A5042998036- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Liver Disease and Transplantation
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion channel regulation and function
- Liver physiology and pathology
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Spinal Cord Injury Research
- Hepatitis C virus research
- Cerebrospinal fluid and hydrocephalus
- Liver Diseases and Immunity
- Acute Ischemic Stroke Management
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
Sir Charles Gairdner Hospital
2015-2025
The University of Western Australia
2015-2025
University of Kansas
2025
Queen's University
2020
University of Bristol
2019
University of California, San Diego
2019
Bristol-Myers Squibb (United States)
2018
Icahn School of Medicine at Mount Sinai
2014-2017
The University of Texas MD Anderson Cancer Center
2015
Fremantle Hospital
2014
Background and Purpose —This study reports the surgical results in those patients who underwent carotid endarterectomy North American Symptomatic Carotid Endarterectomy Trial (NASCET). Methods —The rates of perioperative stroke death at 30 days final assessment severity 90 were calculated. Regression modeling was used to identify variables that increased or decreased risk. Nonoutcome complications summarized. The durability examined. Results —In 1415 there 92 outcome events, for an overall...
<h3>Background</h3> HHT is an autosomal dominant disease with estimated prevalence of at least 1/5000 which can frequently be complicated by the presence clinically significant arteriovenous malformations in brain, lung, gastrointestinal tract and liver. under-diagnosed families may unaware available screening treatment, leading to unnecessary stroke life-threatening hemorrhage children adults. <h3>Objective</h3> The goal this international guidelines process was develop evidence-informed...
The natural history of aggressive (Borden 2 and 3) cranial dural arteriovenous fistulas (DAVFs) is not well described. Reported annual mortality hemorrhage rates vary widely range up to 20% per year. A consecutive single-center cohort 236 cases that presented with a DAVF between June 1984 May 2001 was reviewed for the consequences long-term persistent cortical venous reflux (CVR).A group 118 DAVFs selected presence CVR. All patients were offered treatment aimed at disconnection Patients who...
Background and Purpose— Patients harboring brain arteriovenous malformations (bAVMs) are at a lifelong risk for hemorrhagic strokes, but the natural history is poorly understood. We examined impact of demographic angiographic features on likelihood future hemorrhage. Methods— A prospectively accrued database bAVM patients maintained Toronto Western Hospital was analyzed; 678 consecutive, enrolled were followed 1931.7 patient-years. The rate hemorrhage over long-term follow-up recorded....
✓ A number of classification schemes for intracranial dural arteriovenous fistulas (AVFs) have been published that claim to predict which lesions will present in a benign or aggressive fashion based on radiological anatomy. We tested the validity two proposed first time large single-institution study. series 102 AVFs 98 patients assessed at single institution was analyzed. All were classified according grading scales: more descriptive schema Cognard, et al. (Cognard) and recently by Borden,...
This study was conducted to determine the safety and efficacy of multilevel anterior cervical corpectomy stabilization using fibular allograft in patients with myelopathy. Thirty-six underwent this procedure for myelopathy caused by spondylosis (20 patients), ossified posterior longitudinal ligament (four trauma (one patient), or a combination lesions (11 patients). The mean age (+/- standard deviation) 58 +/- 10 years 30 were men. duration symptoms before surgery 6 months 11 had undergone...
Background and Purpose — In the early 1980s, it was demonstrated that surgical intradural division of shunting vein to medullary venous plexus cures a spinal dural arteriovenous fistula (DAVF) at low morbidity. There is, however, growing literature support endovascular therapy. Methods The clinical features 49 consecutive patients with DAVF treated single institution between 1986 2001 were studied (mean age, 63 years; range, 28 78 80% male). When possible, embolization offered as initial...
Background and Purpose — The correlation between features present in brain arteriovenous malformations (AVMs) such as size, location, angioarchitecture at presentation with subsequent risk of hemorrhage may be valuable predicting the behavior AVMs therefore guiding management. Methods We prospectively followed up 390 patients University Toronto Vascular Malformation Study Group. Location, details, blood supply, clinical were recorded baseline. Intracranial hemorrhages during follow-up...
Background and Purpose — Associations between clinical presentation of brain arteriovenous malformations (AVMs) their angioarchitecture have been described. This study aims to identify significant factors related the initial hemorrhagic event through multivariate statistical methodology. Methods The authors studied 390 consecutive patients with AVMs at University Toronto Vascular Malformation Study Group. Angiographic features present that time, such as location, size, blood supply, were...
Chronic shunt-dependent hydrocephalus is a recognized complication of aneurysmal subarachnoid hemorrhage. While its incidence and risk factors have been well described, the long-term performance shunts in this setting has not widely reported.Using administrative databases, authors derived retrospective cohort patients undergoing treatment ruptured aneurysm Ontario, Canada, between 1995 2005. The determined analyzed putative factors. Mortality rates indicators morbidity were recorded....
The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer (PCa) randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. To determine report outcomes according treatment received in randomised choice cohorts. This study focuses on secondary care. Men clinically at one nine UK centres were invited participate the comparing AM, Two cohorts included 1643 who agreed be randomised; 997 declined randomisation chose...
Ischemia results in increased phosphorylation of NMDA receptors. To investigate the possible role lipid rafts this increase, and post-synaptic densities (PSDs) were isolated by extraction rat brain synaptosomes with Triton X-100 followed sucrose density gradient centrifugation. Lipid accounted for majority PSD-95, whereas SAP102 was predominantly located PSDs. Between 50 60% receptors associated rafts. Greater than 85-90% Src Fyn present rafts, Pyk2 mainly PSDs from animals subjected to 15...
Posterior fossa brain arteriovenous malformations (PFbAVMs) are rare lesions. Management is complicated by eloquence of adjacent neurological structures, multimodality treatment often necessary, and obliteration not always possible. We describe a 15-year experience in the management posterior AVMs with focus on clinical outcome.From 1989 to 2004, prospectively collected information 106 patients diagnosis PFbAVMs was obtained. Clinical angioarchitectural characteristics, options complications...
Epileptic seizures are a common presentation in patients with newly diagnosed brain arteriovenous malformations, but the pathophysiological mechanisms causing remain poorly understood. We used magnetic resonance imaging-based quantitative cerebrovascular reactivity mapping and conventional angiography to determine whether seizure-prone malformations exhibit impaired reserve or morphological angiographic features predictive of seizures. Twenty consecutive untreated were recruited (10 10...
Determination of cirrhosis in nonalcoholic fatty liver disease (NAFLD) is important as it alters prognosis and management. We aimed to examine whether was diagnosed incidentally or intentionally patients with NAFLD. reviewed 100 NAFLD determine mode diagnosis (incidental by intent), severity at diagnosis, diagnostician, previous clinical imaging laboratory evidence unrecognized cirrhosis. The majority (66/100) were incidentally, the these (74%) simultaneously. Those incidental diagnoses had...
Summary Background Reports of DILI due to herbal and dietary supplements have been increasing over time. Aims To characterise clinical, laboratory histopathological phenotypes outcomes drug‐induced liver injury (DILI) anabolic‐androgenic steroids (AAS), selective androgen receptor modulators (SARMs), bodybuilding (BBS) in Australia. Methods Retrospective case series. Patients presented nine Australian tertiary hospitals, 2017–2023. was defined biochemically patients were included if their...
Activation of the N-methyl-D-aspartate (NMDA) receptor has been implicated in events leading to ischemia-induced neuronal cell death. Recent studies have indicated that properties NMDA channel may be regulated by tyrosine phosphorylation. We therefore examined effects transient cerebral ischemia on phosphorylation subunits NR2A and NR2B different regions rat brain. Transient (15 min) global was produced four-vessel occlusion procedure. The immunoprecipitation with anti-tyrosine phosphate...
Object. A single-institution series of 119 consecutive patients with a dural arteriovenous fistula (DAVF) and cortical venous reflux was reviewed to assess the overall clinical outcome multidisciplinary management after long-term follow up. The selective disconnection compared obliteration entire DAVF evaluated. Methods. Dural fistulas in this were diagnosed between 1984 2001, treatment instituted 102 them. adequately treated that control group consisting those persistent data found...