A5058431339- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Smoking Behavior and Cessation
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging Techniques and Applications
- Resilience and Mental Health
- Memory and Neural Mechanisms
- Posttraumatic Stress Disorder Research
- Advanced MRI Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Glioma Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Epilepsy research and treatment
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Bipolar Disorder and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- bioluminescence and chemiluminescence research
- Neural dynamics and brain function
Yale University
2016-2025
National Center for Post Traumatic Stress Disorder
2019-2025
VA Connecticut Healthcare System
2014-2024
United States Department of Veterans Affairs
2017-2024
National Center for PTSD
2014-2024
Yale Cancer Center
2014-2020
New York Psychoanalytic Society and Institute
2019
New York State Psychiatric Institute
2019
Connecticut Mental Health Center
2011-2017
Columbia University
2014-2016
Synaptic loss and deficits in functional connectivity are hypothesized to contribute symptoms associated with major depressive disorder (MDD) post-traumatic stress (PTSD). The synaptic vesicle glycoprotein 2A (SV2A) can be used index the number of nerve terminals, an indirect estimate density. Here, we positron emission tomography (PET) SV2A radioligand [11C]UCB-J examine density n = 26 unmedicated individuals MDD, PTSD, or comorbid MDD/PTSD. severity was inversely correlated density, high...
Available levels of nicotinic acetylcholine receptors containing the beta(2) subunit (beta(2)*-nAChR) are higher in recently abstinent tobacco smokers compared with participants who never smoked. Variations beta(2)*-nAChR availability during course abstinence may be related to urge smoke, extent nicotine withdrawal, and successful abstinence.To examine changes acute prolonged from smoking determine how were clinical features smoking.Tobacco participated up 4 iodide 123-labeled 5-iodo-A-85380...
Significance Posttraumatic stress disorder (PTSD) is a highly prevalent and disabling disorder, but there are currently no targeted medications for its treatment. Glutamate dysfunction thought to be involved in the pathophysiology of PTSD, metabotropic glutamate receptor 5 (mGluR5) may represent treatment target. We show alterations mGluR5 availability vivo mGluR5- glucocorticoid-related gene expression postmortem tissue providing insight into molecular mechanisms underlying this disorder....
Chronic stress accounts for billions of dollars economic loss annually in the United States alone, and is recognized as a major source disability mortality worldwide. Robust evidence suggests that chronic plays significant role onset severe impairing psychiatric conditions, including depressive disorder, bipolar posttraumatic disorder. Application molecular imaging techniques such positron emission tomography single photon computed recent years has begun to provide insight into mechanisms by...
Background: Modulation of nicotinic acetylcholine receptors (nAChRs), specifically those containing the β2 subunit, may be effective in treating patients with major depressive disorder. Using [123I]5-I-A-85380 single photon emission computed tomography (SPECT), authors studied availability β2-subunit-containing nAChRs (β2*-nAChRs) depressed patients. To understand its molecular basis, also β2*-nAChR binding postmortem brain samples from subjects. Method: The participants were 23...
The purpose of this study was to investigate the effects ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) radioligand [11C]PBR28. [11C]PBR28 data from 140 volunteers (72 males 68 females; N = 78 with HAB 62 MAB genotype; age range 19–80 years; BMI 17.6–36.9) were acquired High Resolution Research Tomograph at three centres: Karolinska Institutet (N 53), Turku PET centre 62) Yale University Center...
Abstract Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation individuals with PTSD. [ 11 C]PBR28 Positron Emission Tomography imaging the 18-kDa translocator protein (TSPO), a microglial biomarker, was conducted 23 PTSD and 26 healthy individuals—with or without trauma exposure. Prefrontal-limbic TSPO availability group negatively associated symptom severity significantly lower than controls. Higher...
Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise loss of synapses PD and other disorders. Here, we provide new clinical insights a cross-sectional, high-resolution positron emission tomography (PET) study 30 individuals age- sex-matched healthy controls (HC) with radiotracer [ 11 C]UCB-J, which binds to synaptic vesicle...
Background Neuroimaging studies have revealed that disturbances in network organization of key brain regions may underlie cognitive and emotional dysfunction posttraumatic stress disorder (PTSD). Examining both structure function the same population further our understanding alterations PTSD. Methods We used tensor-based morphometry intrinsic connectivity distribution to identify altered volume functional unmedicated individuals with PTSD ( n = 21) healthy comparison participants 18). These...
Converging evidence suggests that major depressive disorder (MDD) affects multiple large-scale brain networks. Analyses of the correlation or covariance regional structure and function applied to structural functional MRI data may provide insights into systems-level organization structure-to-function correlations in MDD. This study tensor-based morphometry intrinsic connectivity distribution identify regions altered volume from unmedicated individuals with MDD (n=17) healthy comparison...
Introduction: While the detrimental impact of Russian-Ukrainian War on mental health Ukrainian population has been well-documented, less attention given to workers (MHWs) providing support services amid war.
 Purpose: To examine levels domain-specific well-being in MHWs; identify and quantify relative importance factors associated with well-being; interactions risk protective relation each domain.
 Methodology: A convenience sample 178 MHWs completed a survey that assessed their...