A5086479743- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Sleep and related disorders
- Restless Legs Syndrome Research
- Obstructive Sleep Apnea Research
- Attention Deficit Hyperactivity Disorder
- Mental Health and Psychiatry
- Neuroscience and Music Perception
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Cholinesterase and Neurodegenerative Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Transcranial Magnetic Stimulation Studies
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
Montreal Neurological Institute and Hospital
2013-2024
Université du Québec à Montréal
2014-2024
McGill University
1997-2024
Douglas Mental Health University Institute
2002-2022
Ottawa Hospital
2011-2012
Carleton University
2011-2012
University of Ottawa
2011
Hôpital du Sacré-Cœur de Montréal
1987-2004
Université de Montréal
1987-2004
Hôpital Louis-H Lafontaine
2000-2004
<b><i><i>Objective:</i></i></b> To determine the frequency of REM sleep behavior disorder (RBD) among patients with PD using both history and polysomnography (PSG) recordings to further study muscle atonia in PD. <b><i>Background: </i></b> The reported occurrence RBD varies from 15 47%. However, no has estimated PSG or analyzed detail characteristics a large group unselected <b><i>Methods: Consecutive (n = 33) healthy control subjects 16) were studied. Each subject underwent structured...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles...
Abstract Neuropsychological deficits have been documented in patients with obstructive sleep apnea syndrome (OSSA). Both nocturnal hypoxemia and impairment of daytime vigilance suggested as the pathogenesis these deficits, yet it remains difficult to find good correlations between cognitive either physiological parameters. In present study, 10 normal controls were compared moderately severely apneic patients, all recorded a laboratory for two consecutive nights, neuropsychological assessment...
Abstract The obstructive sleep apnea syndrome is characterized by nocturnal disturbance, excessive daytime sleepiness and neuropsychological deficits in the areas of memory, attention, executive tasks. In present study, these clinical manifestations were assessed apneic patients before 6 months after treatment with nasally applied continuous positive airway pressure (CPAP). CPAP was found to restore normal respiration during normalize organization. Daytime vigilance greatly improved but some...
There is a lack of data about the practice effect and test-retest reliability (TRR) on many attentional executive tests in neuropsychology. In this study, 37 subjects aged 52 to 80 were tested three times with an inter-assessment interval 14 days. The battery included Rey Auditory Verbal Learning Test, Stroop interference test, Letter-Number Sequencing Wechsler Adult Intelligence Scale-III (WAIS-III), Ruff 2 7 Selective Attention Tower London, Fluency simple, choice, sequential reaction time...
Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent apneas during sleep, resulting in repetitive hypoxemic episodes and a constant interruption of the normal pattern. Vigilance impairment neuropsychological deficits are among main symptoms seen this condition. One major questions field concerns reciprocal interactions between nocturnal hypoxemia, disruption, excessive daytime sleepiness cognitive deficits. Results study suggest that vigilance attributable mostly to...
Summary: Seven patients suffering from restless legs syndrome (RLS) and periodic movements in sleep (PMS) were investigated before after treatment with L-Dopa. The effect of was evaluated by polysomnography, structured interviews, daily questionnaires. Sleep organization subjective complaints improved during 100 to 200 mg Polysomnographic recordings also revealed a significant decrease leg the first third night rebound last third. These results previous biochemical findings raise hypothesis...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative 19 transporters across 9 different neurotransmitter systems. We find that profiles align with structural...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography scans >1,200 healthy individuals to construct a whole-brain 3-D normative 18 transporters across 9 different neurotransmitter systems. We find that profiles align with structural...
To compare nondemented patients with Parkinson's disease (PD) and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness sleep.Fifteen PD (7 polysomnographic-confirmed RBD [PD-RBD] 8 [PD-NRBD]) 15 control subjects were studied. Each subject underwent a analysis of sleep.During wakefulness, PD-RBD showed higher theta power in frontal, parietal, temporal, occipital regions comparison PD-NRBD subjects. Moreover, slowing the...
Gamma-hydroxybutyrate (GHB) is a drug currently used to treat narcolepsy. The present study documents its effect on sleep organization in healthy subjects. GHB and placebo were given at bedtime before morning nap double-blind fashion. administered nocturnal or diurnal increases stages 3 4 decreases stage 1 non-rapid eye movement (NREM) sleep. In addition, improves REM efficiency night reduces wake time after onset when recording. also slightly latency the morning, this correlated with age....
Sleep architecture and quantitative EEG from wakefulness REM sleep were studied in six patients (mean age, 70.5 years) with progressive supranuclear palsy (PSP) compared that of control subjects 69.8 years). Particular attention was given to quantifying variables because the known PSP-associated degeneration pedunculopontine tegmentum (PPT)-a critical structure generation. Patients PSP had a shorter total time, lower efficiency, drastic reduction spindles, an atonic slow-wave sleep,...
Rationale . Alzheimer’s Disease (AD) is a neurodegenerative condition characterized in part by deficits cholinergic basalocortical and septohippocampal pathways. [ 18 F]Fluoroethoxybenzovesamicol ([ F]FEOBV), Positron Emission Tomography ligand for the vesicular acetylcholine transporter (VAChT), potential molecular agent to investigate brain diseases associated with presynaptic losses. Purpose To demonstrate this potential, we carried out an F]FEOBV autoradiography study compare postmortem...