A5088699247- Hemophilia Treatment and Research
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Menstrual Health and Disorders
- Platelet Disorders and Treatments
- Abdominal Trauma and Injuries
- Uterine Myomas and Treatments
- Neutropenia and Cancer Infections
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Diabetes Management and Research
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Parvovirus B19 Infection Studies
- Urological Disorders and Treatments
- Kawasaki Disease and Coronary Complications
- Endometriosis Research and Treatment
- Congenital Diaphragmatic Hernia Studies
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Dietetics, Nutrition, and Education
- Radiation Dose and Imaging
- Syphilis Diagnosis and Treatment
Dalhousie University
2011-2024
Izaak Walton Killam Health Centre
2012-2024
University of Toronto
2004-2021
Hospital for Sick Children
2004-2021
SickKids Foundation
2004-2021
University of Alberta
2021
Children's Hospital of Eastern Ontario
2021
Université Laval
2021
Centre Hospitalier Universitaire Sainte-Justine
2021
Centre Hospitalier Universitaire de Sherbrooke
2021
<h3>Background:</h3> Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with Canada and identify risk more disease. <h3>Methods:</h3> conducted a national prospective study using the infrastructure Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted microbiologically confirmed reported from Apr. 8 Dec. 31 2020, through weekly online questionnaires...
Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors disease among hospitalized in Canada.We conducted a national prospective on microbiologically confirmed SARS-CoV-2 infection via Canadian Paediatric Surveillance Program (CPSP) April 2020-May 2021. Cases were...
Abstract To document the clinical activity of imatinib mesyalte in a child with dermatofibrosarcoma protuberans (DFSP). An 18‐month‐old girl presented large extremity DFSP. As surgical resection would have caused unacceptable functional defects, mesylate was administered to induce tumor reduction and or stabilization. After 23 weeks therapy, magnetic resonance imaging (MRI) showed subcutaneous thickness transverse plane. The drug tolerated well without any adverse reactions. Imatinib offers...
Background and objective: Handheld ultrasound, because of its light weight, size, rugged design, relative simplicity use is ideal for on operational military deployment. These machines have been used in the diagnosis a range traumatic conditions including abdominal, thoracic, extremity trauma hospital environment, yet few data exist their during operations. This paper presents experience handheld focused assessment with sonography (FAST) Method: Over two month period, FAST was performed by...
To address the need for a patient-reported outcome that can measure clinically and personally meaningful change in people with haemophilia (PwH) on prophylaxis, an approach based Goal Attainment Scaling (GAS) was developed: GAS-Hēm.To establish real-world feasibility of GAS-Hēm PwH.Patients aged 5-65 years were enroled from four North American centres 12-week study. The primary proportion participants who completed interviews at baseline, 6 12 weeks. scores obtained by subject-...
There is no uniform guideline for postchemotherapy vaccination of children with acute lymphoblastic leukemia (ALL). We evaluated waning immunity to 14 pneumococcal serotypes, pertussis toxin (PT), tetanus toxoid (TT) and varicella, immunogenicity diphtheria, tetanus, pertussis, hepatitis B, polio, Haemophilus influenzae type b (DTaP-IPV-Hib) among previously vaccinated treated ALL.This was a multicenter trial ALL enrolled 4-12 months completion. Exclusion criteria included: infant ALL,...
Abstract Introduction In many countries, there is a shift from standard half‐life (SHL) to extended (EHL) clotting factor concentrates (CFCs). Aim To describe the experience of switching SHL an EHL FVIII CFC and impact this on frequency infusions, consumption, bleeding rates HRQoL using Canadian Hemophilia Kids’ Life Assessment Tool (CHO‐KLAT). Methods A retrospective chart review was conducted at single haemophilia treatment centre in 2018 that included boys (ages: 4‐18 years) with...
Hand portable ultrasound has been validated in trauma patients using the FAST technique. The machine’s light and rugged design make it suitable for military deployment they have successfully used on deployments Kosovo, Afghanistan Iraq. Ultrasound is widely accepted diagnosis of abdominal thoracic trauma, however, little work exists its use extremity trauma. Although fractures usually relies X-ray this may not be readily available at Role 1 or 2. We identified long bone three hand during...
Dear Editor, Prophylactic factor VIII (FVIII) replacement is the current standard of care for severe haemophilia A but approximately 25%–40% patients develop inhibitors against exogenous FVIII, rendering FVIII therapy ineffective.1 Eradication high-titre involves immune tolerance induction (ITI): repeated, long-term administration high-dose FVIII.1 Recombinant Fc fusion protein (rFVIIIFc [ELOCTATE®, Sanofi, Waltham, MA]) first extended half-life approved A.2 Case reports and an initial...
Background Fever in the setting of neutropenia is a potentially life-threatening complication cancer treatment. A time less than 60 minutes from presentation to antibiotic administration therefore recommended. Objective To use Lean Six Sigma methodology, quality improvement initiative, improve antibiotics (TTA) for children with chemotherapy-induced febrile presenting emergency department. Methods method that engages all impacted stakeholders and focuses on streamlining process by removing...
Introduction The purpose of this study was to review and update the content Canadian Hemophilia Outcomes–Kids' Life Assessment Tool version 2.0 (CHO-KLAT), in context extended half-life (EHL) factor concentrates (FCs) establish validity reliability updated CHO-KLAT. Methods Focus groups were conducted with boys hemophilia, their parents, health care providers across Canada CHO-KLAT v2.0 determine if any modifications required. revised (version 3.0) then determined a sample hemophilia parents...
ABSTRACT Background Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors disease among hospitalized in Canada. Methods We conducted a national prospective on microbiologically confirmed SARS-CoV-2 infection via Canadian Paediatric Surveillance Program April 2020–May...
Hemophilia A and B are the most common of severe bleeding disorders. The present article focuses on practical aspects management neonates children diagnosed with hemophilia, is based questions frequently posed to paediatric hematologists. It highlights importance early diagnosis, principle intervention role comprehensive care hemophilia treatment centres.
Abstract Background Children living with chronic comorbid conditions are at increased risk for severe COVID-19 disease, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted therapies. Age-specific baseline indicators of severity also needed to evaluate effectiveness SARS-CoV-2 vaccination strategies in paediatric population. Objectives In this study, we aimed 1) identify factors children, 2) describe rates hospitalization,...