A5079174805- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Pregnancy and Medication Impact
- Bone health and osteoporosis research
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Palliative Care and End-of-Life Issues
- Hemoglobinopathies and Related Disorders
- Vitamin D Research Studies
- HIV/AIDS Research and Interventions
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- Health Systems, Economic Evaluations, Quality of Life
St George’s University Hospitals NHS Foundation Trust
2014-2025
The Royal Free Hospital
2024
Roland Hill (United Kingdom)
2024
University College London
2024
Cardiff University
2024
University of Ibadan
2023
St George's, University of London
2014-2023
National Health Service
2020-2022
St George's Hospital
2012-2021
South West London and St George's Mental Health NHS Trust
2012-2020
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated part by concerns of disproportionately more severe among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors mortality SOT recipients are not well described. Methods We performed a multicenter cohort study with laboratory-confirmed COVID-19. Data were collected using standardized intake 28-day follow-up electronic case...
By 21 March 2020 infections related to the novel coronavirus SARS-CoV-2 had affected people from 177 countries and caused 11,252 reported deaths worldwide. Little is known about risk, presentation outcomes of (COVID-19) infection in kidney transplantation recipients, who may be at high-risk due long-term immunosuppression, comorbidity residual chronic disease. Whilst COVID-19 predominantly a respiratory disease, severe cases it can cause multi-organ failure. It unknown if immunocompromised...
T cell Ig mucin 1 (TIM-1) plays an important role in regulating immune responses autoimmune and asthma models, it is expressed on both Th1 Th2 cells. Using antagonistic TIM-1–specific antibody, we studied the of TIM-1 alloimmunity. A short course antibody monotherapy prolonged survival fully MHC-mismatched vascularized mouse cardiac allografts. This prolongation was associated with inhibition alloreactive preservation responses. treatment more effective Th1-type cytokine–deficient Stat4–/–...
The risk of COVID-19 infection in transplant recipients (TRs) is unknown. Patients on dialysis may be exposed to greater due an inability isolate. Consideration these competing risks important before restarting suspended programs. This study compared outcomes kidney and kidney/pancreas TRs with those the waiting list, following admission a high-prevalence region.Audit data from all 6 London centers were amalgamated. Demographic laboratory collected included mortality, intensive care (ITU)...
Background— Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play critical role initiation allograft rejection and vasculopathy. The negative T-cell costimulatory pathway PD-1:PDL1/PDL2 (programmed death-1:programmed death ligand-1/2) plays an important regulating alloimmune responses. We investigated recipient versus donor PD-1 ligands pathogenesis with emphasis on tissue expression this response vivo. Methods Results— used...
Objective: To summarize antiretroviral therapy (ART) use in the setting of end-stage kidney disease (ESKD). Design: Cross-sectional analysis. Methods: Descriptive analysis ART regimens and dose nucleoside/nucleotide reverse-transcriptase inhibitors (NRTI) people with HIV ESKD (dialysis, transplantation, or estimated glomerular filtration rate (eGFR) <15 mL/min/1.73m 2 ) receiving renal care at five London centres. Exposures interest were dual/unboosted higher than recommended doses...
The ability to induce durable transplantation tolerance predictably and consistently in the clinic is a highly desired but elusive goal. Progress hampered by lack of appropriate experimental models which study resistance tolerance. Here, we demonstrate that T helper 1-associated box 21 transcription factor (Tbet) KO recipients exhibit allograft specifically mediated IL-17-producing CD8 (T17) cells. Neutralization IL-17 facilitates long-term cardiac survival with combined cell co-stimulation...
Background IL-9 is a growth factor for T- and mast-cells that secreted by human Th2 cells. We recently reported IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit inflammatory producing CD4+ Methodology/Principal Findings Here we show inducible regulatory (iTregs) also express IL-9. induced higher levels of expression in plate bound-anti-CD3 mAb (pbCD3)/soluble-anti-CD28 (sCD28) activated resting memory CD4+CD25−CD45RO+ as compared naïve CD4+CD25−CD45RA+ In addition, pbCD3/sCD28 plus...
Older adults with chronic kidney disease (CKD) can have low bone mineral density (BMD) concurrent vascular calcification. Mineral accrual by the growing skeleton may protect young people CKD from extraosseous Our hypothesis was that children and increasing BMD do not develop calcification.This a multicenter longitudinal study in (5-30 years) stages 4 to 5 or on dialysis. assessed tibial peripheral quantitative computed tomography (pQCT) lumbar spine dual-energy X-ray absorptiometry (DXA)....
Patients taking mesalazine should have renal function monitored regularly to avoid nephrotoxicity Mesalazine is widely prescribed for the treatment of inflammatory bowel disease. It a single molecule 5-aminosalicylic acid (5-ASA), and structurally similar phenacetin aspirin. Occasionally, with may lead severe indolent interstitial nephritis causing appreciable morbidity. Unless detected treated early this progress end stage failure despite withdrawal drug.1 obvious from increasing number...
Abstract Background. Biomarkers and dual-energy X-ray absorptiometry (DXA) are thought to be poor predictors of bone mineral density (BMD). The Kidney Disease: Improving Global Outcomes guidelines suggest using DXA if the results will affect patient management, but this has not been studied in children or young adults whom accretion continues 30 years age. We clinical utility serum biomarkers against tibial cortical BMD (CortBMD) measured by peripheral quantitative computed tomography,...
Blockade of the B7: CD28 costimulatory pathway has emerged as a promising therapy to prevent allograft rejection. However, this also been demonstrated be important for generation and maintenance regulatory T cells. In study, we investigated role in 'bm12 into B6' MHC class II-mismatched vascularized cardiac transplant model chronic Allograft rejection was remarkably accelerated B6 background B7DKO CD28KO recipients compared with wild-type (WT) recipients. associated significantly enhanced...
Patients on dialysis with frequent comorbidities, advanced age, and frailty, who visit treatment facilities frequently, are perhaps more prone to SARS-CoV-2 infection related death-the risk factors dynamics of which unknown. The aim this study was investigate the hospital outcomes in patients infected SARS-CoV-2.Data 224 hemodialysis between February 29, 2020 May 15, confirmed were analyzed for potential death, using a competing risk-regression model assessed by subdistribution hazards ratio...
Abstract Background The efficacy and safety of minimisation immunosuppression including early steroid withdrawal in kidney transplant recipients treated with Basiliximab induction remains unclear. Methods This retrospective cohort study reports the outcomes from 298 consecutive renal transplants performed since 1st July 2010–June 2013 low immunological risk patients using a simple stratification 3-month protocol biopsy to optimise therapy. comprised 225 low-risk (first or HLA antibody...
My Kidneys & Me (MK&M), a digital health intervention delivering specialist and lifestyle education for people with CKD, was developed its effects tested (SMILE-K trial, ISRCTN18314195, 18/12/2020). 420 adult patients CKD stages 3-4 were recruited randomised 2:1 to (MK&M) (n = 280) or control 140) groups. Outcomes, including Patient Activation Measure (PAM-13), collected at baseline 20 weeks. Complete case (CC) per-protocol (PP) analyses conducted. 210 (75%) participants used MK&M more than...
Cardiovascular disease (CVD) is a common cause of morbidity and mortality even in young people with chronic kidney (CKD). We examined structural functional CV changes patients ˂30 years age CKD Stages 4 5 on dialysis.A total 79 children 21 adults underwent cardiac computed tomography for coronary artery calcification (CAC), ultrasound carotid intima-media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV) echocardiography. Differences (CAC, cIMT z-score, left ventricular mass...
Tacrolimus is the key component of most contemporary immunosuppressive drug regimens for prevention transplant rejection. Area under concentration time curve over 24 h (AUC0-24 ) predicts efficacy, but predose (trough) tacrolimus blood (C0 currently used to guide dosing. In clinical or research situations where an estimate AUC required, collection a full pharmacokinetic (PK) profile cumbersome. Limited sampling strategies (LSSs) have been developed some preparations not new,...
Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this due to the underlying metabolic disorder itself or occurs as a consequence dietary restriction has yet elucidated. Skin biopsies typically show histological features shared by number disorders nutritional deficiency‐associated...