A5061090915- Heart Rate Variability and Autonomic Control
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Esophageal and GI Pathology
- Thermoregulation and physiological responses
- Esophageal Cancer Research and Treatment
- Pleural and Pulmonary Diseases
- Non-Invasive Vital Sign Monitoring
- Family and Patient Care in Intensive Care Units
- Cardiovascular and exercise physiology
- Climate Change and Health Impacts
- Neonatal and fetal brain pathology
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Palliative Care and End-of-Life Issues
- Gastric Cancer Management and Outcomes
- Healthcare Technology and Patient Monitoring
- Immune Response and Inflammation
- Frailty in Older Adults
- Innovations in Medical Education
University of Ottawa
2016-2025
Ottawa Hospital
2016-2025
Ottawa Hospital Research Institute
2015-2024
Institute of Electrical and Electronics Engineers
2024
Health Net
2024
Ottawa University
2019-2024
Los Alamitos Medical Center
2024
McGill University
1997-2023
Canadian Association of Thoracic Surgeons
2020-2023
English Heritage
2023
Background Early diagnosis of sepsis enables timely resuscitation and antibiotics prevents subsequent morbidity mortality. Clinical approaches relying on point-in-time analysis vital signs or lab values are often insensitive, non-specific late diagnostic markers sepsis. Exploring otherwise hidden information within intervals-in-time, heart rate variability (HRV) has been documented to be both altered in the presence sepsis, correlated with its severity. We hypothesized that by continuously...
Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy intensive care unit (ICU) shown mixed results respect to risk death and organ dysfunction.
KEY POINTS Many physicians may not be aware that the term "sepsis" has undergone a change in definition is important for research and our understanding of its management. A joint task force Society Critical Care Medicine European Intensive
We examined whether older individuals experience greater levels of hyperthermia and cardiovascular strain during an extreme heat exposure compared to young adults. During a 3-hour (44°C, 30% relative humidity), we body storage, core temperature (rectal, visceral) (heart rate, cardiac output, mean arterial pressure, limb blood flow) responses adults (n = 30, 19-28 years) against those 55-73 years). Direct calorimetry measured whole-body evaporative dry exchange. Body storage was calculated as...
The minimum duration of pulselessness required before organ donation after circulatory determination death has not been well studied.
During the coronavirus disease 2019 (COVID-19) pandemic, delaying lifesaving cancer surgeries must be done with extreme caution and thoughtfulness. Modelling indicates that delays in high-risk beyond 6 weeks could affect long-term outcomes for thousands of Canadians. Consequently, it is possible postponing surgery without consideration its implications cost more lives than can saved by diverting all surgical resources to COVID-19. This article provides general guidance on supporting curative...
Critical illness requiring invasive mechanical ventilation can precipitate important functional disability, contributing to multidimensional morbidity following admission an intensive care unit (ICU). Early in-bed cycle ergometry added usual physiotherapy may mitigate ICU-acquired physical function impairment.
Objective To evaluate the in vivo effects of hypertonic saline (HTS) resuscitation on interactions endothelial cells (ECs) and polymorphonuclear neutrophils (PMNs) vascular permeability after hemorrhagic shock. Summary Background Data The PMN has been implicated pathogenesis EC damage organ injury following Compared to Ringer's lactate (RL), HTS diminishes adhesion molecule expression sequestration PMNs. Methods In a murine model shock (50 mmHg for 45 minutes followed by resuscitation) using...
This article offers a new definition of life as “self-contained, self-regulating, self-organizing, self-reproducing, interconnected, open thermodynamic network component parts which performs work, existing in complex regime combines stability and adaptability the phase transition between order chaos, plant, animal, fungus, or microbe.” Open networks, create maintain are used by all organisms to perform import energy from export entropy into environment. Intra- extracellular interconnected...