A5034767089- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Organ Donation and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Organ Transplantation Techniques and Outcomes
- Sepsis Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Renal Transplantation Outcomes and Treatments
- Palliative Care and End-of-Life Issues
- Mechanical Circulatory Support Devices
- SARS-CoV-2 detection and testing
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Rate Variability and Autonomic Control
- Transplantation: Methods and Outcomes
- Advanced MRI Techniques and Applications
- Airway Management and Intubation Techniques
- Cerebrospinal fluid and hydrocephalus
Western University
2019-2025
London Health Sciences Centre
2020-2025
Lawson Health Research Institute
2020-2024
Trillium Therapeutics (Canada)
2021-2024
Translational Research in Oncology
2024
Western University of Health Sciences
2020-2023
The King's University
2022
Thrombosis and Atherosclerosis Research Institute
2021
McMaster University
2014-2021
Creative Commons
2020
This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation brain function that applies to all persons, as well recommendations for determination by circulatory criteria potential organ donors and neurologic mechanically ventilated patients regardless donation potential. is endorsed Canadian Critical Care Society, Medical Association, Association Nurses, Anesthesiologists' Neurological Sciences Federation (representing Neurosurgical Society...
Current methods of forcing end-tidal PCO2 (PETCO2) and PO2 (PETO2) rely on breath-by-breath adjustment inspired gas concentrations using feedback loop algorithms. Such servo-control mechanisms are complex because they have to anticipate compensate for the respiratory response a given inspiratory concentration basis. In this paper, we introduce low flow method prospectively target control PETCO2 PETO2 independent each other minute ventilation in spontaneously breathing humans. We used change...
Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus patients understand better the underlying pathologic processes and pathways, identify potential diagnostic/prognostic biomarkers.Blood was collected at predetermined ICU days measure plasma concentrations 162 metabolites using both direct injection-liquid chromatography-tandem mass spectrometry proton nuclear magnetic resonance.Tertiary-care academic...
Objectives: Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome coronavirus 2 virus. Patients admitted to ICU suffer from microvascular thrombosis, which may contribute mortality. Our aim was profile plasma thrombotic factors and endothelial injury markers in critically ill patients help understand their mechanisms. Design: Daily blood coagulation factor profiling with immunoassays vitro experiments on human pulmonary cells. Setting: Tertiary care academic...
The minimum duration of pulselessness required before organ donation after circulatory determination death has not been well studied.
Objectives: Coronavirus disease 2019 is caused by severe acute respiratory syndrome-coronavirus-2 infection to which there no community immunity. Patients admitted ICUs have high mortality, with only supportive therapies available. Our aim was profile plasma inflammatory analytes help understand the host response coronavirus 2019. Design: Daily blood inflammation profiling immunoassays. Setting: Tertiary care ICU and academic laboratory. Subjects: All patients suspected of being infected...
Epileptic seizures are a common presentation in patients with newly diagnosed brain arteriovenous malformations, but the pathophysiological mechanisms causing remain poorly understood. We used magnetic resonance imaging-based quantitative cerebrovascular reactivity mapping and conventional angiography to determine whether seizure-prone malformations exhibit impaired reserve or morphological angiographic features predictive of seizures. Twenty consecutive untreated were recruited (10 10...
Coronavirus disease 2019 patients admitted to the ICU have high mortality. The host response coronavirus has only been partially elucidated, and prognostic biomarkers not identified. We performed targeted proteomics on critically ill better understand their pathophysiologic mediators identify potential outcome markers.Blood was collected at predetermined days for proximity extension assays determine plasma concentrations of 1,161 proteins.Tertiary care academic laboratory.All suspected being...
Resting-state functional connectivity (rsFC) has gained popularity mainly due to its simplicity and potential for providing insights into various brain disorders. In this vein, near-infrared spectroscopy (fNIRS) is an attractive choice portability, flexibility, low cost, allowing bedside imaging of function. While promising, fNIRS suffers from non-neural signal contaminations (i.e., systemic physiological noise), which can increase correlation across channels, leading spurious rsFC networks....
Abstract Purpose To assess the effect of changes in end‐tidal partial pressure O 2 (P ET ) on cerebrovascular reactivity (CVR) estimated from blood oxygen level–dependent (BOLD) signal during cyclic CO ). Materials and Methods BOLD response to fixed step P (range = 30.4–48.8 mmHg) 100.6–444.0 was studied four healthy volunteers. Results The were 0.283 (0.188–0.379) (median, range) 0.004 (0.003–0.006)%/mmHg, respectively, whole brain; 0.438 (0.382–0.614) vs. 0.006 (0.004–0.009)%/mmHg, gray...
In-depth investigation of cerebrovascular blood flow and MR mechanisms underlying the oxygenation level dependent signal requires precise manipulation arterial partial pressure carbon dioxide oxygen, measured by their noninvasive surrogates, end-tidal values. The traditional methodology consists administering a fixed fractional concentration inspired CO(2), but this causes variable ventilatory response across subjects, resulting in different values pressures CO(2) O(2). In study, we...
Abstract Background COVID19 is caused by the SARS-CoV-2 virus and has been associated with severe inflammation leading to organ dysfunction mortality. Our aim was profile transcriptome in leukocytes from critically ill patients positive for compared those negative better understand COVID19-associated host response. For these studies, all admitted our tertiary care intensive unit (ICU) suspected of being infected SARS-CoV-2, using standardized hospital screening methodologies, had blood...
Multi-modal neuroimaging techniques have the potential to dramatically improve diagnosis of level consciousness and prognostication neurological outcome for patients with severe brain injury in intensive care unit (ICU). This protocol describes a study that will utilize functional Magnetic Resonance Imaging (fMRI), electroencephalography (EEG), Near Infrared Spectroscopy (fNIRS) measure map activity acute critically ill patients. Our goal is investigate whether these modalities can provide...
BACKGROUND. The role of humoral immunity in COVID-19 is not fully understood, owing, large part, to the complexity antibodies produced response SARS-CoV-2 infection. There a pressing need for serology tests assess patient-specific antibody and predict clinical outcome.
The study of the biology evolution has been confined to laboratories and model organisms. However, controlled laboratory conditions are unlikely variations in environments that influence selection wild populations. Thus, “fitness” for survival genetics this best carried out field matching environments. Therefore, we studied highland populations their native environments, learn how they cope with ambient hypoxia. Andeans, African highlanders Himalayans have adapted differently hostile...
ABSTRACT Introduction: Intermittent renal replacement therapy induces cardiac stunning in chronic hemodialysis and acute kidney injury (AKI) patients. In hemodialysis, recurrent contributes to heart failure death, with ultrafiltration intradialytic hypotension being the principal determinants of this injury. Continuous (CRRT), its lower rates improved hemodynamic profile, should protect against AKI. The objective study was assess whether CRRT is associated critically ill patients Methods: We...
Abstract Coronavirus disease 2019 (COVID‐19) is a systemic inflammatory condition with high mortality that may benefit from personalized medicine and high‐precision approaches. COVID‐19 patient plasma was analysed targeted proteomics of 1161 proteins. Patients were monitored Days 1 to 10 their intensive care unit (ICU) stay. Age‐ gender‐matched COVID‐19‐negative sepsis ICU patients healthy subjects examined as controls. Proteomic data resolved using both cell‐specific annotation...