A5100841007- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Nanocluster Synthesis and Applications
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Sinusitis and nasal conditions
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cleft Lip and Palate Research
- BRCA gene mutations in cancer
- CAR-T cell therapy research
- Digestive system and related health
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
German Cancer Research Center
2018-2025
Heidelberg University
2018-2025
Shanghai Jiao Tong University
2023-2025
Renji Hospital
2023-2025
Shanghai Cancer Institute
2023-2025
Immune Regulation (United Kingdom)
2023-2025
Shenzhen University
2009-2024
Shenzhen Second People's Hospital
2008-2024
Shenzhen University Health Science Center
2018-2024
State Key Laboratory of Oncogene and Related Genes
2023
Photoacoustic imaging (PAI) is an attractive modality, which promising for clinical cancer diagnosis due to its advantages on deep tissue penetration and fine spatial resolution. However, few tumor catalytic/responsive PAI strategies are developed. Here, we design exosome-like nanozyme vesicle in vivo H2O2-responsive of nasopharyngeal carcinoma (NPC). The intrinsic peroxidase-like activity graphene quantum dot (GQDzyme) effectively converts the 2,2′-azino-bis...
The dysregulated expression of immune checkpoint molecules enables cancer cells to evade destruction. While blockade inhibitory checkpoints like PD-L1 forms the basis current immunotherapies, a deficiency in costimulatory signals can render these therapies futile. CD58, ligand, plays crucial role antitumor responses, but mechanisms controlling its remain unclear. Using two systematic approaches, we reveal that CMTM6 positively regulates CD58 expression. Notably, interacts with both and...
The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims promote the effect SIT rhinitis (AR) by co-administration with Clostridium butyricum (Cb). In this study, patients AR sensitized mite allergens were enrolled and treated or/and Cb. was evaluated total nasal symptom scores (NSS), medication scores, serum IgE levels T helper (Th)2 cytokine levels. improvement regulation in assessed...
Non-medullary thyroid cancer (NMTC) is a common endocrine malignancy with genetic basis that has yet to be unequivocally established. In recent whole-genome sequencing study of five families occurrence NMTCs, we shortlisted promising variants the help bioinformatics tools. Here, report in silico analyses and vitro experiments on novel germline variant (p.V29L) highly conserved oligonucleotide/oligosaccharide binding domain Protection Telomeres 1 (POT1) gene one families. The results showed...
Familial colorectal cancer (CRC) is only partially explained by known germline predisposing genes. We performed whole-genome sequencing in 15 Polish families of many affected individuals, without mutations CRC focused on loss-of-function variants and functionally characterized them. identified a frameshift variant the CYBA gene (c.246delC) one family splice site TRPM4 (c.25-1 G > T) another family. While both were absent or extremely rare databases, we four additional familial cases two...
Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role GPX4 in regulating ferroptosis, our understanding protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as regulator protein. Inhibition expression enhances ubiquitination-mediated degradation up-regulating E3 ubiquitin ligase RC3H1. Using both rescue assays and functional...
Cancer cells, immune and stromal cells within the tumor microenvironment (TME) collaboratively influence disease progression therapeutic responses. The nutrient-limited conditions of TME, particularly scarcity glucose, amino acids, lipids, challenge cancer cell survival. However, metabolic constraints faced by in comparison to how these limitations affect outcomes, remain poorly understood. Here, we introduce Dual Ribosome Profiling (DualRP), a method that allows for simultaneous analysis...
Thyroid cancer (TC) is the most common endocrine malignancy, with 90%-95% of cases representing non-medullary thyroid (NMTC). Familial account only for a few all and underlying genetic causes are still poorly understood. We whole-genome sequenced affected unaffected members an Italian NMTC family applied our in-house developed Cancer Variant Prioritization Pipeline (FCVPPv2) which prioritized 12 coding variants. refined this selection using VarSome American College Medical Genetics Genomics...
Background Th2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation its mechanism necessary. The cells patients with diseases have been found to abnormal epigenetic status. This research intends examine role methyltransferase-like 5 (Mettl5) in regulating homeostasis CD4 + T cells. Methods An AA mouse model was established dust mite extracts as a specific antigen. marks Gata3 gene were evaluated using chromatin...
Nanodynamic therapy (NDT) based on reactive oxygen species (ROS) production has been envisioned as an effective cancer treatment. However, the efficacy is limited by hypoxia, insufficient hydrogen peroxide conversion, and high glutathione (GSH) levels in tumor microenvironment (TME). To solve these issues, we proposed designed a biocompatible, resistant Cu-modified Ti
There are controversies on management of carotid artery invasion in advanced head and neck cancer. En bloc resection has been considered a curative modality. In this study, we evaluated the feasibility using expanded polytetrafluoroethylene (ePTFE) reconstructing common patients with requiring resection.A retrospective study including 13 managed from 2002 to 2005. All underwent en tumor internal then reconstructed ePTFE.All had together reconstruction ePTFE. Some required wound coverage...
Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively) poorly understood. This study was conducted to assess importance transcription factor FoxA2 investigate targeting as a potential therapeutic strategy for mucus hypersecretion patients. We enrolled 15 CRSwNP patients, CRSsNP 10 normal controls this study. The expression levels...
Background Cysteinyl leukotriene (LT) has been proposed in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). This study sought to examine expression LT receptor (LTR) CRSwNP patients and evaluate potential role LTR antagonist (LTRA) management eosinophilic (ECRS) patients. Methods Nasal uncinate process tissues were collected from 18 ECRS patients, 13 non‐eosinophilic (non‐ECRS) 16 control subjects. The messenger RNA (mRNA) protein (cysteinyl 1 [CysLT1R] cysteinyl 2...
Binding of transcription factors to mutated DNA sequences is a likely regulator cancer progression. Noncoding regulatory mutations such as those on the core promoter gene encoding human telomerase reverse transcriptase have been shown affect expression in cancer. Using protein microarray 667 factor DNA-binding domains and subsequent functional assays, we looked for that preferentially bind mutant hTERT characterized their downstream effects. One them, friend leukemia integration 1 (FLI1),...
: Early and aggressive metastasis is a major feature of pancreatic ductal adenocarcinoma. Understanding the processes underlying crucial for making difference to disease outcome. Towards these ends, we looked in comprehensive manner genes that are metastasis-specific.
Melanoma, the most prevalent form of skin cancer, is primarily treated with surgical intervention. However, complete tumor cell removal challenging, and wounds are prone to infection, complicating treatment increasing costs. The successful melanoma generally requires multifunctional agents that coordinated in therapy wound healing. In this study, we developed platinum (Pt)- selenium (Se)-based nanozymes, Pt-Se@Chitosan (PS@CS), which exhibit synergistic antitumor bactericidal efficacy...
Abstract Using Chlamydia trachomatis (Ct) as a complex model organism, we describe method to generate bacterial whole-proteome microarrays using cell-free, on-chip protein expression. Expression constructs were generated by two successive PCRs directly from genomic DNA. Bacterial proteins expressed on display antigenic epitopes, thereby providing an efficient for immunoprofiling of patients and allowing de novo identification disease-related serum antibodies. Through comparison antibody...
The co-polymer of transferrin-conjugated chitosan-<italic>graft</italic>-poly(<sc>l</sc>-lysine) dendrons was used to deliver the MMP-9 shRNA plasmid effectively for nasopharyngeal carcinoma gene therapy.
Familial inheritance in non-medullary thyroid cancer (NMTC) is an area that has yet to be adequately explored. Despite evidence suggesting strong familial clustering of non-syndromic NMTC, known variants still account for a very small percentage the genetic burden. In recent whole genome sequencing (WGS) study five families with several NMTCs, we shortlisted promising help our in-house developed Cancer Variant Prioritization Pipeline (FCVPPv2). Here, report potentially disease-causing...