A5053471306- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Malaria Research and Control
- Mosquito-borne diseases and control
- BRCA gene mutations in cancer
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Global Maternal and Child Health
- Childhood Cancer Survivors' Quality of Life
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Antibiotic Resistance in Bacteria
- Treatment of Major Depression
- Child Nutrition and Water Access
- Functional Brain Connectivity Studies
- Travel-related health issues
- Infectious Encephalopathies and Encephalitis
- Fatty Acid Research and Health
- Pharmacological Receptor Mechanisms and Effects
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Visual perception and processing mechanisms
- Heart Failure Treatment and Management
- Urban Planning and Governance
- Nutrition and Health in Aging
Medical College of Wisconsin
2021-2023
Mayo Clinic
2023
University of North Carolina at Greensboro
2021
Johnson & Johnson (United States)
2021
Yale University
2009-2020
Clinton Health Access Initiative
2015-2019
Children's Hospital of Wisconsin
2019
Gates Foundation
2017
Duke University Hospital
2016
Duke Medical Center
2016
A novel water quality intervention that consists of point-of-use disinfection, safe storage and community education was field tested in Bolivia. total 127 households two periurban communities were randomized into control groups, surveyed the distributed. Monthly testing weekly diarrhoea surveillance conducted. Over a 5-month period, had 44% fewer episodes than ( P =0·002). Infants <1 year old =0·05) children 5–14 years =0·01) significantly less children. Campylobacter commonly isolated...
Background Patients with major depressive disorder (MDD) show deficits in processing of facial emotions that persist beyond recovery and cessation treatment. Abnormalities neural areas supporting attentional control emotion remitted depressed (rMDD) patients suggests there may be enduring, trait-like abnormalities key circuits at the interface cognition emotion, but this issue has not been studied systematically. Method Nineteen euthymic, medication-free rMDD (mean age 33.6 years; mean...
Background: Modulation of nicotinic acetylcholine receptors (nAChRs), specifically those containing the β2 subunit, may be effective in treating patients with major depressive disorder. Using [123I]5-I-A-85380 single photon emission computed tomography (SPECT), authors studied availability β2-subunit-containing nAChRs (β2*-nAChRs) depressed patients. To understand its molecular basis, also β2*-nAChR binding postmortem brain samples from subjects. Method: The participants were 23...
Major depressive disorder (MDD) is a mood that not traditionally considered to affect the visual system. However, recent findings have reported decreased cortical levels of inhibitory neurotransmitter GABA in occipital cortex. To explore possible functional consequences MDD on processing, we applied psychophysical motion processing task which healthy young adults typically exhibit impaired perceptual discrimination large high-contrast stimuli. It has been suggested this phenomenon, spatial...
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan Lorberg B, Zhao H, Newton SS, Mane Epperson CN, Sinha R, Blumberg Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disord 2010: 12: 813–824. © 2010 The Authors.Journal compilation John Wiley & Sons A/S. Objective: To identify specific genetic pathways showing altered depressed subjects with disorder (BPD). Methods:...
Lithium is considered by many as the gold standard medication in management of bipolar disorder (BD). However, clinical response to lithium heterogeneous, and molecular basis for this difference unknown. In present study, we sought determine how peripheral blood gene expression profiles patients with (BD) changed over time following intitiation treatment lithium, whether differences those were related response.Illumina Sentrix Beadchip (Human-6v2) microarrays containing > 48,000 transcript...
Background Despite the benefits of malaria diagnosis, most presumed episodes are never tested. A primary reason is absence diagnostic tests in retail establishments, where many patients seek care. Malaria rapid (RDTs) drug shops hold promise for guiding appropriate treatment. However, providers generally lack awareness RDTs and training to administer them. Further, unsubsidized may be unaffordable unattractive retailers. This paper reports results from an intervention study testing...
Article AbstractObjective: To study the efficacy of adjunctive levetiracetam therapy compared with placebo in treatment subjects depression bipolar disorder.Method: This double-blind, placebo-controlled clinical trial randomly assigned outpatients disorder type I and II who were experiencing a major depressive episode (Structured Clinical Interview for DSM-IV Axis Disorders-Clinician Version criteria) to either or (up 2,500 mg/d flexibly dosed) 6 weeks. The recruited from October 2005 June...
Abstract Background Tanzania has seen a reduction in the fraction of fevers caused by malaria, likely due part to scale-up control measures. While national guidelines require parasite-based diagnosis prior treatment, it is estimated that more than half suspected malaria treatment-seeking initiates private retail sector, where rapid diagnostic test (RDT) or microscopy illegal. This pilot study investigated whether introduction RDTs into Accredited Drug Dispensing Outlets (ADDOs) under...
Febrile infection–related epilepsy syndrome (FIRES) is characterized by explosive onset refractory status epilepticus (RSE) in healthy individuals that to antiseizure medication (ASM), continuous anesthetic infusions (CIs), and immunomodulators. Recently, a case series of patients receiving intrathecal dexamethasone (IT-DEX) was reported with improved RSE control.
• Although breast carcinoma is the most frequently occurring cancer in American women and has been subject of extensive epidemiologic investigation, little attention devoted to use risk-factor information its control. Six our 52 breast-cancer-prone families have at least one woman who manifested age 30 years or earlier. One such family had two with before 30, ten others affected by 50. Transmission this lesion was consistent autosomal-dominant mode inheritance. Ages onset indicated a notably...
Objective To evaluate the impact -on diagnosis and treatment of malaria -of introducing rapid diagnostic tests to drug shops in eastern Uganda.Methods Overall, 2193 households 79 study villages with at least one licensed shop were enrolled monitored for 12 months.After 3 months monitoring, vendors 67 randomly selected intervention offered training use -if trained -offered access such a subsidized price.The remaining served as controls.A difference-in-differences regression model was used...
The κ-opioid receptors (KORs) are implicated in several neuropsychiatric diseases and addictive disorders. PET with radioligands provides a means to image the KOR vivo investigate its function health disease. purpose of this study was develop selective antagonist <sup>11</sup>C-LY2459989 as radioligand characterize imaging performance nonhuman primates. <b>Methods:</b> LY2459989 synthesized assayed for vitro binding opioid receptors. Ex studies rodents were conducted assess potential tracer...
Integrating seasonal malaria chemoprevention (SMC), recommended by the WHO since 2012 to prevent infection, with nutrition interventions may improve health outcomes and operational efficiencies. This study assessed effects of co-packaging on distribution coverage, nutrition, clinical in northern Nigeria. From August November 2014, community volunteers delivered sulfadoxine-pyrimethamine amodiaquine (SP-AQ) door-to-door each month approximately 7,000 children aged 6–24 months seven wards...
Abstract Aims Icosapent ethyl lowers triglycerides and significantly reduces major adverse cardiovascular events (MACE), though treatment effects may vary between individuals. This study aimed to determine the relative absolute of icosapent on MACE according baseline disease (CVD) risk in patients with atherosclerotic (ASCVD). Methods Results Participants from Reduction Cardiovascular Events Ethyl—Intervention Trial (REDUCE-IT) ASCVD were included (n = 5785). The primary outcome was 3-point...
In Uganda, as in most other malaria-endemic countries, presumptive treatment for malaria based on symptoms without a diagnostic blood test is still very common. While testing public sector facilities increasing, many people Uganda who suspect visit private outlets to purchase medications. Increasing the availability and uptake of rapid tests (RDTs) could help increase but raises questions about patient demand valuation that are less critical introduction. preparation behaviour change...
The diagnosis of cancer in a child, adolescent, or young adult is an emotionally overwhelming time. To improve the quality education and support provided to patients caregivers with new diagnosis, we executed improvement initiative (a) define key milestones for delivery essential during first 2 months following (b) role accountability within multidisciplinary team content execution tasks. develop milestones, identified educational from review literature, determined sequence through...
Serotonergic neurotransmission plays a key role in the pathophysiology and treatment of various neuropsychiatric diseases. The purpose this study was to investigate changes serotonergic after acute tryptophan depletion (ATD) using positron emission tomography (PET) with [11 C]P943, 5-HT1B receptor radioligand previously shown be sensitive 5-HT. Five healthy subjects were scanned on high resolution PET scanner twice same day, before approximately 5 hours ingesting capsules containing an amino...
Durlobactam (formerly ETX2514) is a diazabicyclooctane β-lactamase inhibitor that inhibits class A, C, and D β-lactamases. Sulbactam combined with durlobactam has in vitro vivo activity against Acinetobacter baumannii including carbapenem- colistin-resistant isolates being developed for treating serious infections due to A. baumannii. The effect of single supratherapeutic dose on the heart rate corrected QT interval (QTc) was evaluated healthy subjects placebo- active-controlled,...
Subjects searched for a chromatic target among coloured background items. With low target-background similarity, response latencies remained uniformly short whether the was present or not and items were chromatically homogeneous not. Latencies increased with increases in similarity longest heterogeneous backgrounds, which effects of trial also became manifest. We employed Treisman's model visual search to account these findings. In particular, we suggest that forced shift from preattentive...