A5071070019- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Diseases and Immunity
- Acute Lymphoblastic Leukemia research
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Iron Metabolism and Disorders
- Eosinophilic Esophagitis
- Acne and Rosacea Treatments and Effects
- COVID-19 and healthcare impacts
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Celiac Disease Research and Management
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Pharmaceutical studies and practices
- Vaccine Coverage and Hesitancy
- Health Systems, Economic Evaluations, Quality of Life
- Mycobacterium research and diagnosis
- Erythropoietin and Anemia Treatment
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
Philadelphia VA Medical Center
2014-2024
University of Pennsylvania
2015-2024
Karachi Medical and Dental College
2014-2024
Brunel University of London
2022-2024
University of Chester
2023
Amity University
2023
Research Network (United States)
2022
Mount Vernon Cancer Centre
2022
Nanoplus (Germany)
2022
Qassim University
2022
Little is known about the risk factors for, and of, developing post-COVID-19 conditions (PCCs) among children.To estimate proportion of SARS-CoV-2-positive children with PCCs 90 days after a positive test result, to compare this SARS-CoV-2-negative children, assess associated PCCs.This prospective cohort study, conducted in 36 emergency departments (EDs) 8 countries between March 7, 2020, January 20, 2021, included 1884 who completed 90-day follow-up; 1686 these were frequency matched by...
Background and Aims Corticosteroids are effective for the short-term treatment of inflammatory bowel disease (IBD). Long-term use, however, is associated with significant adverse effects. To define the: (1) frequency duration corticosteroid (2) escalation to corticosteroid-sparing therapy, (3) rate complications related (4) appropriate bone density measurements (dual energy X-ray absorptiometry [DEXA] scans), (5) factors DEXA scans. Methods Retrospective review Veterans Health Administration...
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly expanded; however, clinical trials excluded patients taking immunosuppressive medications such as those with inflammatory bowel disease (IBD). Therefore, we explored real-world effectiveness of 2019 (COVID-19) vaccination on subsequent infection in IBD diverse exposure to medications.This was a retrospective cohort study the Veterans Health Administration diagnosed before December 18, 2020, start...
The efficacy and safety of vedolizumab, a gut-selective α4β7 integrin antibody, were demonstrated in the GEMINI 1 2 clinical trials adults aged 18–80 years. We investigated vedolizumab patients stratified by age from trials. Safety efficacy, including response, remission, corticosteroid-free at week 6 and/or 52 determined post hoc <35, 35 to <55, ≥55 At baseline, 353, 412, 130 ulcerative colitis (UC) 582, 443, 90 Crohn's disease (CD) ≥55. Of these patients, 56 ≥65 years (UC: 33, CD: 23)....
Objective Our aim was to explore the risk of infection with all classes inflammatory bowel disease (IBD) medications and impact these on course in a nationwide cohort patients IBD. Design This retrospective national study IBD Veterans Affairs Healthcare System. We categorised medication use immediately prior COVID-19 pandemic used survival analysis methods associations SARS-CoV-2 infection, as well combined secondary outcome hospitalisation or COVID-19-related mortality. Results The...
There are limited data on the risk of non-melanoma skin cancer (NMSC) and melanoma (MSC) among thiopurine-treated patients with ulcerative colitis (UC). Our aim was to investigate while on, by cumulative years, after stopping thiopurine therapy.Nationwide were obtained from Veterans Affairs (VA) health-care system during 2001-2011. We performed a retrospective cohort study evaluating UC. Cox regression used association between thiopurines use time NMSC adjusting for demographics, ultraviolet...
The recent outbreak of the novel coronavirus disease 2019 (COVID-19) has become a pandemic and is threatening global health.1Wang C. et al.Lancet. 2020; 395: 470-473Abstract Full Text PDF PubMed Scopus (5092) Google Scholar highest number COVID-19 confirmed cases were reported in United States, with 1.47 million 89,272 deaths as May 19, 2020.2World Health Organization. Available at:...
To evaluate the role of albumin at time ulcerative colitis (UC) diagnosis in predicting clinical course disease.
The clinic course of SARS-CoV-2 among patients with inflammatory bowel disease (IBD) has been extensively studied. However, there is a paucity data on whether IBD have an increased risk developing compared without IBD.We conducted nationwide retrospective cohort study in the US Veterans' Affairs healthcare system from January 1, 2020, to June 30, 2020. We matched each patient 2 age, sex, race, location, and comorbidities. outcome interest was development SARS-CoV-2.Among 38,378 67,433 IBD,...
Abstract Background Inflammatory bowel disease (IBD) treatment in the elderly is challenging part because of increased risk infections. The aim our study was to determine absolute and relative infections among IBD patient population identify factors affecting overall population. Methods A retrospective patients with initiating corticosteroids, immunomodulators (IM), or biologic therapy (January 2010–December 2014) conducted using Truven Market Scan database. IM exposure were assessed a...
Summary Background Adherence is a major factor in determining disease activity ulcerative colitis ( UC ). There are limited data on long‐term nationwide adherence levels among patients with . Aim To evaluate the to oral mesalazine (mesalamine) Veterans Affairs VA ) healthcare system, determine impact of non‐adherence risk flares, and different pharmacy data‐based indicators. Methods Nationwide were obtained from for period 2001–2011. who started maintenance during inclusion included. Level...
Management of elderly inflammatory bowel disease (IBD) patients (≥ 65 years age) is complicated due to many factors, including a higher risk cancer, which may impact therapeutic decisions.The aim this study was determine the cancer among IBD compared with younger patients. Additionally, absolute malignancy and factors contributing it were evaluated, patterns assessed.This retrospective cohort extracted data from Truven Health Analytics MarketScan® database. Among adult who free before...
Summary Background There are limited data regarding clinical outcomes in ulcerative colitis ( UC ) patients who require early corticosteroids CS use. Aim To evaluate the rate of utilisation (within 30 days diagnosis) as a predictive marker for long‐term outcomes, colectomy and dependency, population‐based cohort incident cases. Methods Nationwide were obtained from Veterans Affairs VA health care system period 2001–2011. Incident cases identified. A retrospective design time‐to‐event...
There are limited data about the long-term follow-up of patients with ulcerative colitis (UC) maintained on high versus low doses mesalamine. We evaluated best average daily dose that would keep disease in remission. Nationwide were obtained from Veterans Affairs health care system for period 2001 to 2011. Those who started mesalamine maintenance during this included. Average and level adherence assessed between first dispense date flare defined as filling 40 mg/day or more oral prednisone...
Abstract Background The elderly inflammatory bowel disease (IBD) population has historically been under-represented in clinical trials, and data on the efficacy of biologic medications IBD patients are generally lacking. Our study aims to evaluate vedolizumab (VDZ) among compare it with younger a nationwide population-based cohort patients. Methods We conducted retrospective within US national Veterans Affairs Healthcare System (VAHS). Patients were stratified into 2 groups based age at time...
The standard approach for the surgical management of colorectal cancer (CRC) in setting ulcerative colitis (UC) involves total proctocolectomy (TPC). However, some patients also undergo a partial resection (PR). This may be an attractive option older with high risk surgery. aim this study was to compare metachronous after PR or TPC CRC UC.This retrospective cohort conducted through Nationwide Veterans Affairs Healthcare System (VA). Patients who had UC and underwent were followed from time...