A5103214612- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Blood groups and transfusion
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Infectious Diseases and Mycology
- Chemotherapy-related skin toxicity
- Hormonal Regulation and Hypertension
- Renal and related cancers
- Lymphadenopathy Diagnosis and Analysis
- Colorectal Cancer Treatments and Studies
- Endometrial and Cervical Cancer Treatments
- Mycobacterium research and diagnosis
- Xenotransplantation and immune response
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Colorectal and Anal Carcinomas
- Birth, Development, and Health
- Intraperitoneal and Appendiceal Malignancies
University Health Network
2023-2024
Toronto General Hospital
2024
University of Toronto
2024
Toronto General Hospital Research Institute
2024
Royal Marsden NHS Foundation Trust
2002-2003
Diabetic kidney disease (DKD) is the main cause of chronic (CKD) and progresses faster in males than females. We identify sex-based differences metabolism blood metabolome male female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy displayed increased mitochondrial respiration, oxidative stress, apoptosis, greater injury when exposed to high glucose compared PTECs Male showed glutamine fluxes TCA cycle, whereas pyruvate content. The PTEC...
Lymphadenopathy is common, affecting patients of all ages. The current referral pattern for investigating with lymphadenopathy varies widely no universally practised pathway. Our institution set up a lymph node diagnostic clinic (LNDC) accepting direct referrals from primary care physicians. Details clinical presentation and investigations were recorded prospectively. Between December 1996 July 2001, 550 referred (M: 203; F:347). median age was 40 years (range 14-90). time between initial...
Standard chemotherapy for advanced epithelial ovarian cancer is a combination of platinum-paclitaxel. One strategy to improve the outcome patients add other agents standard therapy. Doxil active in relapsed disease and has response rate 25% platinum-resistant disease. A dose finding study doxil-carboplatin-paclitaxel was therefore undertaken women receiving first-line Thirty-one with or mixed Mullerian tumours ovary were enrolled. The doses carboplatin, paclitaxel doxil as follows:...
This study used a prospectively managed clinical database in order to identify 1470 patients with gastrointestinal cancers receiving protracted venous infusion (PVI) fluorouracil (5FU). It aimed determine the time course of toxicity due PVI 5FU and analyse factors predicting toxicity. The initial development stomatitis occurred more rapidly than diarrhoea or palmar plantar erythema (PPE). percentage National Cancer Institute Common Toxicity Criteria (CTC) grade 2 worse PPE peaked at 9%...
Introduction Kidney transplantation is the optimal treatment for end-stage kidney disease; however, premature allograft loss remains a serious issue. While many high-throughput omics studies have analyzed patient biospecimens, integration of these datasets challenging, which represents considerable barrier to advancing our understanding mechanisms loss. Methods To facilitate integration, we created curated database containing all open-access from human transplant studies, termed NephroDIP...
Manion, Kieran; Allen, Maya A.; Freixas, Sergi Clotet; John, Rohan; Konvalinka, Ana Author Information