A5025940380- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Hypothalamic control of reproductive hormones
- Sexual function and dysfunction studies
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Pregnancy-related medical research
- Creativity in Education and Neuroscience
- Regulation of Appetite and Obesity
- Child and Adolescent Psychosocial and Emotional Development
- Urinary Bladder and Prostate Research
- Ovarian function and disorders
Indiana University – Purdue University Indianapolis
2014-2025
Indiana University School of Medicine
2012-2024
University School
2005-2020
Indiana University
2005-2020
Neurosciences Institute
2012-2018
University of California, Santa Barbara
2009
Maj Institute of Pharmacology
2009
Polish Academy of Sciences
2009
University of Cincinnati
2003-2004
University of Cincinnati Medical Center
2002-2003
We tested the significance of a population lumbar spinothalamic cells for male sexual behavior in rats. These are positioned to relay ejaculation-related signals from reproductive organs brain, and they express neurokinin-1 receptors. Ablation these neurons by selective toxin SSP-saporin resulted complete disruption ejaculatory behavior. In contrast, other components remained intact. results suggest that this plays pivotal role generation may be part spinal ejaculation generator.
The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and trauma-related disorders such as panic disorder post-traumatic stress disorder, respectively. However, neural mechanisms how serotonergic neurotransmission regulates innate fear brain networks are poorly understood. Our earlier studies have identified that orexin (OX)/glutamate neurons within perifornical hypothalamic area (PFA) play a critical role adaptive pathological fear. While site-specific...
Homer proteins are constituents of scaffolding complexes that regulate the trafficking and function central Group1 metabotropic glutamate receptors (mGluRs) N-methyl-d-aspartate (NMDA) receptors. Research supports involvement these in ethanol-induced neuroplasticity mouse. In this study, we examined effects short versus long-term withdrawal from chronic ethanol consumption on receptor protein expression within striatal amygdala subregions selectively bred, alcohol-preferring P rats.For 6...
The precise pathways that convey copulation-related information to forebrain regions activated during male and female sexual behavior are poorly understood. Previous work from our laboratory others has demonstrated the existence of a spinothalamic pathway is candidate relay these areas. This originates population neurons in lumbar spinal cord containing several neuropeptides including galanin, located laminas 7 10 segments 3 4. To investigate involvement conveying information, we tested...
Panic patients are vulnerable to induction of panic attacks by sub-threshold interoceptive stimuli such as intravenous (i.v.) sodium lactate infusions. Facilitation serotonergic signaling with selective serotonin reuptake inhibitors can suppress anxiety and panic-like responses, but the mechanisms involved not clearly defined. We investigated effects i.v. 0.5 M or saline, in control panic-prone rats on c-Fos expression neurons within subdivisions midbrain/pontine raphe nuclei. Rats were...
The development of successful pharmacotherapeutics for the treatment alcoholism is predicated upon understanding biological action alcohol. A limitation alcohol research field has been examining effects only and ignoring multiple active metabolites concept that a "pro-drug" not new. Alcohol readily metabolized to acetaldehyde within brain. Acetaldehyde highly reactive compound forms number condensation products, including salsolinol iso-salsolinol (acetaldehyde dopamine). Recent experiments...
Abstract The rate of codependency for alcohol and nicotine is extremely high. Numerous studies have indicated that there a common genetic association alcoholism dependency. current experiments examined whether selective breeding high preference in rats may be associated with increased sensitivity the posterior ventral tegmental area ( pVTA ) to reinforcing properties nicotine. In addition, can directly bind serotonin‐3 (5‐ HT 3 receptor, which has been shown mediate other drugs abuse within...