A5062327534- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Organ Donation and Transplantation
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Nephrotoxicity and Medicinal Plants
- Vaccine Coverage and Hesitancy
- Transplantation: Methods and Outcomes
- Heavy Metals in Plants
- Eosinophilic Esophagitis
- Palliative Care and End-of-Life Issues
- Cancer Immunotherapy and Biomarkers
- Medical and Health Sciences Research
- Foreign Body Medical Cases
- Effects of Environmental Stressors on Livestock
- Vector-Borne Animal Diseases
- Inflammatory Myopathies and Dermatomyositis
- Neurological Complications and Syndromes
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Mast cells and histamine
Kahramanmaraş Sütçü İmam University
2024
Guy's and St Thomas' NHS Foundation Trust
2019-2022
Guy's Hospital
2019-2022
St Thomas' Hospital
2014-2021
King's College London
2008-2019
Balıkesir University
2009-2015
Innate Pharma (France)
2010-2014
Université Libre de Bruxelles
2013
UCLouvain
2013
Imperial College London
2013
T-bet and GATA3 regulate the CD4+ T cell Th1/Th2 fate decision but little is known about interplay between these factors outside of murine Ifng Il4/Il5/Il13 loci. Here we show that bind to multiple distal sites at immune regulatory genes in human effector cells. These display markers functional elements, act as enhancers reporter assays are associated with a requirement for GATA3. Furthermore, demonstrate both Tbx21 directly activates its own expression. We also Th1 cells, distributed away...
Mice lacking the transcription factor T-bet in innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα+ lymphoid cells (ILCs) were potent promoters of disease Tbx21−/−Rag2−/− ulcerative colitis (TRUC) mice. TNF-α produced by CD103−CD11b+ dendritic synergized with IL-23 to drive IL-17A production ILCs, demonstrating a previously unrecognized layer cellular crosstalk between and ILCs. We have identified Helicobacter typhlonius as...
Tregs play a fundamental role in immune tolerance via control of self-reactive effector T cells (Teffs). This function is dependent on maintenance high intracellular cAMP concentration. A number microRNAs are implicated the Tregs. In this study, we demonstrate that peripheral critically posttranscriptional repression cAMP-hydrolyzing enzyme phosphodiesterase-3b (Pde3b) by microRNA-142-5p (miR-142-5p). manner, miR-142-5p acts as an immunometabolic regulator cAMP, controlling Treg suppressive...
The complex relationship between Th1 and Th17 cells is incompletely understood. transcription factor T-bet best known as the master regulator of lineage commitment. However, attention now focused on repression alternate T cell subsets mediated by T-bet, particularly lineage. It has recently been suggested that pathogenic express are dependent IL-23. previously shown to be a negative cells. We have taken an unbiased approach determine functional impact Genome-wide analysis binding sites...
The objective of this study was to determine the fitness Quadratic, Cubic, Gompertz and Logistic functions growth curves Konya Merino lambs obtained by using monthly records live weight from birth 480 days age. models were evaluated according determination coefficient (R2), mean square prediction errors (MSPE) Durbin Watson (DW) statistics. R2 values ranged 0.96 0.99 for females males. Cubic model gave best value in females, while lowest females. results indicated that Quadratic showed fit...
Introduction Bluetongue (BT) is a non‐contagious infectious disease of ruminants. The agent bluetongue virus (BTV) classified in the Reoviridae family Orbivirus . Aims and objectives aim this study was to determine serum malondialdehyde (MDA), total antioxidative stres (TAS), sialic acid (TSA), ceruloplasmin, triglyceride, alanine aminotransferase (ALT), aspartate (AST), γ‐glutamyltransferase (GGT), cholesterol, creatinine, albumin, protein levels sheep with without (BT). Materials Methods...
We report a case of severe hypercalcaemia secondary to rhabdomyolysis in woman with COVID-19 (SARS CoV-2) infection. The patient presented myalgia and anuria an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. A biphasic calcaemic response was observed initial hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite Control the calcium levels achieved continuous haemofiltration.
Genetically determined hypoparathyroidism can lead to life-threatening episodes of hypocalcemia and, more rarely, end-stage kidney disease at a young age. Parathyroid allotransplantation is the only curative treatment, and in patients already receiving immunosuppression for transplantation, there may be little additional risk involved. We report first such case child.An 11-y-old girl, known have secondary an activating pathogenic variant calcium-sensing receptor, developed was started on...
To enhance outcomes for patients with pulmonary arterial hypertension (PAH), comprehensive and individualized therapy is needed. A large language model called Generative Pre-trained Transformer (ChatGPT) has the ability to provide expert yet patient-friendly care. We wanted determine how well ChatGPT could accurately consistently respond inquiries on knowledge management PAH.
A 51-year-old man was brought to the emergency department after he had drunk 200 mL of fluid from a decorative sparkle lamp. His calcium level 4.99 mmol/L with blood gas pH 7.21. levels were corrected and his acidosis improved, but stay in intensive care complicated on day 10 by upper gastrointestinal hemorrhage because caustic erosions stomach. Ten days admission, an right hemicolectomy during which residual luminescent particles found have eroded through cecal mucosa. He eventually died 15...
Assessment of future risk end-stage renal disease (ESRD) is an important component evaluation potential living kidney donors.Known donor factors for ESRD include first-degree relatives, young age, male sex and African descent [1].In the general population, presence two apolipoprotein L1 (APOL1) alleles a key determinant excess incidence observed in Americans [2].In donors, effect APOL1 genotype on developing unknown.However, higher black donors faster decline estimated glomerular filtration...