A5026839838- T-cell and Retrovirus Studies
- Herpesvirus Infections and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Biotin and Related Studies
- RNA regulation and disease
- Toxoplasma gondii Research Studies
- Cellular transport and secretion
- Animal Disease Management and Epidemiology
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- bioluminescence and chemiluminescence research
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Vector-Borne Animal Diseases
- Insect behavior and control techniques
- Zebrafish Biomedical Research Applications
- Insect Pest Control Strategies
- Molecular Communication and Nanonetworks
- Insect Utilization and Effects
Icahn School of Medicine at Mount Sinai
2024
Albert Einstein College of Medicine
2022-2024
Université Laval
2016-2020
Institut Universitaire en Santé Mentale de Québec
2016
Universidade Federal do Rio Grande do Sul
2009
Universidade Federal de Santa Catarina
2009
Significance Degeneration of midbrain dopamine neurons is the main pathological hallmark Parkinson’s disease. Identifying transcriptional programs that maintain these in adult brain will help us understand their specific vulnerability. Here, we show survival dopaminergic requires ongoing action LIM-homeodomain transcription factors Lmx1a and Lmx1b. We discovered an Lmx1a/b-dependent pathway maintaining mitochondrial functions neurons. Accordingly, ablation Lmx1a/b results impaired...
Neurexins are highly spliced transmembrane cell adhesion molecules that bind an array of partners via their extracellular domains. However, much less is known about the signaling pathways downstream neurexin’s largely invariant intracellular domain (ICD). Caenorhabditis elegans contains a single neurexin gene we have previously shown required for presynaptic assembly and stabilization. To gain insight into mediating functions, employed proximity ligation method, endogenously tagging with...
Mesodiencephalic dopamine neurons play central roles in the regulation of a wide range brain functions, including voluntary movement and behavioral processes. These functions are served by distinct subtypes mesodiencephalic located substantia nigra pars compacta ventral tegmental area, which form nigrostriatal, mesolimbic, mesocortical pathways. Until now, mechanisms involved dopaminergic circuit formation remained largely unknown. Here, we show that Lmx1a, Lmx1b, Otx2 transcription factors...
The role of synaptic activity during early formation neural circuits is a topic some debate; genetic ablation neurotransmitter release by deletion the Munc18-1 gene provides an excellent model to answer question whether such required for circuit formation. Previous analysis −/− mouse mutants documented their grossly normal nervous system, but its molecular differentiation has not been assessed. in mice also results widespread neurodegeneration that remains poorly characterized. In this...
This study investigates the Drosophilidae species associated to fruiting bodies of fungi in forested and anthropized environments Atlantic Rain Forest Biome, south southeastern Brazil. We collected samples imagoes flying over emerging from five families, six collection sites. obtained 18 samples, which emerged 910 drosophilids 31 genera Drosophila Fallen, 1823, Hirtodrosophila Duda, 1923, Leucophenga Mik, 1886, Mycodrosophila Oldenberg, 1914, Scaptomyza Hardy, 1849, Zaprionus Coquillett,...
Abstract Background The molecular etiology of tau‐derived neurodegeneration remains poorly understood, reflected in the low success rate clinical trials. Hence, aquiring a better understanding basis tauopathies is critical need. Objective To develop versatile and reproducible system to study tau aggregation with high spatiotemporal control through optogenetics that will aid investigating differences kinetics, burden isoforms, mutations be suitable for high‐throughput analysis...
α-synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs) is the paramount pathological hallmark of Parkinson's disease and related α-synucleinopathies. However, how these aggregates affect neuronal homeostasis leading neurodegeneration remains elusive. This gap in knowledge mainly due lack proper cellular animal models undertake such investigations. We have addressed this by developing a light-inducible protein (LIPA) system that allows for real-time...
Abstract Neurexins are highly-spliced transmembrane cell adhesion molecules that bind an array of partners via their extracellular domains. However, much less is known about the signaling pathways downstream neurexin’s largely-invariant intracellular domain. C. elegans contains a single neurexin gene we have previously shown required for presynaptic assembly and stabilization. To gain insight into mediating functions, employed proximity ligation method, endogenously tagging domain with...
Abstract Mesodiencephalic dopamine (mDA) neurons play a wide range of brain functions. Distinct subtypes mDA regulate these functions but the molecular mechanisms that drive circuit formation are largely unknown. Here we show autophagy, main recycling cellular pathway, is present in growth cones developing and its level changes dynamically response to guidance cues. To characterize role autophagy axon growth/guidance, knocked-out (KO) essential genes ( Atg12, Atg5) mice neurons. Autophagy...