A5079556874- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Ultrasound in Clinical Applications
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Cardiac Valve Diseases and Treatments
- Pregnancy and preeclampsia studies
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infective Endocarditis Diagnosis and Management
- Primary Care and Health Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ovarian function and disorders
- Pregnancy-related medical research
- Atrial Fibrillation Management and Outcomes
- Nutrition, Health and Food Behavior
- Intravenous Infusion Technology and Safety
- Gestational Diabetes Research and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
AstraZeneca (United Kingdom)
2023
McMaster University
2018-2021
Cardiff Metropolitan University
2018-2021
Population Health Research Institute
2020
Cardiff University
2014-2019
Toronto Public Health
2016-2019
Hamilton Health Sciences
2018-2019
Swansea University
2019
University of Cambridge
2016-2017
University of Toronto
2015-2017
We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to liberal with respect the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure dialysis by hospital discharge 28 days after surgery, whichever came first. now report clinical outcomes 6 months surgery.
Extracellular vesicles (EVs) are submicron released from many cell types, including adipocytes. EVs implicated in the pathogenesis of obesity-driven cardiovascular disease, although characteristics adipocyte-derived not well described. We sought to define before and after adipogenesis, hypothesising that adipogenesis would affect EV structure, molecular composition function. Using 3T3-L1 cells, were harvested at day 0 15 differentiation. preparations visualised by electron microscopy...
Objective: To assess the accuracy of Histoplasma capsulatum variety polysaccharide antigen testing for identification histoplasmosis relapse in patients with acquired immunodeficiency syndrome (AIDS). Design: A retrospective study using stored specimens. Setting: referral center and several private hospitals. Patients: Twenty episodes were evaluated 17 AIDS from November 1987 to August 1990. Controls included 30 who did not have a during maintenance therapy initially tested same week as...
Adipocyte-derived extracellular vesicles (EVs) may serve as novel endocrine mediators of adipose tissue and impact upon vascular health. However, it is unclear whether adipocyte-derived EVs are present in the human circulation. Therefore, purpose this study was to seek evidence for presence circulating plasma. Size-exclusion chromatography platelet-free plasma identified fractions 5 10 containing by a peak particle concentration, which corresponded with EV adipocyte proteins. Pooling...
Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. However, reduction is transient, indicating that the long-term cardiovascular benefits of apheresis may not solely be due to LDL removal. Microparticles (MPs) are submicron vesicles released from plasma membrane cells. MPs, particularly platelet-derived increasingly being linked pathogenesis many diseases. We aimed characterize effect on MP size, concentration, cellular origin, and fatty acid...
The role of extracellular vesicles (EV) in osteoarthritis has become the focus much research. These were isolated from several cell types found synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by fluid, it believed that EV might play a crucial homeostasis also could hold key information pathogenesis osteoarthritis. This thought to be due activation pro-inflammatory factors leading catabolic state degradation cartilage. In addition,...
STUDY QUESTIONAre circulating microparticles (MPs) altered in young women with polycystic ovary syndrome (PCOS)?
ABSTRACT Background and objectives Written verbal communication skills are important for all physicians. While taught assessed in medical school, students report limited instruction written skills. This study examined the impact of a curriculum delivered during 6-week clinical rotation Internal Medicine on objective assessment students’ Methods The consisted two educational programmes: student tutorial resident feedback workshop. was conducted from March 2012 to January 2013 at McMaster...
Abstract Introduction Despite multiple new drug advancements for patients with heart failure in recent years (specifically, sodium-glucose co-transporter-2 and sacubitril/valsartan), morbidity mortality remain high. AZD5462 is a selective RXFP1 agonist which mimics the pregnancy hormone relaxin its actions on systemic hemodynamics kidney function. Purpose To assess safety, tolerability, pharmacokinetics (PK) of first-in-human study following single ascending dose (SAD) (MAD) administration...
Abstract Rationale, aims, and objectives Access to timely ST‐elevation myocardial infarction (STEMI) care is facilitated by paramedics emergency medical services (EMS). However, a large proportion of STEMI patients do not access through EMS. This study sought identify patient‐reported factors for their decision use (or use) Methods Semi‐structured interviews were conducted with sample admitted tertiary centre between November 2011 January 2012. Participants grouped according mode...
Plasma fibronectin levels increased significantly over time in MRL/l mice with progressive autoimmune disease. At 100 and 120 days of age both male female exhibited higher (Fn) than the more resistant controls. Male at early points had Fn no greater controls due perhaps to later onset disease males. In contrast, mice, when compared MRL/n controls, from 40 age. The proteinuria these animals was also above first point taken (Day 40). a temporal study peaked reflected pattern survival curve,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Objective: High salt consumption is associated with increased blood pressure and vascular changes in humans. This association confounded by other lifestyle factors that could equally influence cardiovascular function. study examines effects of high diet on aortic function a controlled animal study. Design method: Sprague-Dawley rats were fed either (8% sodium chloride, n = 6) or normal chow (0.26% 5) from weaning. Body weight (BW), nose-to-rump length, tail-cuff systolic (SBP), water food...
INTRODUCTION: To determine whether patients with one abnormal value on the glucose tolerance test (GTT) have different outcomes compared to varying numbers of values. METHODS: We conducted a retrospective chart review women undergoing challenge (GCT) followed by GTT from July 2010-July 2015. Patients pre-gestational diabetes were excluded. Primary infant birth weight and mode delivery. Secondary included shoulder dystocia, NICU admission, development preeclampsia. Data was analyzed via...