A new manual search method was used to investigate the impact of naming on object individuation in 12-month-old infants. In Experiment 1, a two-word trial, an experimenter looked into box while infant watching and provided two labels (e.g., “Look, fep!” wug!”). On one-word instead repeated same label zav!”). After retrieved one from box, subsequent behavior recorded. Infants searched more persistently (i.e., for longer duration) after hearing than one, suggesting that led infants expect...

Autoradiographic experiments using iodinated vasopressin analog revealed the presence of specific vasopressin-binding sites in human adrenal cortex (zona glomerulosa and zona fasciculata). These receptors exhibited a good affinity for arginine (3.3 nM), with classical V1a pharmacology densities 65 135 fmol/mg protein-enriched membranes from fasciculata, respectively. Vasopressin present both fasciculata cell-enriched primary cultures were coupled to phospholipase C (ED50, 0.9 1.8 nM; maximal...

Self-directed manual wheelchair (MWC) mobility can facilitate participation in school, sports and community activities for pediatric MWC users (PMWUs), though many rely on others getting around. The Wheelchair Skills Training Program (WSTP) has demonstrated effectiveness improving adults with preliminary evidence pediatrics. However, rehabilitation professionals lack time to provide sufficient training. Expanding training opportunities within the community, such as schools, could be...

The present report details the role of Ca2+ in early events ACTH action human adrenal glomerulosa cells. Threshold stimulations both aldosterone and cAMP production were obtained with a concentration 10 pM ACTH, an ED50 0.1 nM, maximal stimulation (5.5-fold increase over control) at nM ACTH. also induced sustained intracellular calcium ([Ca2+]i) 1.6 +/- 0.1-fold control values. This does not involve mobilization from pools since no response was observed Ca2+-free medium or presence...

Context. Couple treatment for pathological gambling is an innovative strategy. There are some results supporting its potential effectiveness, but little known about the subjective experiences of participants. Objective. The aim this article to document gamblers and their partners participating in one two treatments, namely individual or couple. Method. In a study aiming evaluate efficacy Integrative Treatment Pathological Gambling (ICT-PG), couples who were entering specialized addiction...

People living with pathological gamblers (PGs) have to endure the negative consequences of their problem gambling. It is known that partners PGs will develop adaptation strategies cope gambling behaviour. However, research conducted on topic still in its early stages. The goal this study was draw up a portrait employed, context, means, and main goals, examine variation these over time viewpoints 2 members couple. Using 19 semi-structured interviews, we noted used some 30 aiming primarily at...

The aggregation of alpha-synuclein protein (αSyn) is a hallmark Parkinson's disease (PD). Considerable evidence suggests that PD involves an early αSyn in the enteric nervous system (ENS), spreading to brain. While it has previously been reported omega-3 polyunsaturated fatty acids (ω-3 PUFA) acts as neuroprotective agents brain murine models PD, their effect ENS remains undefined. Here, we studied dietary supplementation with docosahexaenoic acid (DHA, ω-3 PUFA), on ENS, particular focus...

Problem gambling can have profound consequences on a person's life, that range from financial, psychological to relational and affect, in particular, couple relationships. Despite these widely documented consequences, most therapies for problem favour an individual approach. Nonetheless, the field of addiction, several studies efficacy A few results preliminary carried out with gamblers would seem suggest approach might also be effective this field. Our team thus developed Integrative Couple...

Angiograms of 12 patients with typical Friedreich's ataxia were analyzed. The results corroborate previous reports and justify the conclusion that cardiomyopathy is hypertrophic type. In 10 cases, hypertrophy concentric, non obstructive. Less frequently (2 cases), this accompanied by diffuse hypokinesis depressed ejection fraction.

Assess the efficacy of integrative couple treatment for pathological gambling (ICT-PG) in comparison to provided an individual approach.Eighty couples were assigned randomly ICT-PG (n = 44, Mage 42.2, SD [13.4], n male gamblers 29) or 36, 39.9 [13.0], 31) with follow-ups at 4- and 10-months postadmission regarding severity gambling, couple's well-being. Linear mixed generalized estimating equation models repeated measures applied take into account dependency observations. Protocol was...

Gastrointestinal disorders in Parkinson's disease (PD) have been associated with neuronal alteration the plexus of gut. We previously demonstrated immunomodulatory effect female hormones to treat enteric neurodegeneration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model PD. This study made hypothesis obtaining similar neuroprotection as hormone treatments by affecting steroidogenesis two 5α-reductase inhibitors, finasteride and dutasteride. These drugs are approved benign...

Abstract Background Fatty acids are precursors in the synthesis of surfactant phospholipids. Recently, we showed expression apolipoprotein C-II (apoC-II), essential cofactor lipoprotein lipase (LPL), fetal mouse lung and found protein on day surge (gestation 17.5) secretory granule-like structures distal epithelium. In present study, will answer following questions: Does apoC-II localization change according to stage development, thus need surfactant? Are LPL molecules translocated luminal...

Gambling's impact on a couple's relationship is an essential element in the gambling disorder (GD). Gamblers tend to lie their partner conceal extent of problems and debts, which can lead serious relational transgression for couple. One promising avenue couple treatment focusing forgiveness processes. The objective this study was determine whether Integrative Couple Treatment Pathological (ICT-PG) with emphasis processes helped couples enhance these A Single-Case Research Design (SCRD) used...

The 3Rs stand for Replacement of animals in experiments, Reduction the number experimental animals, and Refinement experiments to minimize animal pain stress. We propose address use mice as models developmental research. This study focuses on maternal percentage weight increase at gestational day 8 (%WIGD8) diagnose pregnancy early BALB/c mice. documented sensitivity, specificity, false positive negative rates probability associated with %WIGD8. predictive model allows significant reduction...