A5102997229- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Diabetes and associated disorders
- Liver Diseases and Immunity
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Celiac Disease Research and Management
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Immunodeficiency and Autoimmune Disorders
- Multiple Sclerosis Research Studies
- Cytokine Signaling Pathways and Interactions
- Mobile Health and mHealth Applications
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Parvovirus B19 Infection Studies
- Inflammatory Bowel Disease
Hospital for Sick Children
2019-2025
University of Toronto
1994-2025
SickKids Foundation
2019-2025
Emory University
2023-2024
American College of Rheumatology
2023-2024
University of North Carolina at Chapel Hill
2023-2024
AID Atlanta
2023-2024
Durham VA Medical Center
2023-2024
Convergence
2024
Rheumatology Consultants
2023
Depression and anxiety adversely affects outcomes in systemic lupus erythematosus (SLE) healthcare utilization is high for pediatric SLE. We aimed to characterize the prevalence of depression SLE, their association with utilization. conducted a cross-sectional analysis SLE mixed connective tissue disease (MCTD) subjects healthy controls aged 8 years above. used Patient Health Questionnaire 9 (PHQ-9) Screen Childhood Anxiety Related Disorders (SCARED) identify depression, suicidal ideation...
There are no population-based estimates of the incidence or risk factors for acute cardiac manifestations in children with systemic lupus erythematosus (SLE) to guide screening and diagnostic imaging practices. We estimated prevalence child-onset SLE compared adult-onset identified associated diagnoses.We (5-17 years) adults (18-64 incident (≥3 International Classification Diseases, Ninth Revision, Clinical Modification (ICD-9 CM) code 710.0, > 30 days apart) using Clinformatics® DataMart...
Objective To compare major depression risk among young adults with juvenile‐onset and adult‐onset systemic lupus erythematosus ( SLE ), to determine demographic health‐related predictors of depression. Methods Young ages 18–45 years (n = 546) in the Lupus Outcomes Study completed annual telephone surveys from 2002–2015, including assessment using Center for Epidemiologic Studies Depression Scale CES ‐D), self‐report measures sociodemographics health characteristics. Juvenile‐onset was...
Performing adequately powered clinical trials in pediatric diseases, such as SLE, is challenging. Improved recruitment strategies are needed for identifying patients.Electronic health record algorithms were developed and tested to identify children with SLE both without lupus nephritis. We used single-center electronic data develop computable phenotypes composed of diagnosis, medication, procedure, utilization codes. These evaluated iteratively against a manually assembled database patients...
Objective Estimate the prevalence of allergic, neurodevelopmental, and autoimmune diagnoses in children born to anti‐Ro antibody positive mothers. Methods A cohort study mothers followed Neonatal Lupus Erythematosus clinic (NLE) at SickKids Hospital. Participants ≥ 1 year age were invited complete a health status questionnaire. Prevalence disease compared between from NLE non‐NLE population‐based CHILD Cohort Study. Descriptive statistics used for demographics, manifestations outcomes....
Pediatric rheumatologic diseases (PRDs) are characterized by high rates of anxiety and depression known to impact health-related outcomes. We present guidance statements assess manage mental health concerns for youth with PRDs in pediatric rheumatology practice. Development the was initiated 2019 concluded November 2023. It included: 1) Formation a taskforce (including rheumatologists, behavioral providers, patients, parents), led two licensed psychologists board-certified 2) Iterative...
Objective This study aimed to identify themes contributing resilience in childhood‐onset systemic lupus erythematosus (cSLE), distinguish between profiles resilience, and examine how they relate underlying patient characteristics. Methods We conducted a mixed‐methods of twenty‐one cSLE patients aged 11‐19 years at Canadian tertiary care centre from October 2022‐July 2024. purposively sampled belonging ethnically culturally diverse backgrounds complete semi‐structured interviews....
Objective. To estimate the national prevalence and racial/ethnic differences in psychiatric diagnoses pharmacologic treatment a US Medicaid beneficiary population of youth with systemic lupus erythematosus (SLE). Methods. We included aged 10 to 18 years diagnosis SLE (defined as ≥ 3 outpatient visit claims an International Classification Diseases, 9th ed. code 710.0, each > 30 days apart) Analytic Extract database from 2006 2007. This contains all inpatient 49 states District Columbia....
Objective We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). Methods conducted 32 semi-structured interviews 16 outpatient SLE/MCTD, age 11 22 years, and their parents. qualitatively defined key features families distinguished profiles adapting well vs poorly SLE/MCTD. then related these illness, patient-level attributes outcomes. Results Experiences SLE/MCTD grouped into five themes: managing...
Objective. To identify targets for improving mental healthcare of adolescents with systemic lupus erythematosus (SLE) by assessing current practices and perceived barriers health intervention pediatric rheumatology clinicians. Methods. Members the Childhood Arthritis Rheumatology Research Alliance (CARRA) completed a Web-based survey practices, beliefs, barriers. We examined associations between provider characteristics frequency to screening treatment using multivariable linear regression....
Youth with systemic lupus erythematosus (SLE) experience high rates of psychiatric comorbidities, which may affect medication adherence. We undertook this study to examine the association between disorders and hydroxychloroquine adherence determine whether treatment modifies association.We identified incident users among youth SLE (ages 10-24 years) using de-identified US commercial insurance claims in Optum Clinformatics Data Mart (2000-2016). Adherence was estimated possession ratios...
Our objective was to characterize adolescent health and psychosocial issues in patients with childhood-onset systemic lupus erythematosus (cSLE) evaluate demographic disease characteristics associated health.
Depressive and anxiety symptoms are common in childhood-onset systemic lupus erythematosus (cSLE), yet their etiology course remain unclear. We investigated the frequency of depressive longitudinally youth with cSLE, associated socio-demographic disease factors.
To identify behavioral health provider perspectives on gaps in mental care for youth with rheumatologic conditions.Social workers (n = 34) and psychologists 8) at pediatric rheumatology centers the Childhood Arthritis Rheumatology Research Alliance (CARRA) completed an online survey assessing current practices needs of conditions. Responses were compared to a published CARRA rheumatologists 119). Thematic analysis 20 semi-structured interviews providers was performed.One-third 100) had no...
Childhood-onset systemic erythematosus lupus (cSLE) is characterized by more severe disease, widespread organ involvement and higher mortality compared to adult-onset SLE. However, cSLE largely underfunded carry out necessary research advance the field. Few commonly used SLE medications have been studied in children, important knowledge gaps exist concerning epidemiology, genetics, pathophysiology optimal treatments for cSLE. In order assess highest priority areas, Lupus Foundation of...
Abstract Background Loss of the normal nocturnal decline in blood pressure (BP), known as non-dipping, is a potential measure cardiovascular risk identified by ambulatory monitoring (ABPM). We sought to determine whether non-dipping useful marker abnormal vascular function and subclinical atherosclerosis pediatric-onset systemic lupus erythematosus (pSLE). Methods Twenty subjects 9–19 years age with pSLE underwent ABPM, peripheral endothelial testing, carotid-femoral pulse wave...
Mental health disorders are common in youth with rheumatological disease yet optimal intervention strategies understudied this population. We examined patient and parent perspectives on mental for disease.
Objective. In the setting of recent healthcare advances and emphasis on reduced spending, we aimed to characterize US trends in inpatient use mortality for pediatric systemic lupus erythematosus (SLE). Methods. We performed a retrospective, serial, cross-sectional analysis national Kids’ Inpatient Database (for 2000, 2003, 2006, 2009). identified patients with SLE aged 2 21 years using an International Classification Diseases , 9th revision (ICD-9) code 710.0 listed as discharge diagnosis....
Untreated mental health problems may result in poor outcomes for youth with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). We investigated perceptions, barriers facilitators healthcare of these youth. conducted 32 semi-structured interviews 16 outpatient SLE/MCTD, ages 11–22 years, their parents. used purposive sampling to deliberately obtain the experiences screened during a previous study depression anxiety Patient Health Questionnaire 9 Screen Childhood...