A5016299027- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Sleep and related disorders
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Radiology practices and education
- Cardiac Arrest and Resuscitation
- Global Cancer Incidence and Screening
- Hemodynamic Monitoring and Therapy
- Long-Term Effects of COVID-19
- Palliative Care and End-of-Life Issues
- Transplantation: Methods and Outcomes
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Frailty in Older Adults
- Radiation Dose and Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Polyomavirus and related diseases
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
University of Maryland, Baltimore
2016-2025
University of Maryland Medical Center
2013-2024
University of Maryland Medical Center Midtown Campus
2018-2024
Centre Hospitalier Universitaire de Sherbrooke
2024
Niagara Health System
2024
Pulmonary and Critical Care Associates
2015-2023
RELX Group (Netherlands)
2023
Birmingham VA Medical Center
2023
VA Maryland Health Care System
2022
Baltimore VA Medical Center
2022
Critical illness requiring invasive mechanical ventilation can precipitate important functional disability, contributing to multidimensional morbidity following admission an intensive care unit (ICU). Early in-bed cycle ergometry added usual physiotherapy may mitigate ICU-acquired physical function impairment.
Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether NEU1-selective inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-N-acetylneuraminic acid (C9-BA-DANA), inhibits one or more established NEU1-mediated bioactivities cells. IC50 values of C9-BA-DANA for total activity epithelia, fibroblasts to be 3.74 µM, 13.0 µM 4.82 respectively. In dose-dependently inhibited...
Airway epithelia express sialylated receptors that recognize exogenous danger signals. Regulation of receptor responsiveness to these signals remains incompletely defined. Here, we explore the mechanisms through which human sialidase, neuraminidase-1 (NEU1), promotes interaction between sialoprotein, mucin 1 (MUC1), and opportunistic pathogen, Pseudomonas aeruginosa. P. aeruginosa flagellin engaged MUC1 ectodomain (ED), increasing NEU1 association with MUC1. The stimulus increased MUC1-ED...
Background: Previous studies have shown that needle gauge size has no significant impact on diagnostic yield during endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA). Our objective was to determine whether cell blocks obtained via the new Flex 19G EBUS-TBNA would contain more cellular material based area compared with those from a 21G needle. Methods: A prospective analysis of patients undergoing at our institutions performed. Sampling same lesion(s) both and needles...
To evaluate whether a multicomponent intervention, particularly increasing staff, can achieve reductions in patient mortality an already high-intensity, Leapfrog-compliant medical intensive care unit.Retrospective, observational study.Medical unit of tertiary care, academic center.A total 1,263 patients admitted between April 19, 2004 and 18, 2006 (before the organizational change) were compared with 2,424 September 5, 4, 2008.A intervention including physical move from 10-bed to 29-bed...
Chronic rejection, manifesting as bronchiolitis obliterans, is the leading cause of death in lung transplant recipients. In our previously reported double-blinded, placebo-controlled trial comparing inhaled cyclosporine (ACsA) to aerosol placebo, rate bronchiolitis-free survival improved. However, an independent analysis pulmonary function, a secondary endpoint trial, was not performed. We sought determine effect ACsA, addition systemic immunosuppression, on function.From 1998-2001, 58...
Introduction: Remotely tele-mentored ultrasound (RTMUS) involves the real-time guidance of US-naïve providers as they perform point-of-care (POCUS) by remotely located, US-proficient via telemedicine. The concordance between RTMUS and POCUS in evaluation critically ill patients has not been reported. This study sought to evaluate for cardiopulmonary acute respiratory insufficiency and/or shock. Methods: Ultrasound-naÏve nurses performed on patients. Concordance (performed critical care...