Marina I. Salvadori
A5062111079- Renal Transplantation Outcomes and Treatments
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- Viral gastroenteritis research and epidemiology
- Organ Donation and Transplantation
- Influenza Virus Research Studies
- Cervical Cancer and HPV Research
- Obesity, Physical Activity, Diet
- Metabolism and Genetic Disorders
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Dialysis and Renal Disease Management
- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Neurological Complications and Syndromes
- Head and Neck Cancer Studies
- Antimicrobial Resistance in Staphylococcus
McGill University
2022-2025
Public Health Agency of Canada
2012-2025
University of Ottawa
2024
Ottawa Public Health
2024
Hospital for Sick Children
2021-2024
SickKids Foundation
2021-2024
University of Toronto
2021-2024
Great Ormond Street Hospital
2021-2024
University College London
2021-2024
Public Health Ontario
2024
BackgroundWorld Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a in patients hospitalized with coronavirus disease 2019 (Covid-19).MethodsWe randomly assigned inpatients Covid-19 equally between one the trial drug regimens that was locally available open control (up to five options, active local standard care). The intention-to-treat primary analyses examined in-hospital...
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
Little is known about the risk factors for, and of, developing post-COVID-19 conditions (PCCs) among children.To estimate proportion of SARS-CoV-2-positive children with PCCs 90 days after a positive test result, to compare this SARS-CoV-2-negative children, assess associated PCCs.This prospective cohort study, conducted in 36 emergency departments (EDs) 8 countries between March 7, 2020, January 20, 2021, included 1884 who completed 90-day follow-up; 1686 these were frequency matched by...
Summary Background and objectives The effect of increased fluid intake on kidney function is unclear. This study evaluates the relationship between urine volume renal decline over 6 years in a large community-based cohort. Design, setting, participants, & measurements prospective cohort was undertaken Canada from 2002 to 2008. We obtained 24-hour samples adult participants with an estimated GFR (eGFR) ≥60ml/min per 1.73 m 2 at entry. Percentage annual change eGFR baseline categorized as...
OBJECTIVE. Childhood overweight and obesity may result in premature onset of cardiovascular risk factors such as hypertension. Rural populations North America be at increased for overweight. We evaluated whether were associated with prehypertension hypertension a well-characterized population children rural Canada. METHODS. The study this cross-sectional was composed (aged 4–17 years) who participants the Walkerton Health Study (Canada) 2004. Prehypertension defined on basis percentiles from...
<h3>Background:</h3> Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with Canada and identify risk more disease. <h3>Methods:</h3> conducted a national prospective study using the infrastructure Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted microbiologically confirmed reported from Apr. 8 Dec. 31 2020, through weekly online questionnaires...
<h3>Importance</h3> Severe outcomes among youths with SARS-CoV-2 infections are poorly characterized. <h3>Objective</h3> To estimate the proportion of children severe within 14 days testing positive for in an emergency department (ED). <h3>Design, Setting, and Participants</h3> This prospective cohort study 14-day follow-up enrolled participants between March 2020 June 2021. Participants were aged younger than 18 years who tested infection at one 41 EDs across 10 countries including...
Importance Clinical manifestations of SARS-CoV-2 variants have not been systematically compared in children. Objective To compare symptoms, emergency department (ED) chest radiography, treatments, and outcomes among children with different variants. Design, Setting, Participants This multicenter cohort study was performed at 14 Canadian pediatric EDs. included adolescents younger than 18 years (hereinafter referred to as children) tested for infection an ED between August 4, 2020, February...
Acute bacterial gastroenteritis is associated with subsequent post-infectious irritable bowel syndrome (PI-IBS) in adults. Less known about this relationship children. In May 2000, contamination of municipal water by Escherichia coli 0157:H7 and Campylobacter species caused a large outbreak acute Walkerton, Ontario. We assessed association among cohort children enrolled the Walkerton Health Study (WHS).WHS participants who were under age 16 at time but reached during 8-year study follow-up...
Sexually transmitted infection with the human papillomavirus (hpv) is responsible for a significant burden of cancers involving cervix, anogenital tract, and oropharynx. Studies in United States Europe have demonstrated an alarming increase frequency hpv-positive oropharyngeal cancer, but same direct evidence does not exist Canada.Using London Health Sciences Centre pathology database, we identified tonsillar diagnosed between 1993 2011. Real-time polymerase chain reaction was then used on...
<b>Objectives</b> To evaluate the risk for hypertension, renal impairment, and cardiovascular disease within eight years of gastroenteritis from drinking water contaminated with <i>Escherichia coli</i> O157:H7 <i>Campylobacter</i>. <b>Design</b> A prospective cohort study. <b>Setting </b>Walkerton, Ontario, Canada. <b>Participants</b> 1977 adult participants in Walkerton Health Study recruited between 2002 2005 after an outbreak May 2000, when a municipal system was contaminated, no...
Background An epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has been reported worldwide largely due to oral infection with HPV type-16, which is responsible for approximately 90% HPV-positive cases. The purpose this study was determine the rate in Southwestern Ontario, Canada. Methods A retrospective search identified ninety-five patients diagnosed OPSCC. Pre-treatment biopsy specimens were tested p16 expression using immunohistochemistry and...
Rapid kidney function decline (RKFD) predicts cardiovascular morbidity and mortality, but serial assessment of estimated GFR (eGFR) is not cost-effective for the general population. Here, we evaluated predictive value albuminuria three thresholds dipstick proteinuria to identify RKFD in 2,574 participants a community-based prospective cohort study with median 7 years follow-up. Median change eGFR was -0.78 ml/min per 1.73 m(2) year; 8.5% experiencing RKFD, defined as >5% annual from...
SUMMARY To determine whether drinking water contaminated with antimicrobial-resistant E. coli is associated the carriage of resistant , selected households sending samples to Ontario and Alberta laboratories in 2005–2006 were asked participate a cross-sectional study. Household members aged ⩾12 years complete questionnaire submit rectal swab. In 878 individuals, 41% carried strain 28% multidrug-resistant strain. The risk was 1·26 times higher for users . Other factors included international...
Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors disease among hospitalized in Canada.We conducted a national prospective on microbiologically confirmed SARS-CoV-2 infection via Canadian Paediatric Surveillance Program (CPSP) April 2020-May 2021. Cases were...
Background: Mpox is a viral illness related to smallpox.It can cause flu-like symptoms and rash, in severe cases, lead hospitalization or death.The Imvamune® vaccine offers protection against mpox.Consistent with global trends, mpox cases Canada have been reported primarily among men who sex (MSM), sexual contact as the predominantly mode of transmission.While incidence has significantly declined since fall 2022, remains an important public health concern potential for future resurgence....