Thyago A. Nunes
A5070931888- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Blood disorders and treatments
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Eosinophilic Esophagitis
- Erythrocyte Function and Pathophysiology
- Food Allergy and Anaphylaxis Research
- Blood groups and transfusion
- Biomarkers in Disease Mechanisms
- Chronic Lymphocytic Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes and associated disorders
- Immune responses and vaccinations
- Contact Dermatitis and Allergies
- COVID-19 Impact on Reproduction
Universidade Estadual de Campinas (UNICAMP)
2020-2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such lymphocytopenia cytokine storm, which are associated with severity predict mortality. mechanism by infection result in immune system dysfunction still not fully understood. Here, we show that human CD4+ T helper cells, but CD8+ present blood...
COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone develop the form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines onset cytokine storm found patients unknown. Monocytes/macrophages most enriched immune cell types lungs appear have a central role pathogenicity disease. These cells adapt their metabolism upon become highly glycolytic, which facilitates...
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is major pathological finding autopsies explaining O2 diffusion failure and hypoxemia. Only dexamethasone has been shown reduce mortality cases, further supporting role for inflammation severity. SARS-CoV-2 enters cells employing angiotensin-converting enzyme 2 (ACE2) as receptor, which highly expressed alveolar cells. ACE2 one of the...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs angiotensin-converting enzyme (ACE2) as its receptor for cell entrance, and studies have suggested that upon viral binding, ACE2 catalytic activity could be inhibited; therefore, impacting the regulation of renin-angiotensin-aldosterone system (RAAS). To date, only few evaluated impact SARS-CoV-2 infection on blood levels components RAAS. The objective this study was to determine ACE, ACE2, angiotensin-II, angiotensin...
Coagulation activation is a prominent feature of severe acute respiratory syndrome coronavirus 2 (COVID-19) infection. Activation the contact system and intrinsic pathway has increasingly been implicated in prothrombotic state observed both sterile infectious inflammatory conditions. We therefore sought to assess individuals with COVID-19 Baseline plasma levels protease:serpin complexes indicative pathways were measured samples from inpatients healthy individuals. Cleaved kininogen,...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak tract disease known as disease-2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such lymphocytopenia cytokine storm, which are associated with severity predict mortality 1,2 . mechanism by infection result in immune system dysfunction still not fully understood. Here we show that human CD4 + T helper cells, but CD8 present blood...
Abstract Background SARS-CoV-2, the virus that causes COVID-19, enters cells through a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), protein highly expressed in lungs. The putative viral-induced inhibition of ACE2 could result defective degradation bradykinin, potent inflammatory substance. We hypothesize increased bradykinin lungs is an important driving development pneumonia and respiratory failure COVID-19. Methods This phase II, single-center, three-armed...
Abstract Background Common variable immunodeficiency is the most prevalent symptomatic primary in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious diseases and recent reports have provided data supporting increased susceptibility of these severe SARS-CoV-2 infections. In this context, infusion COVID-19 convalescent plasma could represent effective therapeutic strategy. Case presentation 25-year old woman diagnosed with common 2013,...
Abstract Coronavirus disease-19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is major pathological finding autopsies explaining O 2 diffusion failure and hypoxemia. Only dexamethasone has been shown reduce mortality cases, further supporting role for inflammation disease severity. SARS-CoV-2 enters cells employing angiotensin converting enzyme (ACE2) as receptor, which highly expressed alveolar cells. ACE2 one of...
As imunodeficiências secundárias podem ser uma consequência de neoplasias, infecções ou tratamentos imunossupressores.O rituximabe (RTX) é um anticorpo anti-CD20 que depleta os linfócitos B e pode induzir hipogamaglobulinemia sintomática.Aqui, relatamos três casos sintomática associada ao uso RTX.Na primeira paciente com artrite reumatoide, o RTX induziu a baixos níveis imunoglobulinas associadas vias aéreas repetição.Após suspensão do RTX, houve normalização da resposta imune humoral.Os...