Sarah Lawman
A5029821978- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Renal Diseases and Glomerulopathies
- Vascular anomalies and interventions
- Chronic Kidney Disease and Diabetes
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Cystic Fibrosis Research Advances
- Iron Metabolism and Disorders
- Genomics and Rare Diseases
- Cardiac Arrest and Resuscitation
- Food Allergy and Anaphylaxis Research
- Anesthesia and Sedative Agents
- Psychedelics and Drug Studies
- COVID-19 Clinical Research Studies
- Erythropoietin and Anemia Treatment
- Obesity and Health Practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neurological and metabolic disorders
- Phagocytosis and Immune Regulation
- Vascular Malformations Diagnosis and Treatment
- Vasculitis and related conditions
- Acute Kidney Injury Research
University Hospitals Sussex NHS Foundation Trust
2019-2024
Royal Sussex County Hospital
2009-2020
University College London
2002-2004
North Middlesex Hospital
2002
The role of paclitaxel-coated balloons has been established in the coronary and peripheral arterial circulations with recent interest use to improve patency rates following angioplasty arteriovenous fistulas. To assess efficacy prolong survival time target lesion primary fistulas, we designed an investigator-led multi-center randomized controlled trial follow up variable for a minimum one year. Patients fistula who were undergoing clinical indication included but patients or more lesions...
Abstract Systemic lupus erythematosus is a multisystem autoimmune disease characterized by wide range of immunological abnormalities that underlie the loss tolerance. In this study we show administration atorvastatin to lupus-prone NZB/W F1 mice resulted in significant reduction serum IgG anti-dsDNA Abs and decreased proteinuria. Histologically, treatment was associated with reduced glomerular Ig deposition less injury. Disease improvement paralleled expression MHC class II on monocytes B...
Abstract Purpose Despite vaccination, many patients remain vulnerable to COVID-19 infection and poorer outcomes, because of underlying health conditions resulting in sub-optimal vaccine responses. This study aims demonstrate whether intranasal niclosamide confers additional protection against above standard preventative measures including vaccination. Methods PROTECT-V (PROphylaxis for paTiEnts at risk infecTion) is a platform trial testing multiple pre-exposure prophylactic agents patients....
The initial therapy for a stenosis in an arteriovenous fistula used haemodialysis is radiological balloon dilatation or angioplasty. benefit of angioplasty often short-lived, intervention-free survival reported to be 40–50 % at 1 year. Previous small studies and observational data suggest that paclitaxel-coated balloons may improving outcomes after fistuloplasty stenotic fistulae. We have designed multicentre, double-blind randomised controlled trial test the superiority preventing...
We assess if ultrasound surveillance of newly-created arteriovenous fistulas (AVFs) can predict nonmaturation sufficiently reliably to justify randomized controlled trial (RCT) evaluation ultrasound-directed salvage intervention.
Introduction Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve recommended 80% target achieving dialysis prevalent population via permanent access (as opposed to a central venous catheter). This is partly due relatively poor maturation rate newly created fistulas, as many 50% failing mature. The Surveillance Of arterioveNous fistulAe using ultRasound study will examine...
Abstract Background Intravenous iron is often used to treat deficiency anaemia in non-dialysis chronic kidney disease (ND-CKD), but the optimal dosing regimen remains unclear. We evaluated impact of high- versus low-dose intravenous isomaltoside on probability retreatment with iron-deficient ND-CKD patients. Methods This real-world, prospective, observational study collected data from 256 patients treated for UK. Following an initial course isomaltoside, were followed ≥12 months. Iron dose...
We present a case of 40-year-old woman with history ongoing anorexia nervosa and bulimia who has required multiple admissions to hospital for management acute kidney injury (AKI) electrolyte derangement. This is interest as recent studies have highlighted the significant prevalence disordered eating major public health implications this may have. discuss unusual finding hypercalcaemia in address investigation AKI disturbance patient bulimia.
Numerous studies have addressed the predictive value of pathology findings from Oxford Classification. Whether this influences treatment choice has not been determined. We evaluated patients with IgA nephropathy who were immunosuppressed and correlated our both clinical histological features as per This was a retrospective observational study 45 had biopsy-proven mean follow-up 2.6 years. Primary outcomes time to end-stage renal disease (ESRD) or 50% rise in serum creatinine....
Treatment of anemia in dialysis patients has been associated with increased risk vascular access thrombosis (VAT). Proactive IV irOn Therapy hemodiALysis Patients (PIVOTAL) was a clinical trial proactive compared reactive i.v. iron therapy requiring hemodialysis. We analyzed the data to determine whether randomized treatment arm, alongside other and laboratory variables, independently VAT.In PIVOTAL, 2141 adult were randomized. The type (arteriovenous fistula [AVF], arteriovenous graft...
Background Arteriovenous fistulas are considered the best option for haemodialysis provision, but as many 30% fail to mature or suffer early failure. Objective To assess feasibility of performing a randomised controlled trial that examines whether, by informing and effective salvage intervention would otherwise fail, Doppler ultrasound surveillance developing arteriovenous improves longer-term fistula patency. Design A prospective multicentre observational cohort study (the ‘SONAR’ study)....
A 28 year old man presented to the accident and emergency department with central abdominal pain that had lasted just over a day was “cramping” in nature. He bloody diarrhoea for three days, increasing frequency amount of blood. eaten chicken sandwich purchased from canteen before onset symptoms. There no history recent foreign travel or any important medical history. On examination he found be warm well perfused, his abdomen soft, mild generalised tenderness. admission full blood count,...
Elizabeth Schofield and colleagues discuss the management of patients presenting in A&E department following abuse street drugs
Mark Colbridge and colleagues discuss overdose of drugs used in depressive disorders their interactions, including the serotonin syndrome