A5012783501- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- Hormonal Regulation and Hypertension
- Canadian Identity and History
- Pharmaceutical studies and practices
- Neonatal Respiratory Health Research
- Pharmacological Effects and Toxicity Studies
- Historical and Literary Analyses
- Influenza Virus Research Studies
- Historical and Literary Studies
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Adverse Reactions
- Cystic Fibrosis Research Advances
- Bacterial Identification and Susceptibility Testing
- Analytical Chemistry and Chromatography
- Anesthesia and Sedative Agents
- Birth, Development, and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacology and Obesity Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
Centre Hospitalier Universitaire Sainte-Justine
2012-2024
Impact
2023
Université de Montréal
2004-2020
Hôpital Saint-Louis
2020
Cité des Sciences et de l'Industrie
2014
Shell (Japan)
2014
Université Laval
1993-2008
Hôtel-Dieu de Québec
1978-2008
Centre hospitalier universitaire de Québec
1999-2008
Library and Archives Canada
1993-2007
We enrolled 200 infants and older children with bacterial meningitis in two prospective double-blind, placebo-controlled trials to evaluate the efficacy of dexamethasone therapy addition either cefuroxime (Study 1) or ceftriaxone 2). Altogether, 98 patients received placebo 102 (0.15 mg per kilogram body weight every six hours for four days). At beginning therapy, clinical demographic characteristics treatment groups were comparable. The mean increase cerebrospinal fluid concentration...
Background: Infants born at 33 through 35 completed weeks of gestation (33-35GA) are risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations RSV infection by as much 80%. The 33-35GA cohort comprises 3-5% annual births; thus expert panels recommend limiting to situations in which frequency or health care impact is high. This study sought identify independent factors hospitalization infection. Methods: was a multicenter, prospective,...
To determine the clinical importance of CSF cultures that are persistently positive for pathogens in patients treated meningitis with new cephalosporins, records 301 infants and children bacterial enrolled prospectively four efficacy trials cefuroxime or ceftriaxone therapy were reviewed. culture results 20 they sterile at 18 to 36 hours after start 281 patients. Seizures, subdural effusions, hemiparesis found significantly more often during hospitalization those delayed sterilization CSF....
Importance Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalizations. Objective To describe the epidemiology and burden RSV-associated hospitalizations among children adolescents in Canadian tertiary hospitals from 2017 to 2022, including changes during COVID-19 pandemic. Design, Setting, Participants This cross-sectional study was conducted 5 RSV seasons (2017-2018 2021-2022) at 13 care centers Immunization Monitoring Program Active (IMPACT) program. Hospitalized...
To assess the morbidity associated with continued high levels of pertussis, we studied all children .2 years age who were admitted to 11 Immunization Monitoring Program-Active (IMPACT) centers, which constitute 85% Canada's tertiary care pediatric beds. In 7 preceding implementation acellular pertussis vaccine, a total 1,082 cases reported, 49.1% culture-confirmed. The median patients was 12.4 weeks; 78.9% in <6 months age. Complications common: pneumonia reported 9.4% cases, new seizures...
The COVID-19 pandemic resulted in unprecedented implementation of wide-ranging public health measures globally. During the pandemic, dramatic decreases seasonal influenza virus detection have been reported worldwide. Information on impact paediatric influenza-related hospitalisations is limited. We describe hospitalisation children Canada following onset pandemic. Data hospitalisations, intensive care unit (ICU) admissions and in-hospital deaths across were obtained from Canadian...
Background Substrates and inhibitors of the cytochrome P450 isozyme CYP2D6 have overlapping structural characteristics. Two prototype serotonin uptake inhibitors, sertraline fluoxetine, share these criteria been identified as potent in vitro. The current study was undertaken to investigate whether genetically determined activity alters disposition or fluoxetine both. Methods Single doses (50 mg) (20 were administered successively 20 young men with high (extensive metabolizers; n = 10) low...
In a retrospective review of 214 children with nephrotic syndrome seen at Children's Medical Center and Parkland Memorial Hospital in Dallas throughout the 20-year period from 1967 to 1986, 62 cases primary peritonitis were identified 37 patients (17.3% rate). Streptococcus pneumoniae was major pathogen, accounting for 38% cases. An additional 27% had negative culture results but clinically responsive penicillin. Gram-negative organisms cultured only 3% patients; 5% caused by...
We undertook a prospective, double-blind, placebo-controlled trial to resolve the question of clinical effectiveness ribavirin in previously well infants who require ventilation for respiratory distress secondary syncytial virus (RSV) bronchiolitis. Aerosol or NaCl 0.9% was administered within 24 h initiation ventilation, 18 / d, maximum 7 d until extubation. From March 1994 1997, 42 children were randomized and 41 patients retained analysis. Baseline characteristics each group—ribavirin...
The pharmacokinetics of ciprofloxacin and its metabolite 1 (desethyleneciprofloxacin) were studied in 17 obese men (mean age, 29.2 ± 7.5 years; mean weight, 110.7 20.2 kg; body mass index, 36.4 3.9 kg/m2) 11 control subjects (men normal weight; 25.0 ±5.1 71.8 9.9 23.3 2.4 kg/m2). Each subject received a single 400 mg intravenous dose infused over hour. Ciprofloxacin total clearance was significantly increased compared with (897.44 159.57 versus 744.44 120.51 ml/min, respectively; p < 0.05)....
• We conducted a third placebo-controlled, double-blind study of dexamethasone as adjunctive therapy for bacterial meningitis. Thirty-one patients received cefuroxime sodium (300 mg/kg per day in 3 doses) and phosphate (0.6 4 doses days), 29 placebo. The groups were comparable at the beginning therapy. Magnetic resonance imaging performed between days 2 5 was used to assess brain water content indirectly. There no differences treatment with respect T<sub>1</sub>- or T<sub>2</sub>-weighted...
OBJECTIVES. Influenza is a common childhood infection that may result in hospitalization. Our objectives were to (1) determine characteristics of children hospitalized for influenza and disease manifestations (2) obtain baseline data before implementation new recommendations routine immunization young their caretakers against influenza. METHODS. All the with laboratory-confirmed at 9 Canadian tertiary care hospitals during 2003–2004 season identified from virology laboratory reports, charts...
Reports on fatal benzyl alcohol poisoning in premature neonates implied that the toxicity may be due to larger doses per kilogram than for adults. It has been postulated load of benzoic acid (metabolite alcohol) exceed capacity immature liver or kidney detoxification through glycine conjugation form hippuric acid. To test this hypothesis, 14 term and 9 preterm receiving loading phénobarbital containing were studied. Urine serum levels measured by GC HPLC methods, respectively. There was...
Background. Pertussis is still a prevalent public health problem, and antibiotic therapy may decrease disease severity limit communicability. Erythromycin the recommended for treatment prophylaxis of pertussis; however, side effects erythromycin its usefulness in some patients. Clarithromycin, newer macrolide, has good vitro activity against Bordetella pertussis better effect profile. Goals study. To compare microbiologic clinical efficacy safety 7-day course clarithromycin vs. 14-day...
A retrospective review of children who needed mechanical ventilation for severe bronchiolitis identified 62 cases over a 10 year period. The mean age at initiation was 73 days (range: 14-201). Compared with group 150 in hospital but not transferred to the intensive care unit, these were significantly younger (73.0 compared 166.3 days), and smaller (4.5 6.8 kg), more had been born prematurely (40% 16%). Taken independently, age, weight, prematurity associated need artificial ventilation,...
The pharmacokinetics and blister fluid penetration of oral ciprofloxacin were compared in 11 cystic fibrosis (CF) patients who had sputum colonization but asymptomatic 12 healthy volunteers after a single dose (500 mg) at steady state mg every 8 h). antibacterial effect therapy was also evaluated by bacterial counts colonizing pathogens the respiratory secretions CF patients. 15.9% lighter weight than controls (P less 0.05). After dose, elimination half-life decreased third as with (2.62...
To evaluate the impact of a preliminary positive blood culture result, subsequently confirmed to be false result on rate hospitalization, antibiotic therapy and use microbiologic tests.Retrospective chart review.Children between 1 month 18 years old whom was performed were eligible, excluding those with an underlying condition for may difficult assess. During 1-year study period 9959 cultures which 778 (7.8%) produced growth. Charts 81 patients reviewed compared 162 true negative culture....
This open‐label, randomized, three‐way crossover study of 28 healthy premenopausal women was conducted to compare the impact concomitant rifabutin and rifampicin on safety, pharmacokinetics, pharmacodynamics oral contraceptives ethinylestradiol norethindrone (Ortho‐Novum 1/35; Ortho Pharmaceutical, Raritan, NJ). Each participant received daily for 21 days first control cycle, then randomized one two sequences receive with at equal doses 300 mg/day 10 days. Ethinylestradiol, norethindrone,...
We compared the pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, ciprofloxacin. Fifteen healthy volunteers received 1 g ceftriaxone intravenously, 500 mg imipenem-cilastatin ciprofloxacin orally. High-performance liquid chromatographic assays were used to quantitate unchanged antibiotic in plasma urine. Serum determined against six clinical isolates each Staphylococcus aureus, Enterobacter cloacae, Pseudomonas aeruginosa by using a modified...
The pathophysiological events that are believed to contribute adverse outcome from bacterial meningitis include alteration of cerebral capillary endothelial cells comprise the blood-brain barrier, cytotoxic and vasogenic edema, loss autoregulation, increased intracranial pressure.<sup>1</sup>These alterations can lead a reduction in perfusion pressure diminution blood flow. This results regional hypoxia focal ischemia brain tissue, possibly manifested as neurologic sequelae, learning or...
The pharmacokinetics and the suction-induced blister fluid penetration of ciprofloxacin were compared after a single dose (500 mg) multiple dosing mg q8h for 13 doses). Significantly higher peak levels in serum observed (3.51 versus 2.26 micrograms/ml; P less than 0.01). Increased elimination half-life occurred dosing; this seems to be mostly related decreased systemic clearance secondary diminished nonrenal (240.0 125.0 ml/min). Ciprofloxacin appeared rapidly fluid, percentage...