A5011142473- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Blood transfusion and management
- Airway Management and Intubation Techniques
- Neurosurgical Procedures and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiac and Coronary Surgery Techniques
- Pain Management and Opioid Use
- Spinal Hematomas and Complications
- Management of metastatic bone disease
- Cardiac Arrest and Resuscitation
- Medical History and Innovations
- Pain Management and Treatment
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Musculoskeletal pain and rehabilitation
- Kawasaki Disease and Coronary Complications
- Cannabis and Cannabinoid Research
- Renal function and acid-base balance
- History of Medicine Studies
- Cardiac Structural Anomalies and Repair
Université de Sherbrooke
2007-2023
Centre Hospitalier Universitaire de Sherbrooke
2008-2022
University of Toronto
2016
University Health Network
2016
Toronto General Hospital
2016
Sunnybrook Health Science Centre
2016
Health Sciences Centre
2016
McMaster University
2016
University of Manitoba
2016
St. Michael's Hospital
2016
The effect of a restrictive versus liberal red-cell transfusion strategy on clinical outcomes in patients undergoing cardiac surgery remains unclear.In this multicenter, open-label, noninferiority trial, we randomly assigned 5243 adults who had European System for Cardiac Operative Risk Evaluation (EuroSCORE) I 6 or more (on scale from 0 to 47, with higher scores indicating risk death after surgery) threshold (transfuse if hemoglobin level was <7.5 g per deciliter, starting induction...
Cardiac surgery is frequently complicated by coagulopathic bleeding that difficult to optimally manage using standard hemostatic testing. We hypothesized point-of-care testing within the context of an integrated transfusion algorithm would improve management coagulopathy in cardiac and thereby reduce blood transfusions.We conducted a pragmatic multicenter stepped-wedge cluster randomized controlled trial point-of-care-based consecutive patients undergoing with cardiopulmonary bypass at 12...
We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to liberal with respect the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure dialysis by hospital discharge 28 days after surgery, whichever came first. now report clinical outcomes 6 months surgery.
Cerebral oxygen desaturation during cardiac surgery has been associated with adverse perioperative outcomes. Before a large multicenter randomized controlled trial (RCT) on the impact of preventing desaturations outcomes, authors undertook prospective, parallel-arm, feasibility RCT to determine whether an intervention algorithm could prevent desaturations.Eight Canadian sites 201 patients between April 2012 and October 2013. The primary outcome was success rate reversing cerebral below 10%...
In Brief BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little known about the occurrence NMB in Canada. The RECITE (Residual Curarization its Incidence at Tracheal Extubation) study was prospective observational 8 hospitals Canada investigating incidence severity NMB. METHODS: Adult patients undergoing open or...
WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Research into major bleeding during cardiac surgery is challenging due to variability in how it scored. Two consensus-based clinical scores for bleeding: the Universal definition of perioperative and European Coronary Artery Bypass Graft (E-CABG) severity grade, were compared this substudy Transfusion Avoidance Cardiac Surgery (TACS) trial.As part TACS, 7,402 patients underwent at 12 hospitals from 2014 2015. We examined content validity...
We prospectively evaluated, in randomized order, 2 indirect methods of confirming the localization an epidural catheter for postoperative analgesia 218 surgical patients: stimulation test (EST) and pressure waveform analysis (EPWA). The space was localized by using a loss resistance technique. All catheters were inserted 5 cm into primed with mL 0.9% normal saline. There no differences between methods: positive predictive value specificity high (100% both groups), but sensitivity moderate...
Patients receiving oral or transdermal pharmacologic therapy with opioids and adjuvant may experience adequate pain control in 80%–90% of the cases, provided that this is administered by applying aggressive guidelines over time (1). Thus, other 10%–20% patients, some form invasive will be required (2). Neuraxial analgesia via an indwelling epidural intrathecal catheter provide to patients cancer who do not achieve systemic opioid (1,2). Moreover, these techniques are indicated when severe...
In Response: We would like to thank Dr. Tsui (1) for his interest in our work (2) and insightful comments. agree that the upper current limit used a positive epidural stimulation test should be increased at least 15 mA, with an appropriate elicited motor response. do not assertion "when catheter is situated properly within space, muscle twitches are typically much greater than 1 mA." study (2), of 167 patients test, 9 had unilateral response less or equal mA 19 1.5 mA. All these adequate...