A5001812735- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Hemoglobinopathies and Related Disorders
- Liver Disease and Transplantation
- Iron Metabolism and Disorders
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Breast Cancer Treatment Studies
- Advances in Oncology and Radiotherapy
- Nutrition and Health in Aging
- Diversity and Career in Medicine
- Health and Medical Research Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid and Parathyroid Surgery
- Healthcare cost, quality, practices
- Palliative Care and End-of-Life Issues
- Erythrocyte Function and Pathophysiology
- Parathyroid Disorders and Treatments
- Digestive system and related health
- Growth Hormone and Insulin-like Growth Factors
- Healthcare Systems and Challenges
- Epigenetics and DNA Methylation
Guy's Hospital
2022
University of Oxford
2014-2021
Portsmouth Hospitals NHS Trust
2021
Churchill Hospital
2014-2021
Nuffield Orthopaedic Centre
2021
Oxford BioMedica (United Kingdom)
2016
John Radcliffe Hospital
2015
Oxford University Hospitals NHS Trust
2014
University of Southampton
2012
Southampton General Hospital
2012
The increased demand for organs has led to the usage of "higher risk" kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible preservation injury have a higher risk unfavorable outcomes. Dynamic, instead static, could allow organ optimization, offering platform viability assessment, active repair resuscitation. Ex situ machine perfusion in regional donor emerging as potential tools preserve resuscitate vulnerable...
The gap between supply and demand in kidney transplantation has led to increased use of marginal kidneys; however, kidneys with acute injury are often declined/discarded. To determine whether this policy is justified, we analyzed outcomes donor (AKI) a large UK cohort. A retrospective analysis the Transplant Registry evaluated deceased donors 2003 2013. Donors were classified as no AKI, or AKI stage 1-3 according Acute Kidney Injury Network (AKIN) criteria. Relationship delayed graft...
<h3>Importance</h3> Continuous hypothermic machine perfusion during organ preservation has a beneficial effect on graft function and survival in kidney transplant when compared with static cold storage (SCS). <h3>Objective</h3> To compare the of short-term oxygenated (end-HMPo<sub>2</sub>) after SCS vs alone 1-year expanded criteria donor kidneys from donors who are brain dead. <h3>Design, Setting, Participants</h3> In prospective, randomized, multicenter trial, were randomized to either or...
Diabetes mellitus was observed in 29 of 448 patients with thalassaemia major attending seven Italian centres. Twelve patients, at onset clinical diabetes, presented an asymptomatic glycosuria, 13 ketosis, and four ketoacidosis. All were diagnosed after 1979, a mean age 17 years. Mean diagnosis diabetes lower born the last two decades. In these transfusions started younger pre-transfusion haemoglobin concentration, serum ferritin incidence liver disease, presence family history higher than...
Summary. objective Impairment of linear growth is a common clinical feature In patients with β ‐thalassaemia major. Although hormone secretion appears to be normal in many short thalassaemic patients, it proves deficient some them. these cases, administration biosynthetic seems justified. The aim this study was evaluate the effect such treatment group ‐thalassaemla major presenting failure and impairment secretion. design Recombinant human hormone, 0.6 U/kg body weight per week, given...
Background Brain death (BD) induces a profound inflammatory response affecting the quality and function of donor organs. Longer BD duration increases injury in organs, but up-regulation defence mechanisms also occurs, initiating regeneration repair. This poses question what is better for graft-to-be: retrieval organs as-soon-as-possible or wait optimise in-situ repair? Methods A retrospective analysis UK transplant registry evaluated donors after brain DBD during 2008-2012. In 1881...
Sexual harassment exists within the surgical training community and environment. This is unprofessional behaviour must raise awareness of it as well facilitating encouraging reporting with robust investigation pathways.
Genetically determined hypoparathyroidism can lead to life-threatening episodes of hypocalcemia and, more rarely, end-stage kidney disease at a young age. Parathyroid allotransplantation is the only curative treatment, and in patients already receiving immunosuppression for transplantation, there may be little additional risk involved. We report first such case child.An 11-y-old girl, known have secondary an activating pathogenic variant calcium-sensing receptor, developed was started on...
Introduction The widening gap between supply and demand in kidney transplantation has lead to the increased use of kidneys from marginal donors, including those with acute injury (AKI). Despite organ shortage, donor AKI are often declined or discarded. To determine if this policy is justified we have analysed outcomes a large UK cohort. Methods In retrospective analysis transplant registry, adult deceased donors 2003-2008 were evaluated. Donors classified as no AKI, stage 1, 2 3 according...
Besides facilitating closure, the advent of abdominal wall transplantation (AWTx) is proving a promising asset for early, patient led rejection monitoring. We performed retrospective case notes analysis all patients undergoing intestinal and composite tissue allograft transplantation. Clinical presentation was correlated with histology, stoma output, citrulline levels endoscopy findings. From October 2008 to November 2013, 24 underwent (ITx) in our institute. Mean age 42±2.8 years (range 23-...
Background and Aims There is a general perception that viscous solutions reduce the rate at which blood washed out of organs during cold flush procurement, inhibit efficient cool-down, prohibit optimal cortical perfusion donor organs. Actual data on this topic are scarce but opinions strong. To study characteristics we compared four hypothermic preservation for abdominal i.e. UW SCS, HTK, IGL-1 UW-MPS in large animal model simulating donation after circulatory death (DCD). Materials Methods...
Introduction: Serum citrulline was used as a biochemical marker to direct nutritional therapy in two phases of the post-operative course after intestinal transplantation. Methods: On predetermined day week, serum levels were monitored on weekly basis small bowel A level 13 μmol/l with normal GFR cut off guide patient's feeding regimes. Citrulline above 13μmol/l trigger start weaning TPN. Levels >18μmol/l stop TPN and achieve full enteral feeds. Patients studied separate time periods: just...
Introduction: Non-hepatic encephalopathy secondary to raised serum ammonia levels is an important consideration after systemic drainage of intestinal transplantation. Methods: We reviewed the medical records patients that underwent transplantation at a single centre. Data collected included patient demographics and transplant type. recorded time onset post operation, duration symptoms possible causes encephalopathy. Results: Since October 2008, 24 have undergone in our centre, 14 male 10...
Introduction: There is no consensus concerning the optimal technique for drainage of exocrine secretions in pancreas transplantation. We compared patients with bladder (BD) versus those enteric (ED). Methods: reviewed UK data on alone transplantation over last 10-years. The entry was between January 2004 and October 2013. Patient recipient demographics were recorded we performed multivariate univariate analysis data, Kaplan-Meier survival studies using SPSS 21.1 Results: From to 2013, 306...