A5103121612- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Cerebrospinal fluid and hydrocephalus
- Bacterial Infections and Vaccines
- Long-Term Effects of COVID-19
- Neonatal and Maternal Infections
- Eosinophilic Disorders and Syndromes
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Medical research and treatments
- Glaucoma and retinal disorders
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Restraint-Related Deaths
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Central Venous Catheters and Hemodialysis
McGill University Health Centre
2015-2024
Montreal Children's Hospital
2010-2024
Centre Hospitalier de Lens
2024
McGill University
2010-2023
New York Proton Center
2023
Communities In Schools of Orange County
2023
Manhattan Institute for Policy Research
2023
Oregon Medical Research Center
2023
Lindsay Unified School District
2023
Western University
2022
The COVID-19 pandemic resulted in unprecedented implementation of wide-ranging public health measures globally. During the pandemic, dramatic decreases seasonal influenza virus detection have been reported worldwide. Information on impact paediatric influenza-related hospitalisations is limited. We describe hospitalisation children Canada following onset pandemic. Data hospitalisations, intensive care unit (ICU) admissions and in-hospital deaths across were obtained from Canadian...
<h3>Background:</h3> SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought investigate risk factors for admission the intensive care unit (ICU) and explored changes disease severity over time. <h3>Methods:</h3> obtained data from chart reviews of younger than 18 years with confirmed or probable MIS-C who were admitted 15 hospitals Canada, Iran Costa Rica between Mar. 1, 2020, 7, 2021. Using multivariable analyses, we evaluated whether date other...
Retrospective and prospective demographic health data collected on the population of Mlomp (6352 people in 1985), a rural area Senegal, show that probability dying before age 5 years declined from 350 to 81 deaths per hundred livebirths last 25 years. This dedine is greater faster than ever observed Senegal. The drop mortality mainly results improved access new efficient services-a dispensary maternity clinic-and growth surveillance, education, vaccination malaria programmes initiated 1960s...
Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation some countries for vaccination against during pregnancy. Having data on the burden of pediatric large population over time is important establishing true disease acellular (aP) vaccine era. Here, we describe age-specific epidemiology children hospitalized with 17 years across Canada aP
To identify risk factors for severe disease in children hospitalised SARS-CoV-2 infection.Multicentre retrospective cohort study.18 hospitals Canada, Iran and Costa Rica from 1 February 2020 to 31 May 2021.Children<18 years of age symptomatic PCR-positive infection, including multisystem inflammatory syndrome (MIS-C).Severity on the WHO COVID-19 Clinical Progression Scale was used ordinal logistic regression analyses.We identified 403 hospitalisations. Median 3.78 (IQR 0.53-10.77). At least...
ABSTRACT: Background and Objectives: Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics prevalence in pediatric patients remain unclear. The objective of this study was to describe neurological a multinational cohort hospitalized SARS-CoV-2. Methods: This multicenter observational children <18 years age confirmed or multisystemic inflammatory syndrome (MIS-C) laboratory evidence children, admitted 15 tertiary...
Fischer-344 rats were exposed for 4 hours to 0, 14, 280, or 560 mg of hydrogen sulfide.m-3 and killed 1, 18, 44 later. We evaluated the nasal epithelial cells determined anatomic distribution lesions. Inhalation induced necrosis exfoliation respiratory olfactory mucosal cells, but not squamous cells. The lesions was midway along passages involving maxillary conchae, ethmoidal conchae. Injured mucosa repaired rapidly, whereas continued exfoliate at after exposure.
Coagulopathy and thrombosis associated with SARS-CoV-2 infection are well defined in hospitalized adults leads to adverse outcomes. Pediatric studies limited.An international multicentered (n = 15) retrospective registry collected information on the clinical manifestations of multisystem inflammatory syndrome (MIS-C) children from February 1, 2020 through May 31, 2021. This sub-study focused coagulopathy. Study variables included patient demographics, comorbidities, presentation, hospital...
The incidence of healthcare-associated viral respiratory infections in a pediatric hospital decreased from 1.6 /1,000 patient-days 2019 to 0.2 2020 (P < .01), and this was maintained 2021 despite an increase community circulation viruses. Universal masking, stricter infection control measures, pandemic public health interventions likely accounted for improvement.
Globally there is an increased prevalence of carbapenem-resistant Acinetobacter spp. (CRAs) and carbapenemase-producing (CPAs) in the hospital setting. This increase prompted Canadian Nosocomial Infection Surveillance Program (CNISP) to conduct surveillance CRA colonizations infections identified from patients CNISP-participating hospitals between 2010 2016.Participating acute care facilities across Canada submitted CRAs 1 January 31 December 2016. Patient data were collected medical records...
Abstract BACKGROUND SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We investigated risk factors for severe disease and explored changes severity over time. METHODS Children up 17 years of age admitted March 1, 2020 through 7 th , 2021 15 hospitals Canada, Iran Costa Rica with confirmed or probable MIS-C were included. Descriptive analysis comparison by diagnostic criteria, country, admission date was performed. Adjusted absolute average risks (AR)...
To determine the association between implementation of an antimicrobial stewardship program at a local PICU and to presence programs use across three Canadian PICUs, among critically ill children with bronchiolitis.A multicenter retrospective cohort study.Three PICUs over two winter seasons.An was implemented 1 end season 1.Patients less than or equal 2 years old admitted bronchiolitis.We used regression models interaction term site (PICU 2) (1 as primary analysis 1) proportion...
Background: Knowledge about neurological manifestations of SARS-CoV-2 in children is limited. We describe an international cohort hospitalized pediatric patients.Methods: This a multi-national observational study involving tertiary healthcare institutions Canada, Costa Rica and Iran. included patients 1 day-18 years admitted for any medical reason February 1, 2020-January 31, 2021 with laboratory evidence infection by RT-PCR or serological testing. Descriptive analyses logistic regression...
Infections complicate 5%-10% of cerebrospinal fluid (CSF) shunts. We aimed to describe the characteristics and contemporary pathogens shunt infections in children Canada United States.Descriptive case series at tertiary care hospitals (N = 8) States 3) up 18 years age with CSF from July 1, 2013, through June 30, 2019.There were 154 (43% female, median 2.7 years, 50% premature) ≥1 infections. Median time between placement infection was 54 days (interquartile range, 24 days-2.3 years). Common...
OBJECTIVE Cerebrospinal fluid (CSF) white blood cell (WBC) count, neutrophil percentage, protein concentration, and glucose level are typically measured at diagnosis serially during the treatment of CSF shunt infections. The objective this retrospective cohort study was to describe longitudinal profile parameters in children with infections assess their association outcome. METHODS Participants were treated 11 tertiary pediatric hospitals Canada United States for infection, from July 1,...
Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV. It presents fever and systemic symptoms extremely uncommon children. We describe novel case of multicentric associated primary immunodeficiency (common variable immunodeficiency) discuss pathophysiologic mechanisms recent advances understanding this disease. Pediatr Blood Cancer. 2010;55:1198–1200. © 2010 Wiley-Liss, Inc.
We performed a molecular and epidemiologic study of healthcare-associated rhinovirus outbreak to better understand transmission in neonatal intensive care settings. Sequencing the 7 strains revealed 4 distinct clades, indicating multiple sources. A single clade infected 3 patients adjacent rooms, suggesting horizontal transmission. observed 1 rhinovirus-associated death.
This study describes trends in COVID-19 hospitalizations and healthcare-associated (HA) Canada among pediatric (age <18 years) patients during pre-Omicron Omicron-dominant periods.
CASE PRESENTATION A nine-week-old girl presented to the emergency department with a 12 h history of fever and 1 min generalized tonic-clonic seizure. Review systems was otherwise negative. Her two-year-old sister experienced oropharyngeal ulcers two weeks before. On physical examination, she febrile 39.2°C rectal, but normal vital signs. She well-appearing her examination normal, including neurological examination. Blood, urine cerebrospinal fluid (CSF) specimens were obtained, intravenous...