A5012094925- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Trauma and Emergency Care Studies
- Organ Donation and Transplantation
- COVID-19 epidemiological studies
- Abdominal Trauma and Injuries
- Respiratory viral infections research
- Vascular anomalies and interventions
- Tuberculosis Research and Epidemiology
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- COVID-19 Clinical Research Studies
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Pneumonia and Respiratory Infections
- Shoulder Injury and Treatment
- Blood transfusion and management
- COVID-19 Pandemic Impacts
- Atrial Fibrillation Management and Outcomes
NHS Blood and Transplant
2013-2025
National Health Service
2023
Glan Clwyd Hospital
2021
National Health Service Wales
2020
Animal and Plant Health Agency
2019
Public Health England
2014-2019
Royal College of Emergency Medicine
2017
Royal College of General Practitioners
2017
John Radcliffe Hospital
2017
University of Surrey
2017
Importance Critical bleeding is associated with a high mortality rate in patients trauma. Hemorrhage exacerbated by complex derangement of coagulation, including an acute fibrinogen deficiency. Management replacement cryoprecipitate transfusions or concentrate, usually administered relatively late during hemorrhage. Objective To assess whether survival could be improved administering early and empirical dose to all trauma that required activation major hemorrhage protocol. Design, Setting,...
Abstract In 2008, acute hepatitis E infection was confirmed in 4 passengers returning to the United Kingdom after a world cruise. Epidemiologic investigation showed that of 789 persons who provided blood samples, 195 (25%) were seropositive, 33 (4%) had immunoglobulin [Ig] M levels consistent with recent (11 these symptomatic), and 162 (21%) IgG only, past infection. Passenger mean age 68 years. Most (426/789, 54%) female, yet most (25/33, 76%) male. Sequencing RNA from 3 case-patients...
Patients with advanced heart failure have a dismal prognosis and poor quality of life. Heart transplantation provides an effective treatment for subset these patients. This article cardiologists up-to-date information about referral transplantation, the role left ventricular assist devices prior to transplant, patient selection, waiting-list management donor availability. Timing is central importance; patients should be referred before complications (eg, cardiorenal syndrome or secondary...
BackgroundUltrasound is one of the most widely requested forms diagnostic imaging. The costs for diagnosing deep vein thrombosis (DVT) in UK are £175 million, annually. In at least 80% cases, DVT excluded. As health care provision becomes increasingly stretched, resource utilization needs to be optimized. This prospective, double-blind, test accuracy study was designed whether an artificial intelligence (AI)–guided software device (AutoDVT) could support nonradiology specialists diagnose...
Background. Ischemia time is a risk factor for mortality after heart transplantation that can be influenced by organizational factors such as transport arrangements and organ allocation. Methods. We used the United Kingdom Cardiothoracic Transplant Audit database to analyze outcome of 1491 first isolated orthotopic adult transplants performed between April 1995 March 2004. its components (transport surgical implant time) were related 30-day using multivariable logistic regression model....
Summary Optimal red cell transfusion support in myelodysplastic syndromes (MDS) has not been tested and established. The aim of this study was to demonstrate feasibility recruitment follow‐up an outpatient setting with exploratory assessment quality life (QoL) outcomes (EORTC QLQ‐C30 EQ‐5D‐5L). We randomised MDS patients standardised algorithms comparing current restrictive thresholds (80 g/l, maintain haemoglobin 85–100 g/l) liberal (105 maintaining 110–125 g/l). primary were measures...
BackgroundIn the UK, additional COVID-19 vaccine booster doses and treatments are offered to people who immunosuppressed protect against severe COVID-19, but how best choose individuals that receive these is unclear. We investigated association between seropositivity SARS-CoV-2 spike protein with demographic, disease, treatment-related characteristics after at least three vaccines in cohorts of immunosuppressed.MethodsIn a cross-sectional study using UK national disease registries, we...
Registry data can be used to examine whether there are differences between individual renal units in the proportion of dialysis patients listed for transplantation, investigate possible reasons any observed, and discover highlighting these anomalies influence practice.A cross-sectional study 12, 401 prevalent adult from 41 across England Wales was performed. The registered on deceased donor transplant waiting list determined each unit. Patient- center-specific factors that probability being...
On 22 September 2012, a novel coronavirus, very closely related to that from fatal case in Saudi Arabia three months previously, was detected previously well adult transferred intensive care London Qatar with severe respiratory illness. Strict isolation instituted. Ten days after last exposure, none of 64 close contacts had developed disease, 13 reporting mild symptoms. The coronavirus not 10 symptomatic tested.
In October 2011, two primary cases of hepatitis A virus (HAV) infection with identical HAV genotype IB strains to those seen in other outbreaks associated semi-dried tomatoes were reported England. Both had consumed tomatoes. Epidemiological investigations revealed additional different sequences who also having November, five closely related identified the Netherlands. foodborne multiple-strain outbreak is suspected.
We investigated the incidence of chronic kidney disease (CKD) in United Kingdom heart transplant population, identified risk factors for development CKD, and assessed impact CKD on subsequent survival.Data from UK Cardiothoracic Transplant Audit Renal Registry were linked 1732 adult transplantations, 1996 to 2007. Factors influencing time defined as National Kidney Foundation stage 4 or 5 preemptive transplantation, using a Cox proportional hazards model. The effects distinct stages survival...
ESBL-producing Enterobacteriaceae (ESBLPE) are increasing in prevalence worldwide and more difficult to treat than non-ESBLPE. Their the UK general population is unknown, as only previous ESBLPE faecal colonization study involved patients with diarrhoea.To estimate of CTX-M adult England 2014, investigate risk factors.A stratified random sample 58 337 registered from 16 practices within four areas were invited participate by returning faeces specimens self-completed questionnaires. Specimens...
Abstract Background Liver disease is the third leading cause of premature death in UK. Transplantation only successful treatment for end-stage liver but limited by a shortage suitable donor organs. As result, up to 20% patients on transplant waiting lists die before receiving transplant. A donated livers are not transplant, often due steatosis. Hepatic steatosis, which affects 33% UK population, strongly associated with obesity, an increasing problem potential pool. We have recently tested...
Despite control efforts, Mycobacterium bovis incidence among cattle remains high in parts of England, Wales, and Northern Ireland, attracting political public health interest potential spread from animals to humans. To determine humans identify associated factors, we conducted a retrospective cohort analysis human M. cases Ireland during 2002-2014. We identified 357 observed increased annual case numbers (from 17 35) rates. Most patients were >65 years age born the United Kingdom. The median...
Objective: Primary graft failure is the most common cause of mortality early after heart transplantation. The availability relatively low-cost short-term mechanical support devices has altered management primary but there are few data on clinical outcome. Here, we describe UK experience with Levitronix CentriMag following transplantation across multiple centres. Methods: Data for all adult transplants and used within 30 days in between November 2003 July 2008 were collected. Transplant...
During the first year of enhanced MERS coronavirus surveillance in England, 77 persons traveling from Middle East had acute respiratory illness and were tested for virus. Infection was confirmed 2 travelers with distress syndrome their contacts. Patients less severe manifestations negative.
We assess if ultrasound surveillance of newly-created arteriovenous fistulas (AVFs) can predict nonmaturation sufficiently reliably to justify randomized controlled trial (RCT) evaluation ultrasound-directed salvage intervention.
Background. Donor interventions, including medications, protocols, and medical devices administered to donors, can enhance transplantable organ quality quantity maximize transplantation success. However, there is paucity of high-quality evidence about their effectiveness, in part because ethical, practical, regulatory challenges, lack guidance conduct donor intervention randomized controlled trials (RCTs). Methods. With the vision develop authoritative for RCTs, we convened a workshop...
Background Traumatic haemorrhage is common after severe injury, leading to disability and death. Cryoprecipitate, a source of fibrinogen, may improve outcomes for patients with traumatic haemorrhage. Objective To investigate the effects early fibrinogen supplementation in form 3 pools (15 units, approximately 6 g fibrinogen) cryoprecipitate on 28-day mortality. Design A randomised, parallel-group, unblinded, multicentre, international trial economic evaluation. Patients were randomised...