A5056824288- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Neuroscience and Neuropharmacology Research
- Advanced X-ray and CT Imaging
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Lanthanide and Transition Metal Complexes
- Radiation Detection and Scintillator Technologies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
Yale University
2016-2024
Laboratoire d’Imagerie Biomédicale
2024
Yale Cancer Center
2023
McGill University
2009-2020
Montreal Neurological Institute and Hospital
2006-2020
University of Pennsylvania
2018-2020
Philadelphia University
2020
Concordia University
2016-2017
University of Antwerp
2016
Université de Montréal
2016
<b>Objective: </b> To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) order to establish topography of networks involved. <b>Methods: We performed blood flow evaluation using <sup>99m</sup>Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made SPM2. <b>Results: found increased pons putamen bilaterally right hippocampus. In addition, we observed a decreased...
In laboratory animals, environmental stressors markedly activate the mesocortical dopamine system. The present study tested whether this occurs in humans.The effects of a psychological stressor (Montreal Imaging Stress Task, MIST) on release healthy young adults (11 males, mean age ± SD, 20.6 2.4 years) was measured using positron emission tomography and [(18)F]fallypride. Each subject scanned two separate days counterbalanced order: one with MIST control task. Binding potential (BP ND )...
Accumulating evidence indicates that drug-related cues can induce dopamine (DA) release in the striatum of substance abusers. Whether these same provoke DA human prefrontal cortex remains unknown.We used high-resolution positron emission tomography with [18F]fallypride to measure cortical and striatal D2/3 receptor availability presence versus absence volunteers current cocaine dependence.Twelve individuals participated our study. Among participants reporting a craving response (9 12),...
Abstract Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these treatment modalities. Here, we used positron emission tomography α-[ 11 C]methyl- l -tryptophan tracer examine in brain regional synthesis capacity OCD following CBT or SSRI treatment. Sixteen medication-free were randomly assigned 12 weeks...
Background Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait. Methodology/Principal Findings In present study, positron emission tomography with tracer alpha-[11C]methyl-L-tryptophan (11C-AMT) was used to compare synthesis capacity in two groups adult males from 21-year longitudinal study (mean age ± SD:...
Idiopathic hypersomnia is characterized by excessive daytime sleepiness, despite normal or long sleep time. Its pathophysiological mechanisms remain unclear. This pilot study aims at characterizing the neural correlates of idiopathic using single photon emission computed tomography. Thirteen participants with and 16 healthy controls were scanned during resting wakefulness a high-resolution tomography scanner 99mTc-ethyl cysteinate dimer to assess cerebral blood flow. The main analysis...
Awareness is an essential feature of the human mind that can be directed internally, is, toward our self, or externally, environment.The combination internal and external information crucial to constitute sense self.Although underlying neuronal networks, so-called intrinsic extrinsic systems, have been well-defined, associated biochemical mechanisms still remain unclear.We used a well-established functional magnetic resonance imaging (fMRI) paradigm for (heartbeat counting) (tone awareness...
Recent studies suggest that dopaminergic tone influences resting state activity in multiple brain networks. Although dopamine receptors and transporters have been identified the posteromedial parietal cortices, which are linked to functional networks such as default mode network (DMN), relationship between receptor distribution these posterior regions resting-state connectivity has yet be explored. Here, we used a multi-modal neuroimaging strategy, combining magnetic resonance imaging...
The hypothesis of a serotonin (5-hydroxytryptamine [5-HT]) dysfunction in obsessive-compulsive disorder (OCD) stems largely from the clinical efficacy 5-HT reuptake inhibitors. Serotonergic abnormalities unmedicated symptomatic state, however, remain to be fully characterized.To investigate brain regional synthesis, as indexed by positron emission tomography and α-[(11)C]methyl-L-tryptophan trapping constant (K*), treatment-free adults meeting criteria for OCD.Between-group...
Head motion correction (MC) is an essential process in brain positron emission tomography (PET) imaging. We have used the Polaris Vicra, optical hardware-based tracking (HMT) device, for PET head MC. However, this requires attachment of a marker to subject's head. Markerless HMT (MLMT) methods are more convenient clinical translation than with external markers. In study, we validated United Imaging Healthcare (UMT) MLMT system using phantom and human point source studies, tested its...
Recent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict degree stimulus-induced activity same region. These used presentation discrete stimulus; change from closed eyes to open also represents a simple stimulus, however, and has been shown induce changes local brain functional connectivity between regions. We thus aimed investigate role system, specifically GABAA receptors, (EC) (EO) state order provide detail at receptor level complement previous...
Limited-angle data, such as data obtained from a dual-panel breast-PET scanner, result in substantial image blur directions coinciding with the missing cone of spectrum. On systems time-of-flight (TOF) capabilities, this is reduced given by TOF uncertainty, spectrum being correspondingly expanded into spectral cone. Modeling uncertainty reconstruction expected to deconvolve residual blurring. We have however observed that, tradeoff, de-blurring process also introduces ringing artifacts at...
This work assesses the one-step late maximum likelihood expectation maximization (OSL-MLEM) 4D PET reconstruction algorithm for direct estimation of parametric images from raw data when using simplified reference tissue model with basis function method (SRTM-BFM) kinetic analysis. To date, OSL-MLEM has been evaluated models based on two-tissue compartments an irreversible component. We extend evaluation this a reversible component, SRTM-BFM simulated 3D + time sets (with use [11C]raclopride...