Jennifer Tsang
A5046674376- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Health Sciences Research and Education
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Clinical Nutrition and Gastroenterology
- Health and Medical Research Impacts
- COVID-19 and Mental Health
- COVID-19 Impact on Reproduction
- Airway Management and Intubation Techniques
- Clostridium difficile and Clostridium perfringens research
- Research Data Management Practices
- Disaster Response and Management
- Primary Care and Health Outcomes
- Patient Dignity and Privacy
META Group
2025
Analysis Group (United States)
2025
Niagara Health System
2015-2024
McMaster University
2013-2024
Regional Municipality of Niagara
2016-2024
Sunnybrook Health Science Centre
2010-2024
University of Toronto
2008-2024
Impact
2024
Centre hospitalier universitaire de Québec
2024
Western University
2024
Abstract The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies suggested that the antibody content could influence patient outcomes. We conducted an open-label, trial adults with COVID-19 receiving oxygen within 12 d respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml or standard care. composite primary outcome was intubation death by 30...
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
<h3>Importance</h3> Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported. <h3>Objective</h3> To evaluate effect of<i>Lactobacillus rhamnosus</i>GG on preventing VAP, additional infections,...
The efficacy and safety of prone positioning is unclear in nonintubated patients with acute hypoxemia COVID-19.To evaluate the adverse events adult COVID-19.Pragmatic, unblinded randomized clinical trial conducted at 21 hospitals Canada, Kuwait, Saudi Arabia, US. Eligible COVID-19 were not intubated required oxygen (≥40%) or noninvasive ventilation. A total 400 enrolled between May 19, 2020, 18, 2021, final follow-up was completed July 2021.Patients to awake (n = 205) usual care without...
Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear.
<h3>Background:</h3> Clinical data on patients admitted to hospital with coronavirus disease 2019 (COVID-19) provide clinicians and public health officials information guide practice policy. The aims of this study were describe COVID-19 intensive care, investigate predictors outcome characterize severe acute respiratory infection. <h3>Methods:</h3> This observational cohort used Canadian from 32 selected hospitals included in a global multisite between Jan. 24 July 7, 2020. Adult pediatric...
Blood collection for laboratory testing in intensive care unit (ICU) patients is a modifiable contributor to anemia and red blood cell (RBC) transfusion. Most withdrawn not required analysis discarded.
Critical illness requiring invasive mechanical ventilation can precipitate important functional disability, contributing to multidimensional morbidity following admission an intensive care unit (ICU). Early in-bed cycle ergometry added usual physiotherapy may mitigate ICU-acquired physical function impairment.
Journal Article Should I Brag? Nature and Impact of Positive Boastful Disclosures for Women Men Get access Lynn Carol Miller, Miller Assistant Professor 1Communication Arts Sciences Psychology at the University Southern California Search other works by this author on: Oxford Academic Google Scholar Linda Lee Cooke, Cooke Graduate Student 2Psychology Claremont School Jennifer Tsang, Tsang 3Psychology Michigan State Faith Morgan 4At time research was conducted, a doctoral candidate in...
Recent evidence from the fields of microbiology and immunology, as well a small number human sepsis studies, suggest that epigenetic regulation may play central role in pathogenesis sepsis. The term "epigenetics" refers to regulatory mechanisms control gene expression but are not related changes DNA sequence. These include methylation, histone modifications, transcription via non-coding RNAs. Epigenetic occurring response external stressors, lead expression, thus lie at intersection between...
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment uncertain.
Effective and rapid bacterial clearance is a fundamental determinant of outcomes in sepsis. DJ-1 well-established reactive oxygen species (ROS) scavenger.Because cellular ROS status pivotal to inflammation killing, we determined the role sepsis.We used cell murine models with gain- loss-of-function experiments, plasma, cells from patients sepsis.Stimulation bone marrow-derived macrophages (BMMs) endotoxin resulted increased mRNA protein expression. Cellular mitochondrial was DJ-1-deficient...
Epigenetic alterations are an important regulator of gene expression in health and disease; however, epigenetic data sepsis lacking. To demonstrate proof concept estimate effect size, we performed the first epigenome-wide methylation analysis whole blood DNA samples from a cohort septic nonseptic critically ill patients.
Risk prediction scores are important tools to support clinical decision-making for patients with coronavirus disease (COVID-19). The objective of this paper was validate the 4C mortality score, originally developed in United Kingdom, a Canadian population, and examine its performance over time. We conducted an external validation study within registry COVID-19 positive hospital admissions Kitchener-Waterloo Hamilton regions southern Ontario between March 4, 2020 June 13, 2021. examined...
Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during emerging disease outbreaks. A study ICU HCW from France revealed symptoms anxiety and depression in 50.4% 30.4% the peak first wave pandemic. The level COVID-19 exposure these was very high. In Canada, experienced variable to pandemic, with some hospitals seeing large numbers patients while others saw few or none. this we examined relationship between Canadian HCW. We conducted a cross-sectional...
Abstract Background Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease resistance. We compared disruption ARG following 7 or 14 days of antibiotics for treatment bacteremia in sub-study the BALANCE randomized controlled trial (RCT). Methods The RCT enrolled 3631 participants with 1:1 to receive antibiotics. Rectal swabs were collected from 131 analyzed metagenomic sequencing characterize ARGs....
Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed wellness coping during the COVID-19 pandemic.
KEY POINTS The traditional setting of health research is academic centres.[1][1],[2][2] However, Canadian care could benefit from conducted and started in centres where most the population receives with substantial potential to conduct research: community hospitals.[3][3]
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) down-regulates angiotensin-converting enzyme 2, potentially increasing angiotensin II. We hypothesized that losartan compared to usual care decreases mortality and is safe in patients hospitalized with disease 2019 (COVID-19). aimed evaluate the effect of versus on 28-day for COVID-19. Methods Eligibility criteria included adults admitted Exclusion were hypotension, hyperkalemia, kidney injury, use receptor...