A5020926527- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Parkinson's Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
- Attention Deficit Hyperactivity Disorder
- Photochromic and Fluorescence Chemistry
- Circadian rhythm and melatonin
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Zebrafish Biomedical Research Applications
- Advanced Fluorescence Microscopy Techniques
Université Laval
2019-2023
Inserm
2016
Neurocentre Magendie
2016
Institut Universitaire en Santé Mentale de Québec
2015
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, exact role pathophysiology these remains unclear. This gap knowledge is due lack experimental models that allow for spatiotemporal control aggregation, investigation early dynamic events inclusion formation. Here, we report on development light-inducible (LIPA) system enables α-synuclein (α-syn) into insoluble deposits called...
Abstract Maternal stress is associated with an altered mother-infant relationship that endangers offspring development, leading to emotional/behavioral problems. However, little research has investigated the stress-induced alterations of maternal brain could underlie such a disruption bonding. Olfactory cues play extensive role in coordination interactions, suggesting motherhood may be enhanced olfactory performances, and this effect abolished by stress. To test hypothesis, we analyzed...
Abstract The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. olfactory bulb is particularly prone constant reshaping because ongoing neurogenesis. It remains unclear whether the complexity distinct odor-induced learning paradigms and sensory stimulation induces different forms structural plasticity. In present study, we automatically reconstructed spines 3D from confocal images performed unsupervised clustering based on morphometric...
Abstract The adult mouse olfactory bulb is continuously supplied with new neurons that mostly differentiate into granule cells (GCs). Different subtypes of adult-born GCs have been identified, but their maturational profiles and roles in bulbar network functioning odor behavior remain elusive. It also not known whether the same subpopulations born during early postnatal life (early-born) or adulthood (adult-born) differ morpho-functional properties. Here, we show calretinin-expressing (CR +...
During adulthood, the activation of adult neural stem cells (NSCs) has been mostly studied ex vivo in post-mortem tissues or anesthetized animals. This protocol presents an approach that allows for long-term and minimally invasive investigation NSC physiology freely behaving By combining specific labeling mini-endoscopic microscopy, live imaging division Ca2+ activity can be performed continuously 2–3 days even up to several months. For complete details on use execution this protocol, please...
ABSTRACT Neural stem cells (NSCs) are maintained in specific regions of the postnatal brain and contribute to its structural functional plasticity. However, long-term renewal potential NSCs their mode division remain elusive. The use advanced vivo live imaging approaches may expand our knowledge NSC physiology provide new information for cell replacement therapies. In this Review, we discuss methods used study dynamics recent live-imaging results with respect intracellular pathways that...
α-synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs) is the paramount pathological hallmark of Parkinson's disease and related α-synucleinopathies. However, how these aggregates affect neuronal homeostasis leading neurodegeneration remains elusive. This gap in knowledge mainly due lack proper cellular animal models undertake such investigations. We have addressed this by developing a light-inducible protein (LIPA) system that allows for real-time...
α-Synuclein (α-syn) aggregation into insoluble deposits, referred to as Lewy bodies (LBs), is the paramount pathological hallmark of Parkinson's disease (PD) and related α-synucleinopathies. However, mechanism by which these aggregates contribute neurodegeneration remains unclear. This gap in knowledge due lack experimental models that allow for spatiotemporal control α-syn investigation early dynamic events associated with inclusion formation. Here, we report on development a...
Abstract During development and in adulthood the morpho-functional properties of neural networks constantly adapt response to environmental stimuli learned experiences. One processes that allows neuronal be reshaped is synaptic plasticity, which induced sensory experience learning. Synaptic plasticity for formation/elimination connections as well strengthening pre-existing ones. The olfactory system particularly prone constant reshaping rewiring throughout lifespan an animal, mainly because...