A5090468155- COVID-19 Clinical Research Studies
- Sodium Intake and Health
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- SARS-CoV-2 and COVID-19 Research
- Erythropoietin and Anemia Treatment
- Blood Pressure and Hypertension Studies
- Iron Metabolism and Disorders
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Potassium and Related Disorders
- Cardiovascular and exercise physiology
- Renal Diseases and Glomerulopathies
- Vaccine Coverage and Hesitancy
- Renal and Vascular Pathologies
- Intensive Care Unit Cognitive Disorders
- Diabetes Management and Research
- Ion Transport and Channel Regulation
- Influenza Virus Research Studies
- Central Venous Catheters and Hemodialysis
- COVID-19 and healthcare impacts
- Diet and metabolism studies
Epsom and St Helier University Hospitals NHS Trust
2014-2025
National Health Service
2020-2024
University of Oxford
2023
King's College Hospital
2022
St George’s University Hospitals NHS Foundation Trust
2021
Guy's and St Thomas' NHS Foundation Trust
2021
University College London
2021
Salford Royal NHS Foundation Trust
2021
Royal Free London NHS Foundation Trust
2021
St Helier Hospital
2008-2020
Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains full-length spike glycoprotein prototype strain plus Matrix-M adjuvant, showed was safe and associated with robust immune response in healthy adult participants. Additional were needed regarding efficacy, immunogenicity, safety this larger population.In phase 3, randomized, observer-blinded, placebo-controlled...
High blood pressure and proteinuria are the major risk factors for cardiovascular renal disease. In black individuals, there is an increased of hypertension, stroke, heart failure, kidney There no controlled studies effects reducing salt intake on urine protein excretion in individuals. Therefore, aim our study was to determine modest restriction nondiabetic hypertensive subjects. The randomized, double blind, placebo controlled. After run-in periods their usual diet reduced salt,...
Abstract Background The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against coronavirus disease 2019 (COVID-19) in a phase 3, randomized, observer-blinded, placebo-controlled trial the United Kingdom. protocol was amended to include blinded crossover. Data end of are reported. Methods Adults aged 18–84 years received 2 doses NVX-CoV2373 or placebo (1:1) and were monitored for virologically confirmed mild, moderate, severe COVID-19 (onset from 7 days after...
The cardiovascular and kidney benefits of sodium-glucose co-transporter-2 (SGLT2) inhibitors in people with chronic disease (CKD) are well established. implementation updated SGLT2 inhibitor guidelines prescribing the real-world CKD population remains largely unknown.
Observational studies suggest sodium-glucose co-transporter 2 (SGLT2) inhibitor kidney outcome trials are not representative of the broader population people with chronic disease (CKD). However, there limited data on generalizability to those without co-existing type diabetes (T2D), and representativeness Study Heart Kidney Protection Empagliflozin (EMPA-KIDNEY) trial has been adequately explored. We hypothesized that SGLT2 more T2D than without, EMPA-KIDNEY is previous trials.
The objective was to assess the role of office and ambulatory blood pressure (BP) on development end-stage renal disease (ESRD) in nondiabetic chronic failure.Seventy-nine patients [mean age 57 (standard deviation 11) years, 47 men, BMI 28 (4), BP 151 (25)/92 (14) mmHg, estimated glomerular filtration rate ml/min per 1.73 m3] were included. causes nephrosclerosis (n = 33), glomerulonephritis 19), interstitial 12) others 15). average follow-up 44 months (range 9-72 months). primary outcome a...
ABSTRACT Background Non-anaemic iron deficiency is highly prevalent in people living with chronic kidney disease (CKD) but underdiagnosed and undertreated, especially earlier stages of CKD. A multicentre trial assessing the effect intravenous supplementation iron-deficiency not anaemic CKD included a qualitative sub-study that aimed to explore patient experience psychosocial impact deficiency, therapeutic intervention (intravenous exercise). Methods Semi-structured interviews were conducted...
Accurately identifying cases of chronic kidney disease (CKD) from primary care data facilitates the management patients, and is vital for surveillance research purposes. Ontologies provide a systematic transparent basis clinical case definition can be used to identify codes relevant all aspects CKD its diagnosis. We routinely collected Royal College General Practitioners Research Surveillance Centre. A domain ontology was created presented in Ontology Web Language (OWL). The identification...
Abstract To investigate the symptoms of SARS-CoV-2 infection, their dynamics and discriminatory power for disease using longitudinally, prospectively collected information reported at time occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was predominant strain. Participants were assessed infection via nasal/throat PCR recruitment, vaccination appointments, when symptomatic. Statistical techniques implemented to infer estimates...
Plasma sodium is increased following each meal containing salt. There an increasing interest in the effects of plasma concentration, and it has been suggested that may have direct on blood pressure (BP) possibly influences endothelial function. Experimental increases concentration rapidly raise BP even when extracellular volume falls. Ten patients with end-stage renal failure established haemodialysis were studied during first 2 h dialysis without fluid removal this period. They randomized...
<h3>ABSTRACT</h3> High salt intake is now endemic worldwide. It contributes to the generation and maintenance of high blood pressure, which biggest risk factor for global disease. There compelling evidence support reduction in hypertensives a substantial body general population reduce death from cardiovascular In specific diseases such as heart failure chronic kidney disease, guidelines World Health Organization target reduced at 5 g daily. Achieving diet that lower has challenges, but...
ABSTRACT Background Covid-19 vaccines are urgently needed, especially against emerging variants. NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 rS) nanoparticle vaccine containing trimeric full-length SARS-CoV-2 spike glycoprotein and Matrix-M adjuvant. Methods A phase 3, randomized, observer-blinded, placebo-controlled trial was conducted in adults 18-84 years old who received two intramuscular 5-µg doses, 21 days apart, of or placebo (1:1) across...
Patients with chronic kidney disease (CKD) are often iron deficient, even when not anemic. This trial evaluated whether supplementation enhances exercise capacity of nonanemic patients CKD who have iron-deficiency.Prospective, multicenter double-blind randomized controlled nondialysis and iron-deficiency but without anemia (Hemoglobin [Hb] >110 g/l). were assigned 1:1 to intravenous (IV) therapy, or placebo. An 8-week program commenced at week 4. The primary outcome was the mean...
Abstract Aim Chronic kidney disease ( CKD ) is increasing in prevalence and associated with cardiovascular events mortality asymptomatic vascular surgery populations. This study aimed to determine the role of stratifying peri‐ postoperative risk for colorectal cancer CRC patients nonmetastatic undergoing elective curative resection. Method Patients diagnosed adenocarcinoma surgical resection between 2006 2011 were identified from a prospectively collated database. Further information on...
Summary Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza has not yet been reported. Methods A sub-study on vaccine co-administration was conducted as part the phase 3 randomized trial efficacy NVX-CoV2373. first ∼400 participants meeting main study entry criteria no contraindications to vaccination were invited join sub-study. After randomization in a 1:1 ratio receive NVX-CoV2373 (n=217) or placebo (n=214),...
Higher serum sodium concentration has been reported to be a risk factor for the development of incident chronic kidney disease (CKD), but its relationship with progression established CKD not investigated. We hypothesised that increased is estimated glomerular filtration rate (eGFR) decline in CKD.This was retrospective cohort study using data collected over 6-year period, baseline obtained during first 2 years. included patients known our renal service who had minimum three blood tests...
Patients on dialysis with frequent comorbidities, advanced age, and frailty, who visit treatment facilities frequently, are perhaps more prone to SARS-CoV-2 infection related death-the risk factors dynamics of which unknown. The aim this study was investigate the hospital outcomes in patients infected SARS-CoV-2.Data 224 hemodialysis between February 29, 2020 May 15, confirmed were analyzed for potential death, using a competing risk-regression model assessed by subdistribution hazards ratio...