A5101867792- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Curcumin's Biomedical Applications
- Surgical site infection prevention
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
- Image Processing Techniques and Applications
- Dementia and Cognitive Impairment Research
- Galectins and Cancer Biology
- Infrared Thermography in Medicine
- Allergic Rhinitis and Sensitization
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Sperm and Testicular Function
- Tuberculosis Research and Epidemiology
- interferon and immune responses
Affiliated Hospital of Jiangsu University
2020-2023
Jiangsu University
2020-2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
Shanghai First People's Hospital
2021
Shanghai Cell Therapy Research Institute
2021
Nanjing Medical University
2021
Huazhong University of Science and Technology
2017
Tongji Hospital
2017
Harvard University
2009-2013
Blockade of the B7:CD28 costimulatory pathway has emerged as a promising therapy to prevent allograft rejection. However, results from belatacept phase III clinical trial demonstrated higher rejection rate when compared cyclosporine, raising concern about potential deleterious effects this agent. In study, we investigated consequences blockade by hCTLA4Ig on regulator T cell (Treg) generation in different major histocompatibility complex (MHC) mismatch transplant models. Administration...
Abstract The programmed death ligand 1 (PDL1)/programmed (PD1) costimulatory pathway plays an important role in the inhibition of alloimmune responses as well induction and maintenance peripheral tolerance. It has been demonstrated recently that PDL1 also can bind B7.1 to inhibit T cell vitro. Using bm12 into B6 heart transplant model, we investigated functional significance this interaction vivo. PD1 blockade unlike failed accelerate allograft rejection, suggesting a for additional binding...
To compare the diagnostic accuracies of Revised Hasegawa Dementia Scale (HDS-R) and Mini-Mental Status Examination (MMSE) for Alzheimer’s diseases (AD), we administered them simultaneously to 82 AD patients age- sex-matched nondemented control subjects. The area under receiver operator curve (AUC) HDS-R (AUC<sub>HDS-R</sub>) MMSE (AUC<sub>MMSE</sub>) were bigger than 0.90 indicating that both tests are useful detecting AD. However, AUC<sub>HDS-R</sub>...
Long noncoding RNAs (lncRNAs) have been increasingly recognized as key immune molecules that participate in the pathogenesis of autoimmune diseases. Previous studies demonstrated lncRNA Ifng-AS1, a scaffold contributes to transcription IFN- γ , depends on T-bet for active Th1 cells. However, effect its human ortholog, IFNG-AS1, rheumatoid arthritis (RA) remains unclear. In this study, we found transcript level IFNG-AS1 was increased peripheral blood RA patients. IFNG, target gene...
The N otch pathway is an important intercellular signaling that plays a major role in controlling cell fate. Accumulating evidence indicates and its ligands present on antigen‐presenting cells might be mediators of T helper differentiation. In this study, we investigated the J agged2 murine cardiac transplantation by using m A b ( ag2) activates recombinant signal‐binding protein‐Jκ. While administration ag2 had little effect graft survival fully allogeneic mismatched model BALB /c→ B 6, it...
Blockade of the B7: CD28 costimulatory pathway has emerged as a promising therapy to prevent allograft rejection. However, this also been demonstrated be important for generation and maintenance regulatory T cells. In study, we investigated role in 'bm12 into B6' MHC class II-mismatched vascularized cardiac transplant model chronic Allograft rejection was remarkably accelerated B6 background B7DKO CD28KO recipients compared with wild-type (WT) recipients. associated significantly enhanced...
Acute graft-versus-host disease (aGVHD) is one of the most common complications allogeneic hematopoietic stem cell transplantation (allo-HSCT). Janus kinase (JAK) inhibitors are considered as reliable and promising agents for patients with aGVHD. The prophylactic therapeutic effects SHR0302, a novel JAK inhibitor, were evaluated in aGVHD mouse models. overall survival (OS), progression-free (PFS), bodyweight mice, GVHD scores observed recorded. bone marrow spleen samples diseased model mice...
The present study aimed to discriminate different subsets of cultured dendritic cells (DCs) evaluate their immunological characteristics. DCs offer an important foundation for studies, and mouse bone marrow (BM) with granulocyte‑macrophage colony‑stimulating factor (GM‑CSF) have been used extensively generate CD11c+/major histocompatibility complex II+ BM‑derived (BMDCs). Immature are considered strong migration phagocytic antigen‑capturing abilities, whereas mature thought activate naive T...
Allergic rhinitis (AR) is characterized by type I hypersensitivity that mediated IgE-induced humoral responses. Follicular helper T cells (Tfh) comprise the key cell (Th) subset promotes antibody production. Signaling lymphocytic activation molecules (SLAMs) participate in regulation of differentiation and function Tfh cells, but whether this involved pathogenesis AR unknown.CD4+CXCR5+ Tfh-like from peripheral blood were detected flow cytometry. The IL-21 IgE levels serum measured an ELISA....
Macrophages preferentially polarize to the anti-inflammatory M2 subtype in response alterations wound microenvironment. SUMO-specific protease 3 (SENP3), a protease, has been proven regulate inflammation macrophages by deSUMOylating substrate proteins, but its contribution healing is poorly defined. Here, we report that SENP3 deletion promotes macrophage polarization and accelerates macrophage-specific knockout mice. Notably, it affects through suppression of promotion angiogenesis collagen...
Background. Long noncoding RNAs (lncRNAs) represent an important novel class of RNA molecule greater than 200 nucleotides that play a key role in the regulation autoimmune diseases. Previous studies have demonstrated MAFTRR (MAF transcriptional regulator RNA) regulated Th1 cells differentiation by inhibiting expression MAF activated CD4+ T cells. However, effect on pathogenesis Hashimoto’s thyroiditis (HT) remains unclear. This research was aimed at investigating as well correlation between...
Signaling lymphocytic activation molecule (SLAM) and SLAM-associated protein (SAP) play important role in inflammatory autoimmune diseases. Our study is aimed at detecting the expression of SLAM SAP patients with Graves’ disease (GD) analyzing effect SLAM/SAP on circulating blood CD4+CXCR5+Foxp3+ follicular regulatory T (Tfr) cells. The level CD4+CXCR5+ cells CD19+ B were significantly increased GD, but no significant difference was observed between GD healthy controls. A decrease percentage...