A5052608762- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Hallucinations in medical conditions
- Visual perception and processing mechanisms
- Mental Health Research Topics
- Spatial Neglect and Hemispheric Dysfunction
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Hearing Loss and Rehabilitation
- Neuroscience and Music Perception
- Hearing, Cochlea, Tinnitus, Genetics
- Liver Disease and Transplantation
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Liver Disease Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Voice and Speech Disorders
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Suicide and Self-Harm Studies
- Cardiac Arrest and Resuscitation
- Parkinson's Disease Mechanisms and Treatments
- Pain Management and Treatment
Baylor College of Medicine
2018-2025
Menninger Clinic
2021-2025
Michael E. DeBakey VA Medical Center
2020-2025
The University of Sydney
2024
Royal College of Surgeons in Ireland
2024
Western University
2023
Newcastle University
2014-2021
University Hospitals Birmingham NHS Foundation Trust
2021
Queen Elizabeth Hospital
2011-2021
University of York
2015
This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation brain function that applies to all persons, as well recommendations for determination by circulatory criteria potential organ donors and neurologic mechanically ventilated patients regardless donation potential. is endorsed Canadian Critical Care Society, Medical Association, Association Nurses, Anesthesiologists' Neurological Sciences Federation (representing Neurosurgical Society...
<h3>Objective</h3> To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) primary cortex. <h3>Methods</h3> We utilized magnetic resonance spectroscopy to occipital GABA 36 participants with PD, 19 17 without complex hallucinations, together 20 healthy controls hallucinations. In addition, we acquired T1-weighted MRI, whole-brain fMRI during a task, diffusion tensor imaging. <h3>Results</h3> found lower GABA+/creatine...
We investigated for quantitative EEG (QEEG) differences between Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's (PDD) patients healthy controls, QEEG signatures of cognitive fluctuations (CFs) in DLB. analysed eyes-closed, resting state EEGs from 18 AD, 17 DLB PDD mild dementia, 21 age-matched controls. Measures included spectral power, dominant frequency (DF), prevalence (FP), temporal DF variability (DFV), within defined bands cortical regions. showed a leftward...
Executive-semantic control and action understanding appear to recruit overlapping brain regions but existing evidence from neuroimaging meta-analyses neuropsychology lacks spatial precision; we therefore manipulated difficulty feature type (visual vs. action) in a single fMRI study. Harder judgements recruited an executive-semantic network encompassing medial inferior frontal (including LIFG) posterior temporal cortex pMTG). These partially overlapped with areas involved not visual...
Misophonia is characterized by intense emotional reactions to specific sounds or visual stimuli and typically onsets during childhood. An obstacle for research clinical practice that no comprehensively evaluated measures pediatric misophonia exist. In a sample of 102 youth meeting the proposed diagnostic criteria misophonia, we child parent-proxy versions self-reported Assessment Questionnaire (MAQ; assessing broad aspects misophonia) version Amsterdam Scale (A-MISO-S; severity)....
Previous work has identified a hierarchical organization of neural oscillations that supports performance complex cognitive and perceptual tasks, can be indexed with phase-amplitude coupling (PAC) between low- high-frequency oscillations. Our aim was to employ enhanced source localization afforded by magnetoencephalography (MEG) expand on earlier reports intact auditory cortical PAC in schizophrenia investigate how may evolve over the early chronic phases illness. Individuals (n=12) (≤5...
Abstract Ketamine is an effective intervention for treatment-resistant depression (TRD), including late-in-life (LL-TRD). The proposed mechanism of antidepressant effects ketamine a glutamatergic surge, which can be measured by electroencephalogram (EEG) gamma oscillations. Yet, non-linear EEG biomarkers such as neural complexity are needed to capture broader systemic effects, represent the level organization synaptic communication, and elucidate mechanisms action treatment responders. In...
Abstract The kynurenine pathway (KP) is a strategic metabolic system that combines regulation of neuronal excitability via glutamate receptor function and neuroinflammation other KP metabolites. This has great promise in treatment depression suicidality. modulator AV-101 (4-chlorokynurenine, 4-Cl-KYN), an oral prodrug 7-chlorokynurenic acid (7-Cl-KYNA), N -methyl- d -aspartate (NMDAR) glycine site antagonist, 4-chloro-3-hydroxyanthranilic (4-Cl-3-HAA), suppressor NMDAR agonist quinolinic...
Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% cases. Integrative models their etiology posit that decline in executive control the visuo-perceptual system is primary mechanism VH generation. The role bottom-up processing manifestation this condition still not clear although visual evoked potential (VEP) differences have been associated at an earlier stage PD. Here we compared amplitude and latency pattern reversal VEPs healthy...
Background Posttraumatic stress disorder (PTSD) is associated with hyperarousal and reactivity, features consistent behavioral sensitization. In this Phase 1b, parallel-arm, randomized, double-blind, placebo-controlled trial, we tested whether the selective low-trapping N-methyl-D-aspartate receptor (NMDAR) antagonist [Lanicemine (BHV-5500)] blocks expression of Methods Twenty-four participants elevated anxiety potentiated startle (APS) moderate-to-severe PTSD symptoms received three...