A5091839466- Radiation Dose and Imaging
- Radioactivity and Radon Measurements
- Radioactive contamination and transfer
- Radioactive element chemistry and processing
- Nuclear and radioactivity studies
- Graphite, nuclear technology, radiation studies
- Effects of Radiation Exposure
- Radiopharmaceutical Chemistry and Applications
- Air Quality and Health Impacts
- Radiation Therapy and Dosimetry
- Carcinogens and Genotoxicity Assessment
- Schizophrenia research and treatment
- Trace Elements in Health
- Medical Imaging Techniques and Applications
- Advancements in Transdermal Drug Delivery
- Risk and Safety Analysis
- Contact Dermatitis and Allergies
- Nuclear Materials and Properties
- Radioactive Decay and Measurement Techniques
- Cavitation Phenomena in Pumps
- Heavy Metal Exposure and Toxicity
- Municipal Solid Waste Management
- Drug Transport and Resistance Mechanisms
- Risk Perception and Management
- Vitamin D Research Studies
Institut de Radioprotection et de Sûreté Nucléaire
2010-2022
Université Laval
1990-2021
Centre intégré de santé et de services sociaux de Chaudière-Appalaches
2021
Cégep de Sorel-Tracy
2010-2014
Cardiff University
2014
Alstom (France)
2012
Alstom (Canada)
2010
CEA Cadarache
2008
Université du Québec à Montréal
1999-2007
Lear (United States)
2007
The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect calculation effective dose, and implied a revision dose coefficients for internal exposure, published previously in Publication 30 series 1979, 1980, 1981, 1988) 68 1994). In addition, new data are now available support an update radionuclide-specific information given Publications 54 78 1988a, 1997b) design monitoring programmes retrospective assessment...
The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect calculation effective dose, and implied a revision dose coefficients for internal exposure, published previously in Publication 30 series 1979, 1980, 1981, 1988b) 68 1994b). In addition, new data are available support an update radionuclide-specific information given Publications 54 78 1988a, 1997b) design monitoring programmes retrospective assessment occupational...
The 2007 Recommendations (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision dose coefficients for internal exposure, published previously in Publication 30 series 1979a,b, 1980a, 1981, 1988) 68 1994b). In addition, new data are now available support an update radionuclide-specific information given Publications 54 78 1989a, 1997) design monitoring programmes retrospective assessment occupational doses. Provision biokinetic models,...
Background Substrates and inhibitors of the cytochrome P450 isozyme CYP2D6 have overlapping structural characteristics. Two prototype serotonin uptake inhibitors, sertraline fluoxetine, share these criteria been identified as potent in vitro. The current study was undertaken to investigate whether genetically determined activity alters disposition or fluoxetine both. Methods Single doses (50 mg) (20 were administered successively 20 young men with high (extensive metabolizers; n = 10) low...
Depleted uranium (DU) is a radioactive heavy metal coming from the nuclear industry and used in numerous military applications. Uranium inhalation can lead to development of fibrosis neoplasia lungs. As little known concerning molecular processes leading these pathological effects, some events terms genotoxicity inflammation were investigated rats exposed DU by inhalation. Our results show that exposure resulted DNA strand breaks broncho-alveolar lavage (BAL) cells increase inflammatory...
Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about effects long-term environmental exposure. Using a combination conventional biochemical studies and serial analysis gene expression (SAGE), we examined renal responses to uranyl nitrate (UN) chronic Renal levels were significantly increased 4 months after ingestion in drinking water. Creatinine serum slightly but compared with those controls. no further significant...
The ICRP Task Group on Internal Dosimetry is developing new Occupational Intakes of Radionuclides (OIR) documents. Application the Human Respiratory Tract Model (HRTM) requires a review lung-to-blood absorption characteristics inhaled compounds importance in radiological protection. Where appropriate, material-specific parameter values will be given, and for other compounds, assignments to default Types made current information. Publication OIR provides an opportunity updating HRTM light...
This open‐label, randomized, three‐way crossover study of 28 healthy premenopausal women was conducted to compare the impact concomitant rifabutin and rifampicin on safety, pharmacokinetics, pharmacodynamics oral contraceptives ethinylestradiol norethindrone (Ortho‐Novum 1/35; Ortho Pharmaceutical, Raritan, NJ). Each participant received daily for 21 days first control cycle, then randomized one two sequences receive with at equal doses 300 mg/day 10 days. Ethinylestradiol, norethindrone,...
Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about effects long-term environmental exposure.Using a combination conventional biochemical studies and serial analysis gene expression (SAGE), we examined renal responses to uranyl nitrate (UN) chronic exposure.Renal levels were significantly increased 4 months after ingestion in drinking water.Creatinine serum slightly but compared with those controls.Although no further...
Chemical and radiological toxicities related to uranium acute exposure have been widely studied in nuclear fuel workers military personnel. It is well known that uranyl nitrate induces renal failure (ARF). However, the mechanisms of this metal-induced injury are not defined at molecular level.Renal function histology were assessed mice receiving (UN(+)) controls (UN(-)). To identify genomic response exposure, serial analysis gene expression (SAGE) kidney was performed both groups. Over...
The environmental contamination by dispersion of depleted uranium (DU) might result in its chronic ingestion DU local populations. aim this study was to determine if at low doses induces inflammatory reactions intestine, first biological system exposed after ingestion. Experiments were performed with rats receiving drinking water (40 mg/l) during 3, 6, or 9 months. Several parameters referring prostaglandin, histamine, cytokine, and nitric oxide (NO) pathways assessed ileum. Concerning the...
Epidemiological studies of the occupational exposure miners and domestic exposures public have provided strong complementary evidence risks lung cancer following inhalation radon progeny. Recent miner epidemiological studies, which include low levels exposure, long duration follow-up, good quality individual data, suggest higher per unit than assumed previously by International Commission on Radiological Protection (ICRP). Although can be managed controlling exposures, dose estimates are...
The striatum is known to play a primary role in procedural learning. In this study, the authors simultaneously assessed effects of two antipsychotic drugs on learning and striatal dopamine (D2) receptor occupancy. Twenty-seven patients receiving either olanzapine or haloperidol as medication were with Computed Visual Tracking Task (CVTT) Single Photon Emission Tomography (SPECT) following administration Iodine 123-IBZM (123I-IBZM), radioligand high affinity specificity for D2 receptors....
In order to optimise the monitoring of potentially exposed workers, it is desirable determine specific values absorption for compounds handled. This study derives rates different chemical forms plutonium from in vitro and animal (monkeys, dogs, mice, rats) experiments, human contamination cases. Different published experimental data have been reinterpreted here derive parameters, f(r), s(r) s(s), used respiratory tract model currently adopted by International Commission on Radiological...