A5005980231- Bayesian Methods and Mixture Models
- Statistical Methods and Bayesian Inference
- Maternal and Perinatal Health Interventions
- Reproductive Health and Contraception
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Diverse Scientific and Engineering Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cerebral Palsy and Movement Disorders
- Gastric Cancer Management and Outcomes
- Statistical Methods and Inference
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and fetal healthcare
- Healthcare Policy and Management
- Heart Rate Variability and Autonomic Control
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Hereditary Neurological Disorders
- Optical Imaging and Spectroscopy Techniques
Universidade Estadual de Campinas (UNICAMP)
2014-2022
Medical Research Council
2012
Pennsylvania State University
2009
The <b>mixtools</b> package for <code>R</code> provides a set of functions analyzing variety finite mixture models. These include both traditional methods, such as EM algorithms univariate and multivariate normal mixtures, newer methods that reflect some recent research in In the latter category, estimating parameters wide range different mixture-of-regression contexts, multinomial mixtures those arising from discretizing continuous data, nonparametric situations where component densities...
Abstract We propose an algorithm for nonparametric estimation finite mixtures of multivariate random vectors that strongly resembles a true EM algorithm. The are assumed to have independent coordinates conditional upon knowing from which mixture component they come, but otherwise their density functions completely unspecified. Sometimes, the may be partially specified by Euclidean parameters, case we call semiparametric. Our is much more flexible and easily applicable than existing...
Resting-state functional connectivity (rsFC) has gained popularity mainly due to its simplicity and potential for providing insights into various brain disorders. In this vein, near-infrared spectroscopy (fNIRS) is an attractive choice portability, flexibility, low cost, allowing bedside imaging of function. While promising, fNIRS suffers from non-neural signal contaminations (i.e., systemic physiological noise), which can increase correlation across channels, leading spurious rsFC networks....
Abstract Background SARS-CoV-2, the virus that causes COVID-19, enters cells through a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), protein highly expressed in lungs. The putative viral-induced inhibition of ACE2 could result defective degradation bradykinin, potent inflammatory substance. We hypothesize increased bradykinin lungs is an important driving development pneumonia and respiratory failure COVID-19. Methods This phase II, single-center, three-armed...
Abstract Background Hereditary spastic paraplegia presents spasticity as the main clinical manifestation, reducing gait quality and producing incapacity. Management with botulinum toxin type A (BoNT‐A) is not well elucidated. The objective of current study was to evaluate efficacy safety BoNT‐A in patients hereditary paraplegias. Methods This a double‐blind, randomized, placebo‐controlled crossover trial. Each participant randomly assigned receive 1 injection session either (100 IU/2 mL...
Health economic evaluations require estimates of expected survival from patients receiving different interventions, often over a lifetime. However, data on the interest are typically only available for much shorter follow-up time, randomised trials or cohorts. Previous work showed how to use general population mortality improve extrapolations short-term data, assuming constant additive multiplicative effect hazards all-cause study relative population. A more plausible assumption may be...
O aborto medicamentoso ou farmacológico tem demonstrado ser um meio eficaz para a interrupção da gravidez. Entretanto, o treinamento de provedores no uso do misoprostol sido limitado. presente artigo como objetivo identificar grau conhecimento dos médicos residentes em Ginecologia e Obstetrícia sobre medicamentoso. Realizou-se estudo transversal multicêntrico com regularmente inscritos programa residência vinte hospitais ensino. Foi utilizado questionário autorresposta. As respostas corretas...