Tala El Tal
A5034910272- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- COVID-19 Impact on Reproduction
- Congenital Heart Disease Studies
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- COVID-19 and Mental Health
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
- Cytomegalovirus and herpesvirus research
- Lipid metabolism and disorders
- IgG4-Related and Inflammatory Diseases
- Health Policy Implementation Science
- Alzheimer's disease research and treatments
- Neuroblastoma Research and Treatments
- Vasculitis and related conditions
- Pharmacological Effects of Natural Compounds
- Neurogenesis and neuroplasticity mechanisms
- Dermatological and COVID-19 studies
- Inflammasome and immune disorders
- Health Systems, Economic Evaluations, Quality of Life
Hospital for Sick Children
2020-2024
Children's Hospital of Eastern Ontario
2024
University of Toronto
2021-2023
SickKids Foundation
2020-2023
Great Ormond Street Hospital
2023
University College London
2023
Western University
2022
American University of Beirut
2012-2017
<h3>Background:</h3> SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought investigate risk factors for admission the intensive care unit (ICU) and explored changes disease severity over time. <h3>Methods:</h3> obtained data from chart reviews of younger than 18 years with confirmed or probable MIS-C who were admitted 15 hospitals Canada, Iran Costa Rica between Mar. 1, 2020, 7, 2021. Using multivariable analyses, we evaluated whether date other...
KEY POINTS A 10-year-old previously healthy boy presented to the emergency department with 6 days of persistent fever; 4 abdominal pain, emesis and diarrhea; bilateral nonpurulent conjunctivitis red cracked lips. Four weeks before presentation, patient had 3 headache
To identify risk factors for severe disease in children hospitalised SARS-CoV-2 infection.Multicentre retrospective cohort study.18 hospitals Canada, Iran and Costa Rica from 1 February 2020 to 31 May 2021.Children<18 years of age symptomatic PCR-positive infection, including multisystem inflammatory syndrome (MIS-C).Severity on the WHO COVID-19 Clinical Progression Scale was used ordinal logistic regression analyses.We identified 403 hospitalisations. Median 3.78 (IQR 0.53-10.77). At least...
Objective Treat to target (T2T) is a strategy of adjusting treatment until reached. An international task force recommended T2T for juvenile idiopathic arthritis (JIA) treatment. Implementing in standard and reliable way clinical practice requires agreement on critical elements (1) setting, (2) strategy, (3) identifying barriers implementation, (4) patient eligibility. A consensus conference was held among Pediatric Rheumatology Care Outcomes Improvement Network (PR-COIN) stakeholders inform...
ABSTRACT: Background and Objectives: Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics prevalence in pediatric patients remain unclear. The objective of this study was to describe neurological a multinational cohort hospitalized SARS-CoV-2. Methods: This multicenter observational children <18 years age confirmed or multisystemic inflammatory syndrome (MIS-C) laboratory evidence children, admitted 15 tertiary...
Coagulopathy and thrombosis associated with SARS-CoV-2 infection are well defined in hospitalized adults leads to adverse outcomes. Pediatric studies limited.An international multicentered (n = 15) retrospective registry collected information on the clinical manifestations of multisystem inflammatory syndrome (MIS-C) children from February 1, 2020 through May 31, 2021. This sub-study focused coagulopathy. Study variables included patient demographics, comorbidities, presentation, hospital...
Abstract BACKGROUND SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We investigated risk factors for severe disease and explored changes severity over time. METHODS Children up 17 years of age admitted March 1, 2020 through 7 th , 2021 15 hospitals Canada, Iran Costa Rica with confirmed or probable MIS-C were included. Descriptive analysis comparison by diagnostic criteria, country, admission date was performed. Adjusted absolute average risks (AR)...
Background: Knowledge about neurological manifestations of SARS-CoV-2 in children is limited. We describe an international cohort hospitalized pediatric patients.Methods: This a multi-national observational study involving tertiary healthcare institutions Canada, Costa Rica and Iran. included patients 1 day-18 years admitted for any medical reason February 1, 2020-January 31, 2021 with laboratory evidence infection by RT-PCR or serological testing. Descriptive analyses logistic regression...
Abstract Background Paediatric inflammatory multisystem syndrome (PIMS) is a rare but serious condition temporally associated with SARS-CoV-2 infection. Using the Canadian Surveillance Program (CPSP), national surveillance system, we aimed to 1) study impact of linkage on clinical and laboratory characteristics, outcomes in hospitalized children PIMS across Canada 2) identify risk factors for ICU admission, 3) establish minimum incidence hospitalizations due compare it acute COVID-19....
Abstract Background Childhood-onset Systemic Lupus Erythematosus (cSLE) is an autoimmune disease associated with fatigue, mood symptoms, and pain. Fortunately, these symptoms are potentially modifiable psychological intervention such as cognitive-behavioral therapy (CBT). The Treatment Education Approach for (TEACH) program a CBT developed to target adolescents young adults cSLE. This pilot randomized controlled trial (RCT) aims determine the feasibility effect of TEACH youth Adjustments...
Background Mental health (MH) conditions are prevalent in adolescents with childhood-onset SLE (cSLE). Early identification is crucial preventing poor patient outcomes; however, MH screening rates remain low. Local problem From July 2021–January 2022, only 15% of a paediatric tertiary care cSLE clinic were being screened for depression and anxiety. By November 2023, we aimed to increase the percentage patients (≥12–18 years) (Patient Health Questionnaire: PHQ-9) anxiety (Generalised Anxiety...
Introduction: Measurement-Based Care (MBC) is the routine, systematic use of validated measures (e.g., patient-reported outcome [PROMs]) before or during clinical encounters to inform treatment decision-making. A large body evidence, including randomized controlled trials, suggest that MBC outperforms usual care in response treatment, remission rates, time and for individuals with depression, anxiety other mental health conditions. a standard most chronic conditions diabetes, hypertension,...
POINTS CLÉS Un garçon de 10 ans jusqu'ici en santé arrive à l'urgence. Il a une fièvre qui persiste depuis 6 jours; se plaint douleurs l'abdomen et des vomissements la diarrhée 4 présente conjonctivite bilatérale non purulente; les lèvres rouges
Background: The full clinical continuum of post-COVID-associated multisystem inflammatory syndrome childhood (MIS-C)/Paediatric Inflammatory Multi-system Syndrome (PIMS) is still being defined, with different names and case definitions continuing to be used across jurisdictions. Refinement criteria better stratification affected children will facilitate international collaborations towards improving health outcomes. Our objective describe the characteristics outcomes MIS-C/PIMS stratified by...
<h3>Background</h3> Cognitive complaints are common in children with childhood-onset systemic lupus erythematosus (cSLE), but neuropsychiatric (NPSLE) remains challenging to diagnose and treat. To increase understanding of contributing mechanisms, we examined the association between cognitive function, disease measures structural neuroimaging metrics. <h3>Methods</h3> We a cross-sectional sample 24 patients cSLE (ages 12-17) meeting ACR or SLICC classification criteria. Patients completed...
Contexte : Une comparaison de la gravité maladie et l'utilisation des ressources entre les hospitalisations pédiatriques pour à coronavirus aiguë 2019 (COVID-19) le syndrome inflammatoire multisystémique chez enfants (SIME) pourrait aider planification soins santé.Cet article décrit fardeau hospitalier absolu relatif COVID-19 pédiatrique du SIME au Canada.Méthodes Cette étude prospective nationale a été menée dans cadre Programme canadien surveillance mars 2020 mai 2021.Les moins 18 ans...
Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning.We describe the absolute relative hospital burden COVID-19 MIS-C Canada.Methods: This national prospective study was conducted via Canadian Paediatric Surveillance Program from March 2020-May 2021.Children younger than 18 years old hospitalized or were included analysis.Outcomes supplemental...
Abstract Purpose: The objective of this study was to describe the clinical course and outcomes in children with technology-dependence (TD) hospitalized SARS-CoV-2 infection.Methods: Seventeen pediatric hospitals (15 Canadian one each Iran Costa Rica) included up 17 years age admitted February 1, 2020, through May 31, 2021, detection SARS-CoV-2. For those TD, data were collected on demographics, outcome. Results: Of 691 entered database, 42 (6%) had TD which 22 feeding tube dependence only, 9...
ABSTRACT Direct comparisons of pediatric hospitalizations for acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. While there were more deaths from amongst Canadian between March 2020–May 2021, MIS-C cases severe, requiring intensive care vasopressor support.