A5072824936- Restless Legs Syndrome Research
- Vasculitis and related conditions
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Lysosomal Storage Disorders Research
- Dermatological and COVID-19 studies
- Renal Diseases and Glomerulopathies
- Streptococcal Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Healthcare Systems and Practices
- Sarcoidosis and Beryllium Toxicity Research
- Health, Medicine and Society
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Peripheral Neuropathies and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy and Medication Impact
- Autoimmune Neurological Disorders and Treatments
- Skin Diseases and Diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Complement system in diseases
- Myasthenia Gravis and Thymoma
Université de Montréal
1999-2025
Hôpital Joseph-Ducuing
2014-2023
Hôpital Émile-Roux
2023
Centre Hospitalier Universitaire de Caen
2023
Université de Caen Normandie
2023
Université Paris Cité
2022
Centre de Recherche Épidémiologie et Statistique
2022
Centre Hospitalier de l’Université de Montréal
2006-2022
Clinique Ambroise Paré
2022
Centre Hospitalier d'Arras
2021
<b><i>Objective: </i></b> To assess the frequency of periodic leg movements (PLM) in idiopathic REM sleep behavior disorder (RBD) and to analyze their polysomnographic characteristics associated autonomic cortical activation. <b><i>Background: PLM during (PLMS) wakefulness (PLMW) are typical features restless legs syndrome (RLS), but also frequently observed patients with RBD. <b><i>Methods: Forty RBD underwent one night recording PLMS frequency. features, PLMS-related cardiac activation...
Excessive and inappropriate production of pro-inflammatory cytokines plays a key role in Still's disease. Janus kinase inhibitor (JAKi) agents mainly block cytokine pathways, notably IL-6 IFN. The objective was to assess the efficacy safety JAKi difficult-to-treat systemic JIA or adult-onset disease (AOSD).This retrospective study based on national survey conducted departments rheumatology, paediatric rheumatology internal medicine French hospitals regarding AOSD patients who received...
We have estimated the time for last common ancestor of extant seed plants by using molecular clocks constructed from sequences chloroplastic gene coding large subunit ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) and nuclear small rRNA (Rrn18). Phylogenetic analyses nucleotide indicated that earliest divergence is likely represented a split between conifer-cycad angiosperm lineages. Relative-rate tests were used to assess homogeneity substitution rates among lineages, annual...
Abstract Recently, it was suggested that the intensity of restless legs syndrome (RLS) symptoms may be modulated by a circadian factor. The objective this study to evaluate, during 28‐hour modified constant routine, nycthemeral or variations in subjective leg discomfort and periodic movements (PLMs) parallel these changes with those vigilance, core body temperature, salivary melatonin. Seven patients primary RLS seven healthy subjects matched for sex age entered study. Although were more...
Restless legs syndrome (RLS) is a neurologic disorder characterized principally by leg paresthesia and motor restlessness. Several clinical reports indicated that many patients with RLS also have arm In the present study, incidence of restlessness was assessed questionnaire in 230 diagnosed idiopathic RLS. Arm reported 48.7% patients. Patients without were compared regard to polysomnographic parameters. No between-group differences found for age at onset RLS, duration illness, gender,...
Polysomnographic recordings and the Suggested Immobilization Test (SIT) are frequently used to support clinical diagnosis of restless legs syndrome (RLS). The present study evaluated discriminant power 5 different parameters: (1) index periodic leg movements during sleep (PLMS), (2) PLMS with an associated microarousal (PLMS-arousal), (3) PLM nocturnal wakefulness (PLMW), (4) SIT (5) mean subjective discomfort score (SIT MDS) in 100 patients idiopathic RLS 50 healthy control subjects. Both...
<b>Objective: </b> To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) order to establish topography of networks involved. <b>Methods: We performed blood flow evaluation using <sup>99m</sup>Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made SPM2. <b>Results: found increased pons putamen bilaterally right hippocampus. In addition, we observed a decreased...
Abstract Restless legs syndrome (RLS) is defined by an irresistible need to move associated with leg paresthesia. Two additional features are essential for diagnosis: (1) worsening of symptoms at rest temporary relief activity, and (2) during the evening and/or night. The suggested immobilization test (SIT) has been developed evaluate presence these criteria. This quantifies movements discomfort a 1‐hour period immobility prior bedtime. We used SIT effects on experienced 19 patients RLS...
Abstract Background Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature. Objective To determine and its predictors long-term follow-up bi-centric cohort SSc patients. Methods A retrospective observational study by systematically analyzing medical records patients diagnosed Toulouse University Hospital Ducuing Hospital. Standardized Mortality Ratio (SMR), at 1, 3, 5, 10, 15 years disease causes death were described. Predictors using Cox regression...
To assess the safety and efficacy of TNF-α antagonists tocilizumab in patients with Takayasu arteritis (TAK). A total 209 TAK [median age 29 years (interquartile range 7-62)], 186 (89%) females] were included. They received either [n = 132 (63%) 172 lines; infliximab (n 109), adalimumab 45), golimumab 8), certolizumab 6) etanercept 5)] or 77 (37%) 121 i.v. s.c. 95 26 cases, respectively]. complete response at 6 months was evidenced 101/152 (66%) on 75/107 (70%) tocilizumab. Age ≥30 [odds...
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) determine profile of polymyalgia rheumatica (PMR) giant cell arteritis (GCA) in COVID-19-vaccinated individuals. First, based on French database, we estimated RR PMR GCA cases individuals aged over 50 who developed their initial symptoms within one month receiving BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCoV-19, Ad26.COV2.S vaccines. then nationwide survey gather...
Self-directed manual wheelchair (MWC) mobility can facilitate participation in school, sports and community activities for pediatric MWC users (PMWUs), though many rely on others getting around. The Wheelchair Skills Training Program (WSTP) has demonstrated effectiveness improving adults with preliminary evidence pediatrics. However, rehabilitation professionals lack time to provide sufficient training. Expanding training opportunities within the community, such as schools, could be...
In order to examine the genetic substrate of dopamine hypothesis in restless legs syndrome, we analyzed eight genes coding for receptors and enzymes related dopaminergic transmission, using a population 92 patients with syndrome 182 controls matched ethnic background. No significant differences were found genotypic or allelic distributions between groups. Furthermore, no effect loci examined was observed stratification clinical parameters such as age at onset periodic leg movements during...
A high proportion of patients with restless legs syndrome (RLS) also complain arm paresthesia but the presence periodic movements (PAM) has never been documented in a sleep laboratory these patients. We investigated prevalence PAM during nocturnal and awakenings 22 RLS Fifteen had index >5 per hour wakefulness among them only 3 sleep. Twenty leg movement (PLM) 17 PLM In 42.8% cases, showed temporal relationship wakefulness. These results show that is frequent suggest basic neurological...