A5071040525- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Graphene research and applications
- Carbon and Quantum Dots Applications
- Carbon Nanotubes in Composites
- Anesthesia and Neurotoxicity Research
- Nanoparticle-Based Drug Delivery
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- Radioactive element chemistry and processing
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Heavy Metal Exposure and Toxicity
- Radioactivity and Radon Measurements
- Polysaccharides and Plant Cell Walls
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Carcinogens and Genotoxicity Assessment
- Supramolecular Self-Assembly in Materials
- Air Quality and Health Impacts
- Polysaccharides Composition and Applications
- Hydrogels: synthesis, properties, applications
- Nanotechnology research and applications
- Enzyme Production and Characterization
- Bone Tissue Engineering Materials
University of Manchester
2016-2025
Environmental Research Institute
2025
Henry Royce Institute
2015-2025
Manchester Academic Health Science Centre
2016-2024
Beijing Graphene Institute
2014-2020
Faculty (United Kingdom)
2017
University College London
2012-2015
Inserm
2007-2013
University of London
2011-2012
Laboratoire de physique des Solides
2008-2009
Many consider carbon nanomaterials the poster children of nanotechnology, attracting immense scientific interest from many disciplines and offering tremendous potential in a diverse range applications due to their extraordinary properties. Graphene is youngest family nanomaterials. Its isolation, description, mass fabrication has followed that fullerenes nanotubes. Graphene's development its adoption by industries will increase unintended or intentional human exposure, creating need...
Stroke is the second cause of death worldwide with ischemic stroke accounting for 80% all insults. Caspase-3 activation contributes to brain tissue loss and downstream biochemical events that lead programmed cell after traumatic injury. Alleviation symptoms following neuronal injury can be potentially achieved by either genetic disruption or pharmacological inhibition caspases. Here, we studied whether silencing using carbon nanotube-mediated in vivo RNA interference (RNAi) could offer a...
Graphene oxide nanomaterials are being developed for wide-ranging applications but associated with potential safety concerns human health. We conducted a double-blind randomized controlled study to determine how the inhalation of graphene nanosheets affects acute pulmonary and cardiovascular function. Small ultrasmall at concentration 200 μg m
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets graphene in 2004 due to specific and versatile properties these materials. However, increasing production use 2D necessitate a thorough evaluation potential impact on human health environment. Furthermore, harmonized test protocols are needed with which assess safety The Graphene Flagship project (2013-2023), funded by European Commission, addressed identification possible...
Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with emergence of several other atomically thin displaying multifunctional properties. The safety assessment often something an afterthought, but case graphene, initial characterization material was soon followed by potential impact on living systems. Flagship project addressed health environmental aspects graphene materials, providing instructive lesson interdisciplinarity - from to biology....
The aim of this study was to evaluate adverse effects multiwalled carbon nanotubes (MWCNT), produced for industrial purposes, on the human epithelial cell line A549. MWCNT were dispersed in dipalmitoyl lecithin (DPL), a component pulmonary surfactant, and dispersion DPL compared those two other media: ethanol (EtOH) phosphate-buffered saline (PBS). Effects also asbestos fibers (chrysotile crocidolite) black (CB) nanoparticles, not only A549 cells but mesothelial (MeT5A line), used as an...
Abstract Graphene‐based materials (GBM) have outstanding properties that proven highly beneficial in several proof‐of‐concept investigations on their biomedical potential. They can be used as suspensions of nanosheets for nanomedicine purposes well components macroscale products medical devices or tissue engineering/regenerative medicine products. However, the clinical translation these preclinical concepts is hampered by incomplete understanding biocompatibility GBM general, and limited...
Carbon nanotubes (CNTs) are increasingly being utilized in neurological applications as components of implants, electrodes or delivery vehicles. Any application that involves implantation injection CNTs into the CNS needs to address distribution and fate material following interaction residence within neuronal tissue. Here we report a preliminary study investigating structural integrity amino-functionalized stereotactic administration brain cortex.The investigated had previously shown...
The interest in graphene and its translation into commercial products has been expanding at a high pace. Based on previously described pulmonary safety concerns for carbon nanomaterials, there is great need to define parameters guiding interactions between graphene-based materials the system. aim of present study was determine importance two critical parameters: lateral dimensions material coating with proteins relation each other their impact. Endotoxin-free distinct dimensions, s-GO...
carbon nanotubes (CNT) can have adverse effects on health. Therefore, minimizing the risk associated with CNT exposure is of crucial importance. The aim this work was to evaluate if coating multi-walled (MWCNT) polymers could modify their toxicity, thus representing a useful strategy decrease health CNT. We used industrially-produced MWCNT uncoated (NT1) or coated (50/50 wt%) acid-based (NT2) polystyrene-based (NT3) polymer, and exposed murine macrophages (RAW 264.7 cell line) Balb/c mice by...
Surface tunability and their ability to translocate plasma membranes make chemically functionalized carbon nanotubes (f-CNTs) promising intracellular delivery systems for therapeutic or diagnostic purposes in the central nervous system (CNS). The present study aimed determine biological impact of different types multiwalled CNTs (MWNTs) on primary neuronal glial cell populations isolated from fetal rat frontal cortex (FCO) striatum (ST). Neurons both brain regions were generally not affected...
Graphene-based materials (GBMs) have ignited a revolution in material science and technology, with electronic, optical mechanical properties that are of relevant interest for wide range applications. To support the development these enabling technologies, global research effort has been invested to assess their hazard biocompatibility. Different production methods however generated diverse collection GBMs different physicochemical properties, leading variety biological outcomes still not...
Given the increasing use of carbon nanotubes (CNT) in composite materials and their possible expansion to new areas such as nanomedicine which will both lead higher human exposure, a better understanding potential cause adverse effects on health is needed. Like other nanomaterials, biological reactivity toxicity CNT were shown depend various physicochemical characteristics, length has been suggested play critical role. We therefore designed comprehensive study that aimed at comparing murine...
Carbon nanomaterials, including 2D graphene-based materials, have shown promising applicability to drug delivery, tissue engineering, diagnostics, and various other biomedical areas. However, exploit the benefits of these materials in some areas mentioned, it is necessary understand their possible toxicological implications long-term fate vivo. We previously demonstrated that following intravenous administration, graphene oxide (GO) nanosheets were largely excreted via kidneys; however, a...
Safety assessment of graphene-based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors society. In particular, the link between specific material properties and biological effects needs to be further elucidated. Here, lateral dimensions GO sheets in acute chronic pulmonary responses after single intranasal instillation mice are compared. Micrometer-sized induces stronger inflammation than nanometer-sized GO, despite reduced translocation lungs....
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years terms of safety assessment. However, limited information is available concerning the hazard potential GRM-containing products such as graphene-reinforced composites. In present study, we conducted a comprehensive investigation biological effects particles released through an abrasion process from reduced graphene oxide (rGO)-reinforced composites polyamide 6...
Triggerable drug delivery from polymeric implants offers the possibility to generate remote-controlled release profiles that may overcome deficiencies of conventional administration routes (intravenous injections and oral administration) including toxicity due overdose systemic administration. An electro-responsive system was engineered deliver molecules in a pulsatile manner, controlled by on/off application electric voltage. Pristine multi-walled carbon nanotubes (pMWNTs) were incorporated...
The development of efficient contrast agents for cell labelling coupled with powerful medical imaging techniques is great interest monitoring trafficking potential clinical applications such as organ repair and regenerative medicine. In this paper, functionalised multi-walled carbon nanotubes (MWNTs) were engineered in T1-weighted MRI applications. These sophisticated constructs covalently the gadolinium (Gd) chelating agent, diethylene triamine pentaacetic acid (DTPA), enabling tight...
Long-term (up to 90 day) monitoring of internalised carbon nanotubes in a primary microglia cell culture model allowed detection their intracellular degradation.
With the rapid developments in medical applications of carbon nanomaterials such as nanohorns (CNHs), nanotubes, and graphene based nanomaterials, understanding long-term fate, health impact, excretion, degradation these materials has become crucial. Herein, vitro biodegradation CNHs was determined using a non-cellular enzymatic oxidation method two types macrophage cell lines. Approximately 60% degraded within 24 h phosphate buffer solution containing myeloperoxidase. Furthermore,...
Graphene-based materials (GBMs) have promising applications in various sectors, including pulmonary nanomedicine. Nevertheless, the influence of GBM physicochemical characteristics on their fate and impact lung has not been thoroughly addressed. To fill this gap, biological response, distribution, bio-persistence four different GBMs mouse lungs up to 28 days after single oropharyngeal aspiration are investigated. None GBMs, varying size (large versus small) carbon oxygen ratio as well...