A5028775419- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Muscle and Compartmental Disorders
- Hernia repair and management
- Central Venous Catheters and Hemodialysis
- Abdominal Surgery and Complications
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
- Adrenal and Paraganglionic Tumors
- Vascular Procedures and Complications
- Vascular anomalies and interventions
- Pelvic and Acetabular Injuries
- Pituitary Gland Disorders and Treatments
- Hepatitis C virus research
- Thyroid and Parathyroid Surgery
- Electrolyte and hormonal disorders
- Intraperitoneal and Appendiceal Malignancies
- Pancreatic function and diabetes
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrospinal fluid and hydrocephalus
Manchester Royal Infirmary
2016-2025
Manchester University NHS Foundation Trust
2018-2025
University of Manchester
2015-2024
Engineering and Physical Sciences Research Council
2024
Manchester Academic Health Science Centre
2015-2023
Lancashire Teaching Hospitals NHS Foundation Trust
2023
University Foundation
2020
Manchester University
2020
Metabolism and Renal Physiology
2019
Addenbrooke's Hospital
2017
We assess if ultrasound surveillance of newly-created arteriovenous fistulas (AVFs) can predict nonmaturation sufficiently reliably to justify randomized controlled trial (RCT) evaluation ultrasound-directed salvage intervention.
OBJECTIVE People with type 1 diabetes and kidney failure have an increased risk for major adverse cardiovascular events (MACE). Simultaneous pancreas transplantation (SPKT) improves survival, but the long-term MACE is uncertain. RESEARCH DESIGN AND METHODS We assessed frequency factors (defined as fatal disease nonfatal myocardial infarction or stroke) related to allograft in SPKT recipients who underwent between 2001 2015 U.K. In a subgroup, we pretransplant score MACE. RESULTS During 5...
Background Encapsulating peritoneal sclerosis (EPS) is a rare complication of prolonged dialysis (PD) exposure, characterised by thickening, calcification, and fibrosis ultimately presenting with life-threatening bowel obstruction. The presence or role calcification in the pathogenesis EPS poorly characterised. We hypothesise that significantly aberrant bone mineral metabolism patients on PD can cause which may trigger development EPS. compared temporal evolution markers during non-EPS...
Introduction Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve recommended 80% target achieving dialysis prevalent population via permanent access (as opposed to a central venous catheter). This is partly due relatively poor maturation rate newly created fistulas, as many 50% failing mature. The Surveillance Of arterioveNous fistulAe using ultRasound study will examine...
Introduction. The accuracy of intraoperative graft perfusion assessment still remains subjective, with doppler examination being the only objective adjunct. Laser speckle contrast imaging (LSCI) has been used to assess blood flow in neurosurgery and various surgical specialties. Despite its ability accurately quantify at microvascular level, it not clinically evaluated kidney/kidney-pancreas transplantation for characterization. We aimed evaluate utility LSCI identify parameters that can be...
Current risk prediction scoring systems in pancreas transplantation are limited to organ factors and specific predicting graft outcome. They do not consider recipient or inform regarding morbidity. The aim of this study was assess the utility commonly used general surgical models (P-POSSUM [Portsmouth Physiological Operative Severity Score for enUmeration Mortality morbidity], MODS [multiple dysfunction score], Charlson co-morbidity index, revised cardiac ASA [American Society...
Simultaneous pancreas and kidney transplantation (SPKT) is an effective treatment option for patients with type 1 diabetes end stage renal disease. Increasing demands organs coupled a rise in age size of adult donors has led to greater utilization pediatric donors, good outcomes. Nonetheless, there remains reticence among transplant surgeons pancreases from small despite the optimal characteristics macroscopic features younger pancreas. We report successful case SPKT donor explore aspects...
Encapsulating peritoneal sclerosis (EPS) is a rare life-threatening complication associated with dialysis (PD). EPS characterized by progressive fibrosis and of the peritoneum, formation membrane tethering loops small intestine resulting in intestinal obstruction. It very children. We present case 16-year-old adolescent boy who developed seven years after being placed on continuous ambulatory (CAPD) complicated several episodes bacterial peritonitis. The diagnosis was based clinical,...
Abstract Aim Vascular anastomosis is an important but complex skill requiring mastery by trainees across multiple specialities, with significant risk of suboptimal outcomes. Simulation allows repetitions a procedure within controlled environment, allowing training without accompanying patient risk. Current simulation courses on vascular are expensive and inaccessible to several junior trainees. A low-cost scaffold was developed for aimed assess trainee feedback utility acceptability. Method...
Abstract Aim The risk of urological complications following kidney transplantation is reduced by the intraoperative insertion ureteric stents. Transplant stent removal (TUSR) has traditionally been performed in theatre using flexible cystoscopy. Isiris® a single-use cystoscope. aim to analyse acceptability, efficacy, and cost-effectiveness Isiris®, for TUSR ward/outpatient setting. Method A retrospective analysis contemporaneously maintained database at high-volume transplant centre from...
Abstract Purpose Practise variability exists in pancreas transplantation, but the extent across EU is unknown. We surveyed transplant surgeons to assess current practices. Methods A 40-question survey was sent 84 at 17 centres 8 countries. Validity and reliability were analysed. Variability evaluated using descriptive statistics random effects modelling. Results The response rate 92% (78/84). demonstrated good validity (Cronbach’s alpha 0.82). Substantial existed donor selection criteria...