A5003938450- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Childhood Cancer Survivors' Quality of Life
- Neuropeptides and Animal Physiology
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Cancer therapeutics and mechanisms
- Health and Medical Research Impacts
- Memory and Neural Mechanisms
- Biomedical and Engineering Education
- Family Support in Illness
- Cancer-related cognitive impairment studies
- Multiple Myeloma Research and Treatments
- Health Sciences Research and Education
- Birth, Development, and Health
- Pain Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Neuroblastoma Research and Treatments
- Chemical synthesis and alkaloids
- Lymphatic System and Diseases
- Patient-Provider Communication in Healthcare
University of Indianapolis
2024
Indiana University – Purdue University Indianapolis
2012-2024
Indiana University
2000-2024
Indiana University School of Medicine
2012-2024
Indiana Clinical and Translational Sciences Institute
2012-2024
University School
2007-2024
Indiana University Bloomington
2006-2024
Riley Hospital for Children
2014-2021
University Medical Center
2002-2003
Eli Lilly (United States)
1999-2000
The amygdala is involved in the associative processes for both appetitive and aversive emotions, its function modulated by stress hormones. neuropeptide corticotrophin releasing factor (CRF) released during has been linked to many stress-related behavioral, autonomic, endocrine responses. In present study, nonanxiety-inducing doses of a potent CRF type 1 2 receptor agonist, urocortin (Ucn), was infused locally into basolateral (BLA) rats. After 5 daily injections Ucn, animals developed...
Resilience to mental and physical stress is a key determinant for the survival functioning of mammals. Although importance resilience has been recognized, underlying neural mediators have not yet identified. Neuropeptide Y (NPY) peptide known its anti-anxiety-like effects mediated via amygdala. The results our current study demonstrate, first time that repeated administration NPY directly into basolateral nucleus amygdala (BLA) produces selective stress-resilient behavioral responses an...
Acupuncture is an integrative therapy with strong evidence to support its use in the oncology setting, yet barriers exist for implementation into conventional medical clinics. Though acupuncture recommended clinical practice guidelines oncology, there little data literature showing how and other related therapies, including herbal medicine are successfully implemented some clinics, while others experience care. To characterize current of (ACU) (HM) we collected general demographic usage from...
Intravenous sodium lactate infusions or the noradrenergic agent yohimbine reliably induce panic attacks in humans with disorder but not healthy controls. However, exact mechanism of eliciting a attack is still unknown. In rats chronic disruption GABA-mediated inhibition dorsomedial hypothalamus (DMH), achieved by microinfusion glutamic acid decarboxylase inhibitor l -allylglycine, elicits panic-like responses (i.e., anxiety, tachycardia, hypertension, and tachypnea). present study, previous...
Neuropeptide Y (NPY) is one of the most abundant peptides in brain and has been shown to be a critical regulator emotionality, notably for its effect decreasing anxiety-like behaviors. The stress response both humans animals involve cascade biological events initiated by corticotropin releasing factor (CRF), another centrally acting peptide. Interestingly, NPY CRF are present similar regions mediating responses may act an opposing fashion. basolateral nucleus amygdala (BLA) distinct division...
Vincristine (VCR) is a critical part of treatment in pediatric malignancies and associated with dose-dependent peripheral neuropathy (vincristine-induced [VIPN]). Our previous findings show VCR metabolism regulated by the CYP3A5 gene. Individuals who are low expressers metabolize slower experience more severe VIPN as compared to high expressers. Preliminary observations suggest that Caucasians nonCaucasians.Kenyan children cancer were undergoing including recruited for prospective cohort...
Abstract Vincristine is a core chemotherapeutic drug administered to pediatric acute lymphoblastic leukemia patients. Despite its efficacy in treating leukemia, it can lead severe peripheral neuropathy subgroup of the Peripheral debilitating and painful side-effect that severely impact an individual’s quality life. Currently, there are no established predictors incidence during early stage treatment. As result, patients who not susceptible may receive sub-therapeutic treatment due empirical...
Vincristine is one of the core chemotherapy agents used in treatment pediatric acute lymphoblastic leukemia ( ALL ). However, major toxicities resulting from vincristine exposure vincristine‐induced peripheral neuropathy VIPN When results significant morbidity, dose may need to be reduced, thus potentially decreasing effectiveness treatment. To date, there are no robust biomarkers clinically determine which patients will at risk for worse neuropathy. The current study included genomewide...
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Vincristine a core chemotherapeutic agent for patients with ALL; unfortunately, ∼78% will develop vincristine-induced peripheral neuropathy (VIPN). VIPN can result in vincristine dose reductions that decrease therapeutic efficacy: making it important to understand which children are at highest risk VIPN. We hypothesized ALL who were obese diagnosis would worse than healthy weight within first year. Our results confirmed...