A5081458580- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Gestational Trophoblastic Disease Studies
- Higher Education Learning Practices
- Smart Cities and Technologies
- Mechanical Circulatory Support Devices
- Online Learning and Analytics
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Human Mobility and Location-Based Analysis
- Congenital Heart Disease Studies
- Online and Blended Learning
- Context-Aware Activity Recognition Systems
- COVID-19 and healthcare impacts
- Technology Adoption and User Behaviour
- Evaluation of Teaching Practices
- Green IT and Sustainability
- Big Data and Business Intelligence
- Higher Education Practises and Engagement
- Disaster Management and Resilience
- Higher Education and Employability
- Disaster Response and Management
Loughborough University
2013-2025
Canadian Paediatric Society
2021-2025
Parkland Health & Hospital System
2023
University of Saskatchewan
2021
Université de Montréal
2021
Dalhousie University
2021
University of Alberta
2021
Children's Hospital of Eastern Ontario
2021
Université de Sherbrooke
2021
Hospital for Sick Children
2021
<h3>Background:</h3> Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with Canada and identify risk more disease. <h3>Methods:</h3> conducted a national prospective study using the infrastructure Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted microbiologically confirmed reported from Apr. 8 Dec. 31 2020, through weekly online questionnaires...
This paper contributes new knowledge and understanding about the role that Product Passports might play in advancing sustainable business practices towards a Circular Economy. The significance of this research is proposed universal definition Digital Passport Ecosystem (DPPE) for international policy, industrial technical communities. novelty lies systems thinking approach, coupled with engineering, to define model DPPE as System Systems derive definition. Stakeholder perspectives...
A double blind, randomised, crossover placebo controlled trial of 5% acyclovir cream, applied topically five times a day for days, was carried out in 45 patients with recurrent herpes labialis. These had total 72 episodes, 34 which were treated the cream and 38 cream. Treatment begun by as soon possible after onset prodromal symptoms. There no significant clinical benefit from treatment compared The median healing nine days 10 13 when given. possibility that 40% propylene glycol base alone...
Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function Tregs large cohort HIV-1–infected individuals HIV-1 negative controls. While HIV "elite controllers" uninfected had similar Treg numbers frequencies, absolute declined blood gut-associated lymphoid tissue patients with chronic progressive infection. Despite quantitative...
Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors disease among hospitalized in Canada.We conducted a national prospective on microbiologically confirmed SARS-CoV-2 infection via Canadian Paediatric Surveillance Program (CPSP) April 2020-May 2021. Cases were...
Military systems, with their extended lifecycles, face challenges such as managing obsolescence, adapting to evolving operational needs, and ensuring interoperability in System of Systems contexts. Open Architectures (OAs) have been pursued address these issues by adopting widely recognized interface standards instead proprietary solutions, enabling more flexible cost-effective system modifications. However, establishing effective OA environments—encompassing technical, commercial,...
Interleukin-1 beta (IL-1 beta) is not detected in the amniotic fluid of normal human pregnancies before initiation parturition, but during labor, both at term and preterm, this cytokine present 25-40% pregnancies. A critical question, however, whether finding indicative a role for IL-1 (directly or indirectly) parturition result formation entry into as natural sequela labor. The forebag sac formed labor response to cervical dilatation, on decidual surface, tissues structure become exposed...
Purpose The purpose of this paper is to identify a business simulation appropriate for MEng Engineering students. selection was based on the following factors; exploring methods evaluating potential software and enhancing learner experience. Design/methodology/approach An interdisciplinary project team formed try resolve pedagogic, technical aspects that would need be addressed in order implement such within programme. Tools included questionnaire assess enhancement employability skills...
The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences infection a per-cell basis are still unknown. In vitro HIV-GFP and noninfected were isolated by flow-based cell-sorting to investigate Treg suppressive capacity gene expression profiles. Our data show HIV-1-infected significantly less than demonstrated down-regulation genes...
Purpose The purpose of this paper is twofold: to identify levels uptake performance measurement by small and medium‐sized retail companies selling goods online, determine key factors, which could explain any variation in use indicators. study designed explore these issues type retailer as currently understanding fairly limited. Design/methodology/approach A quantitative mail questionnaire was used survey UK retailers online. examined the conjunction with business profile each 252 responding...
Regulatory T cells (Tregs) are potent immune modulators, but their precise role in HIV pathogenesis remains incompletely understood. Most studies to date have focused on frequencies or phenotypes of 'bulk' Treg populations. However, although antigen-specific Tregs been reported other diseases, HIV-1 epitope-specific not described date. We here report the first identification functional HIV-1-Gag-specific regulatory using human leukocyte antigen class II tetramer staining HIV-1-infected individuals.
This paper describes a novel hackathon-style system engineering process and its value as an agile approach to the rapid generation development of early design concepts complex engineered products-in this case future aircraft. Complex product typically requires diverse range stakeholders arrive at consensus key decision criteria factors, which effective articulation communication information across traditional operational disciplines. The application methodology is highlighted by means study...
Product passports are an emerging data innovation positioned as information tool to enable sustainable and circular futures, where such futures delivered through increased more precise about resources, products, processes across the "product lifecycle". But this is a complex problem space traditional linear product lifecycles do not reflect nature lifespan of articulated passport types. This because records products per se (as name would suggest) but descriptions lifecycle activities...
ABSTRACT One of the goals Pennsylvania's juvenile justice system is “imposition accountability” for offenses committed. This White Paper, originally published in 2006, takes position that true accountability requires offenders to repair harm caused by their offending behavior and understand acknowledge wrongfulness actions, responsibility causing harm, impact crime on victim community. It identifies responsibilities, restorative practices, outcomes relative accountability. Paper was result...
While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context autoimmune diseases, transplantation cancer, their role HIV-1 pathogenesis remains less well defined. Controversy persists regarding beneficial or detrimental effects disease, which warrants further detailed exploration. Our objectives were to investigate if functional CD4+ Tregs can be isolated expanded from HIV-1-infected individuals for experimental...
Purpose This study aims to investigate the effectiveness of a theory-driven realist evaluative research approach better understand complex technology implementations in organizations. Design/methodology/approach An institution wide e-learning implementation lecture capture (LC), within UK University, was chosen, and evaluation framework used, tailored for educational technology. The conducted over four, increasingly focused, cycles combining engagement analytics, user interviews theory...
ABSTRACT Background Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated specific and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors disease among hospitalized in Canada. Methods We conducted a national prospective on microbiologically confirmed SARS-CoV-2 infection via Canadian Paediatric Surveillance Program April 2020–May...
The last couple of years have brought a rise in the number institutional repositories throughout world and within UK Higher Education institutions, with majority these being devoted to research output. Repositories containing teaching learning material are less common workflows business processes surrounding types were unclear. user motivations contributing downloading from also unknown. This article reports on two studies: wide-scale survey carried out HE staff identify barriers incentives...
Abstract Background Paediatric inflammatory multisystem syndrome (PIMS) is a rare but serious condition temporally associated with SARS-CoV-2 infection. Using the Canadian Surveillance Program (CPSP), national surveillance system, we aimed to 1) study impact of linkage on clinical and laboratory characteristics, outcomes in hospitalized children PIMS across Canada 2) identify risk factors for ICU admission, 3) establish minimum incidence hospitalizations due compare it acute COVID-19....
CD4+ Regulatory T cells (Tregs) are potent immune modulators and serve an important function in human homeostasis. Depletion of Tregs has led to measurable increases antigen-specific cell responses vaccine settings for cancer infectious pathogens. However, their role HIV-1 immuno-pathogenesis remains controversial, as they could either suppress deleterious HIV-1-associated activation thus slow disease progression or alternatively HIV-1-specific immunity thereby promote virus spread....