A5101635757- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- Reproductive tract infections research
- Nausea and vomiting management
- HIV Research and Treatment
- Reproductive Health and Contraception
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Syphilis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Innovations in Medical Education
- Hip disorders and treatments
- Bone and Joint Diseases
- Vaccine Coverage and Hesitancy
- Pituitary Gland Disorders and Treatments
- Palliative Care and End-of-Life Issues
- Colorectal and Anal Carcinomas
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- HIV, Drug Use, Sexual Risk
- Antibiotic Use and Resistance
- Neurological Complications and Syndromes
University Hospitals of Morecambe Bay NHS Foundation Trust
2022
Royal Lancaster Infirmary
2020-2022
Lancaster University
2021-2022
Imperial College London
2019-2022
Universitat de Barcelona
2022
St George’s University Hospitals NHS Foundation Trust
2021
Guy's and St Thomas' NHS Foundation Trust
2021
University College London
2021
Salford Royal NHS Foundation Trust
2021
Royal Free London NHS Foundation Trust
2021
Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains full-length spike glycoprotein prototype strain plus Matrix-M adjuvant, showed was safe and associated with robust immune response in healthy adult participants. Additional were needed regarding efficacy, immunogenicity, safety this larger population.In phase 3, randomized, observer-blinded, placebo-controlled...
Abstract Background The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against coronavirus disease 2019 (COVID-19) in a phase 3, randomized, observer-blinded, placebo-controlled trial the United Kingdom. protocol was amended to include blinded crossover. Data end of are reported. Methods Adults aged 18–84 years received 2 doses NVX-CoV2373 or placebo (1:1) and were monitored for virologically confirmed mild, moderate, severe COVID-19 (onset from 7 days after...
The Valneva COVID-19 vaccine (VLA2001; Austria, Vienna, Austria) is an inactivated whole-virus, adjuvanted SARS-CoV-2 vaccine. We aimed to assess the safety and immunogenicity of primary vaccination with VLA2001 versus ChAdOx1-S (Oxford-AstraZeneca) adenoviral-vectored vaccine.In this immunobridging phase 3 trial (COV-COMPARE), participants aged 18 years older who were medically stable (as determined by investigator) enrolled at 26 sites in UK. In double-blind, randomised, controlled arm...
Combinations of metoclopramide and dexamethasone given intravenously control vomiting caused by high doses cisplatin. Lorazepam diphenhydramine are useful adjuncts to antiemetics. In a double-blind trial, 120 patients receiving high-dose cisplatin (120 mg/m2) for the first time were randomly assigned receive either lorazepam (1.5 or (50 mg) intravenously, 45 minutes prior addition, all received intravenous (20 40 chemotherapy along with (3 mg/kg) 30 before 90 after Patients directly observed...
There currently is no pharmacologic approach to the problem of anticipatory nausea and vomiting (ANV). Lorazepam (Ativan, Wyeth Laboratories, Philadelphia) an interesting candidate drug if it could block recall unpleasant events associated with chemotherapy, especially also has antiemetic properties. Since ANV a conditioned (learned) response, may well depend on memory imprint stimulus. This pilot study was designed use intravenous lorazepam given before after cisplatin infusion in 32...
Objective: To determine if the metronidazole (MTZ) 2-gm single dose (recommended) is as effective 7-day 500 mg twice a day (alternative) for treatment of Trichomonas vaginalis (TV) among HIV+ women. Methods: Phase IV randomized clinical trial; women with culture confirmed TV were to arm: MTZ or dose. All given doses deliver their sex partners. Women recultured at test-of-cure (TOC) visit occurring 6-12 days after completion. TV-negative TOC again 3-month visit. Repeat infection rates...
Abstract Background Omicron-containing bivalent boosters are available worldwide. Results of a large, randomized, active-controlled study presented. Methods This phase 3, observer-blind, trial in the United Kingdom evaluated immunogenicity and safety 50-µg doses omicron-BA.1-monovalent mRNA-1273.529 mRNA-1273.214 booster vaccines compared with mRNA-1273 administered as individuals ≥16 years. Participants had previously received 2 any authorized/approved Covid-19 vaccine or without an mRNA...
Abstract To investigate the symptoms of SARS-CoV-2 infection, their dynamics and discriminatory power for disease using longitudinally, prospectively collected information reported at time occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was predominant strain. Participants were assessed infection via nasal/throat PCR recruitment, vaccination appointments, when symptomatic. Statistical techniques implemented to infer estimates...
ABSTRACT Background Covid-19 vaccines are urgently needed, especially against emerging variants. NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 rS) nanoparticle vaccine containing trimeric full-length SARS-CoV-2 spike glycoprotein and Matrix-M adjuvant. Methods A phase 3, randomized, observer-blinded, placebo-controlled trial was conducted in adults 18-84 years old who received two intramuscular 5-µg doses, 21 days apart, of or placebo (1:1) across...
Summary: To better understand potential barriers to condom use and the sexual behaviour of women infected with human immunodeficiency virus (HIV), an anonymous self-administered survey was performed on a convenience sample 83 predominantly single HIV+ women. Most had only one partner who usually knew subject's serostatus. Only minority partners (26%) were known also be HIV infected. Subjects surprisingly more likely condoms their main as opposed other partners. Factors found associated...
This study examined the prevalence and factors associated with Mycoplasma genitalium (MG) infection among HIV-positive women association between MG vaginal HIV-1 RNA shedding. attending an outpatient clinic in New Orleans, Louisiana, USA, from 2002 to 2005 were for a battery of sexually transmitted infections (STIs) underwent behavioural survey. A selected subset had measurement shedding analysed. Of 324 women, 32 (9.9%) infected MG. more likely be co-infected Neisseria gonorrhoeae Chlamydia...
<h3>Background</h3> Weight loss is associated with accelerated mortality and disease progression in patients human immunodeficiency virus (HIV) infection. Although studies have examined a variety of anabolic therapies HIV-infected men, the safety efficacy such treatments women not been adequately studied. <h3>Methods</h3> In this randomized, double-blind, placebo-controlled, multicenter, phase I/II study, 38 documented weight 5% or greater preceding year body mass index less than 20...
The purpose of this study was to examine the association between alcohol consumption and HIV-1 vaginal shedding.HIV-1 infected women attending a large urban HIV primary care clinic in New Orleans, LA, June 2002 October 2004 who underwent gynecological exam, were 18 years age or older, provided informed consent included. Subjects exams interviewed using computer-assisted survey at baseline, 1 month, 3 months.Most black (86.4%), with median 38 (range: 19-61 years). Most (56.7%) also on...
Objectives The aim of the study was to evaluate long‐term changes in lipids and assess other coronary heart disease (CHD) risk factors highly experienced AIDS patients with immune reconstitution, examine their association antiretroviral therapy (ART). Methods We evaluated 433 prior severe immunosuppression ART‐based followed a multicentre prospective observational between 2000 2006. estimated prevalence at entry hypercholesterolaemia metabolic syndrome, 10‐year CHD risks. Trends total...
We assessed whether HIV status was associated with white matter hyperintensities (WMH), a neuroimaging correlate of cerebral small vessel disease (CSVD), in men aged ≥50 years. A cross-sectional substudy nested within larger cohort study. Virologically suppressed living (MLWH) and demographically matched HIV-negative underwent magnetic resonance imaging (MRI) at 3 Tesla. Sequences included volumetric three-dimensional (3D) T1-weighted, fluid-attenuated inversion recovery pseudocontinuous...
Diarrhea commonly occurs following the administration of cisplatin. BW942C, a pentapeptide, is synthetic enkephalin shown to control castor oil-induced and traveler's diarrhea. To assess safety efficacy BW942C in controlling diarrhea caused by cisplatin, 30 adults with lung cancer who had already experienced (three or more loose bowel movements) during 24-hour period prior cisplatin were randomized receive either placebo next course. All patients received concomitant antiemetic regimen...
The objective of this randomized, double-blind, controlled multicentre study was to evaluate the efficacy saquinavir alone or in combination with zalcitabine compared monotherapy reducing progression human immunodeficiency virus (HIV) disease. Nine hundred and forty HIV-infected patients more than 16 weeks prior zidovudine therapy pre-study entry CD4 cell counts between 50 300 cells/mm 3 were randomized 600 mg every 8 h, 0.75 h both drugs. In an intent-to-treat analysis, treatment arms...
Low levels of serum testosterone may have negative implications on morbidity in HIV-infected men. The purpose this study was to determine demographic and clinical characteristics that predict low among men attending our HIV clinic. A cross-sectional 587 HIV-positive male patients who presented at the Louisiana State University Outpatient (HOP) Clinic between August 1997 January 1999 conducted. Demographic were collected analysed. Of studied, 119 (20.3%) had a level below 400 ng/dl....
Women coinfected with human immunodeficiency virus (HIV) and Trichomonas vaginalis who are treated 2 grams metronidazole (MTZ) more likely to have persistent infections if they receiving antiretroviral therapy compared similar women multidose MTZ. Objective. Among positive (HIV+), both prevalent (TV) common. TV has been shown increase vaginal shedding of HIV, which may influence HIV sexual perinatal transmission, making prevention important. In 1 cohort HIV+ in Kenya, (ART) use, mostly...
Rituximab is an antibody that binds to B-lymphocytes and increasingly used during pregnancy. As immunoglobulin G, it will transfer across the placenta. Previous case reports describe a diversity of clinical presentations in neonates born following rituximab exposure utero. Our first offer long-term experience care infant with severe neutropenia prolonged profound hypogammaglobulinemia class-switching B cell defect after utero exposure.
To identify the prognostic significance of hemophilia- and virus-related factors, authors undertook a survival analysis among 644 human immunodeficiency virus (HIV)-infected subjects enrolled in Multicenter Hemophilia Cohort Study between 1985 1993. Acquired syndrome (AIDS) was leading cause death, followed by hemorrhage hepatic disease. Adverse factors included older age CD4-positive lymphocyte values below 14 percent either at entry (age-adjusted mortality rate ratio (RR) = 6.4, 95%...