Unit who underwent frequent stool collection was used. We constructed Dynamic Bayesian Networks analyzed predictive performance network characteristics. a DBN model infant gut microbial ecosystem, which explicitly captured specific relationships general trends data: increasing...
BackgroundMeasurement of fungal and bacterial biomarkers can be costly, but it is not clear whether home characteristics used as a proxy these markers, particularly if the purpose to differentiate specific classes biologic exposures that have similar sources may different effects on allergic disease risk.ObjectiveWe evaluated predictors multiple microbial biomarkers, with focus common unique determinants attention extent their explanatory ability.MethodsIn 376 Boston-area homes enrolled in...
Objectives To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear (LINE-1) lung function. Design Cohort study. Setting Outpatient Veterans Administration facilities in greater Boston, Massachusetts, USA. Participants Individuals from Normative Aging Study, a longitudinal study aging men, evaluated 1999 2007. The majority (97%) were white. Primary secondary outcome measures predictor was methylation, assessed using PCR-pyrosequencing...
Summary Background Infancy is a developmental stage with heightened susceptibility to environmental influences on the risk of chronic childhood disease. Few birth cohort studies have detailed measures fungal diversity data in infants' bedrooms, limiting potential measure long‐term associations these complex exposures development asthma or allergy. Objective We evaluated relation home levels infancy repeated wheeze and rhinitis by age 13, sensitization 12 years. Methods In Epidemiology Home...