A5031818647- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Fatty Acid Research and Health
- Hormonal Regulation and Hypertension
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Scoliosis diagnosis and treatment
- Photoreceptor and optogenetics research
- Hormonal and reproductive studies
- Reflective Practices in Education
- Neuroscience and Neural Engineering
- Neurological diseases and metabolism
- Cardiovascular Effects of Exercise
- Attention Deficit Hyperactivity Disorder
- RNA regulation and disease
- Restless Legs Syndrome Research
- Empathy and Medical Education
- Cell Image Analysis Techniques
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Craniofacial Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
Université Laval
2014-2024
Centre hospitalier universitaire de Québec
2018-2023
Institut National d'Optique
2023
NutriNeuro
2023
Centre hospitalier de l'Université Laval
2020
Centre Hospitalier Universitaire Sainte-Justine
2020
Université de Sherbrooke
2020
Université de Montréal
2020
Center for Neurosciences
2018
Hôpital du Saint-Sacrement
2014
Diabetic kidney disease (DKD) is the main cause of chronic (CKD) and progresses faster in males than females. We identify sex-based differences metabolism blood metabolome male female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy displayed increased mitochondrial respiration, oxidative stress, apoptosis, greater injury when exposed to high glucose compared PTECs Male showed glutamine fluxes TCA cycle, whereas pyruvate content. The PTEC...
Background:Accumulating evidence supports a role for the immune system in pathogenesis of Parkinson's disease. Importantly, recent preclinical studies are now suggesting specific contribution inflammation to α-synuclein-induced pathology seen this condition.
The mutation and overexpression of the alpha-synuclein protein (αSyn), described as synucleinopathy, is associated with Parkinson’s disease (PD)-like pathologies. A higher prevalence PD documented for men versus women, suggesting female hormones’ implication in slowing progression. nigrostriatal dopamine (DA) neurons rodent males are more vulnerable to toxins than those females. effect biological sex on synucleinopathy remains poorly was investigated using mice knocked out murine αSyn...
Huntington's disease (HD) is a hereditary disorder that typically manifests in adulthood with combination of motor, cognitive and psychiatric problems. The pathology caused by mutation the huntingtin gene which results production an abnormal protein, mutant (mHtt). This protein ubiquitously expressed known to confer toxicity multiple cell types. We have recently reported HD brains are also characterised vascular abnormalities, include changes blood vessel density/diameter as well increased...
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, exact role pathophysiology these remains unclear. This gap knowledge is due lack experimental models that allow for spatiotemporal control aggregation, investigation early dynamic events inclusion formation. Here, we report on development light-inducible (LIPA) system enables α-synuclein (α-syn) into insoluble deposits called...
Parkinson's disease (PD) is characterized by neurodegeneration and neuroinflammation. PD prevalence incidence are higher in men than women modulation of gonadal hormones could have an impact on the course. This was investigated male female gonadectomized (GDX) SHAM operated (SHAM) mice. Dutasteride (DUT), a 5α-reductase inhibitor, administered to these mice for 10 days modulate their sex hormones. On fifth day DUT treatment, received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model...
The aggregation of alpha-synuclein protein (αSyn) is a hallmark Parkinson's disease (PD). Considerable evidence suggests that PD involves an early αSyn in the enteric nervous system (ENS), spreading to brain. While it has previously been reported omega-3 polyunsaturated fatty acids (ω-3 PUFA) acts as neuroprotective agents brain murine models PD, their effect ENS remains undefined. Here, we studied dietary supplementation with docosahexaenoic acid (DHA, ω-3 PUFA), on ENS, particular focus...
Gastrointestinal disorders in Parkinson's disease (PD) have been associated with neuronal alteration the plexus of gut. We previously demonstrated immunomodulatory effect female hormones to treat enteric neurodegeneration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model PD. This study made hypothesis obtaining similar neuroprotection as hormone treatments by affecting steroidogenesis two 5α-reductase inhibitors, finasteride and dutasteride. These drugs are approved benign...
The evolution and treatment of lung alterations related to congenital spine chest wall deformities (CWD) are poorly understood. Most animal models CWD created postnatally were not evaluated for respiratory function. goal our study was evaluate the effects a induced in utero on growth function an ovine model.
ABSTRACT Male sex is a risk factor for progression of diabetic kidney disease, but the reasons this predilection are unclear. Here, we demonstrate that cell and hormones alter metabolic phenotype human proximal tubular epithelial cells (PTECs). PTECs displayed increased glycolysis, mitochondrial respiration, oxidative stress, apoptosis, high glucose-induced injury, compared to female PTECs. This was enhanced by dihydrotestosterone (DHT) linked utilization glucose glutamine. Studies in vivo...
α-synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs) is the paramount pathological hallmark of Parkinson's disease and related α-synucleinopathies. However, how these aggregates affect neuronal homeostasis leading neurodegeneration remains elusive. This gap in knowledge mainly due lack proper cellular animal models undertake such investigations. We have addressed this by developing a light-inducible protein (LIPA) system that allows for real-time...
α-Synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs), is the paramount pathological hallmark of Parkinson's disease (PD) and related α-synucleinopathies. However, mechanism by which these aggregates contribute neurodegeneration remains unclear. This gap in knowledge due lack experimental models that allow for spatiotemporal control α-syn investigation early dynamic events associated with inclusion formation. Here, we report on development a...